Molecular taphonomy of membrane constituents the search for the most primitive membranes

1996 ◽  
Vol 26 (3-5) ◽  
pp. 276-277
Author(s):  
Guy Ourisson ◽  
Yoichi Nakatani
Keyword(s):  
Primitive Membranes

Networks of passive competition between multiple self-ordering proto-replicators and the effect of primitive membranes

Biosystems ◽  
2010 ◽  
Vol 101 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Richard M.P. Sayer
Keyword(s):  
Primitive Membranes

Overview on primitive membranes

1996 ◽  
Vol 26 (3-5) ◽  
pp. 272-273 ◽  
Author(s):  
Pier Luigi Luisi
Keyword(s):  
Primitive Membranes

scholarly journals Discovery in space of ethanolamine, the simplest phospholipid head group

2021 ◽  
Vol 118 (22) ◽  
pp. e2101314118
Author(s):  
Víctor M. Rivilla ◽  
Izaskun Jiménez-Serra ◽  
Jesús Martín-Pintado ◽  
Carlos Briones ◽  
Lucas F. Rodríguez-Almeida ◽  
...  
Keyword(s):  
Amino Acids ◽  
Interstellar Medium ◽  
Column Density ◽  
Cell Membranes ◽  
Genetic Material ◽  
Early Earth ◽  
Head Group ◽  
Interstellar Space ◽  
The One ◽  
Primitive Membranes

Cell membranes are a key element of life because they keep the genetic material and metabolic machinery together. All present cell membranes are made of phospholipids, yet the nature of the first membranes and the origin of phospholipids are still under debate. We report here the presence of ethanolamine in space, NH2CH2CH2OH, which forms the hydrophilic head of the simplest and second-most-abundant phospholipid in membranes. The molecular column density of ethanolamine in interstellar space is N = (1.51± 0.07)× 1013 cm−2, implying a molecular abundance with respect to H2 of (0.9−1.4) × 10−10. Previous studies reported its presence in meteoritic material, but they suggested that it is synthesized in the meteorite itself by decomposition of amino acids. However, we find that the proportion of the molecule with respect to water in the interstellar medium is similar to the one found in the meteorite (10−6). These results indicate that ethanolamine forms efficiently in space and, if delivered onto early Earth, could have contributed to the assembling and early evolution of primitive membranes.

Sodium di-polyprenyl phosphates form “primitive” membranes

1992 ◽  
Vol 33 (36) ◽  
pp. 5249-5252 ◽  
Author(s):  
Niklas Plobeck ◽  
Stéphane Eifler ◽  
Alain Brisson ◽  
Yoichi Nakatani ◽  
Guy Ourisson
Keyword(s):  
Polyprenyl Phosphates ◽  
Primitive Membranes

Single-Chain Polyprenyl Phosphates Form“Primitive” Membranes

1996 ◽  
Vol 35 (2) ◽  
pp. 177-180 ◽  
Author(s):  
Gianluca Pozzi ◽  
Véronique Birault ◽  
Birgit Werner ◽  
Olivier Dannenmuller ◽  
Yoichi Nakatani ◽  
...  
Keyword(s):  
Single Chain ◽  
Polyprenyl Phosphates ◽  
Primitive Membranes

Chemistry and Physics of Primitive Membranes

2005 ◽  
pp. 1-27 ◽  
Author(s):  
David W. Deamer ◽  
Jason P. Dworkin
Keyword(s):  
Primitive Membranes

Reinforcing effect of bi- and tri-cyclopolyprenols on ‘primitive’ membranes made of polyprenyl phosphates

Tetrahedron ◽  
2007 ◽  
Vol 63 (16) ◽  
pp. 3395-3407 ◽  
Author(s):  
Nigel Ribeiro ◽  
Stéphane Streiff ◽  
Denis Heissler ◽  
Mourad Elhabiri ◽  
Anne Marie Albrecht-Gary ◽  
...  
Keyword(s):  
Reinforcing Effect ◽  
Polyprenyl Phosphates ◽  
Primitive Membranes

scholarly journals Why do proteins aggregate? “Intrinsically insoluble proteins” and “dark mediators” revealed by studies on “insoluble proteins” solubilized in pure water

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 94 ◽  
Author(s):  
Jianxing Song
Keyword(s):  
Membrane Proteins ◽  
Membrane Protein ◽  
High Selectivity ◽  
Pure Water ◽  
Integral Membrane Protein ◽  
Integral Membrane Proteins ◽  
Common Mechanism ◽  
Interacting Proteins ◽  
Primitive Membranes

In 2008, I reviewed and proposed a model for our discovery in 2005 that unrefoldable and insoluble proteins could in fact be solubilized in unsalted water. Since then, this discovery has offered us and other groups a powerful tool to characterize insoluble proteins, and we have further addressed several fundamental and disease-relevant issues associated with this discovery. Here I review these results, which are conceptualized into several novel scenarios. 1) Unlike 'misfolded proteins', which still retain the capacity to fold into well-defined structures but are misled to 'off-pathway' aggregation, unrefoldable and insoluble proteins completely lack this ability and will unavoidably aggregate in vivo with ~150 mM ions, thus designated as 'intrinsically insoluble proteins (IIPs)' here. IIPs may largely account for the 'wastefully synthesized' DRiPs identified in human cells. 2) The fact that IIPs including membrane proteins are all soluble in unsalted water, but get aggregated upon being exposed to ions, logically suggests that ions existing in the background play a central role in mediating protein aggregation, thus acting as 'dark mediators'. Our study with 14 salts confirms that IIPs lack the capacity to fold into any well-defined structures. We uncover that salts modulate protein dynamics and anions bind proteins with high selectivity and affinity, which is surprisingly masked by pre-existing ions. Accordingly, I modified my previous model. 3) Insoluble proteins interact with lipids to different degrees. Remarkably, an ALS-causing P56S mutation transforms the β-sandwich MSP domain into a helical integral membrane protein. Consequently, the number of membrane-interacting proteins might be much larger than currently recognized. To attack biological membranes may represent a common mechanism by which aggregated proteins initiate human diseases. 4) Our discovery also implies a solution to the 'chicken-and-egg paradox' for the origin of primitive membranes embedded with integral membrane proteins, if proteins originally emerged in unsalted prebiotic media.

Search for the Most Primitive Membranes: Some Remaining Problems

2012 ◽  
Vol 42 (5) ◽  
pp. 497-501 ◽  
Author(s):  
Yoichi Nakatani ◽  
Nigel Ribeiro ◽  
Stéphane Streiff ◽  
Laurent Désaubry ◽  
Guy Ourisson
Keyword(s):  
Primitive Membranes

scholarly journals Search for the Most ‘primitive’ Membranes and Their Reinforcers: A Review of the Polyprenyl Phosphates Theory

2014 ◽  
Vol 44 (3) ◽  
pp. 197-208 ◽  
Author(s):  
Yoichi Nakatani ◽  
Nigel Ribeiro ◽  
Stéphane Streiff ◽  
Mari Gotoh ◽  
Gianluca Pozzi ◽  
...  
Keyword(s):  
Polyprenyl Phosphates ◽  
Primitive Membranes
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