The seeded growth of calcium phosphates. The kinetics of growth of dicalcium phosphate dihydrate on hydroxyapatite

1976 ◽  
Vol 21 (12) ◽  
pp. 171-182 ◽  
Author(s):  
J. P. Barone ◽  
G. H. Nancollas ◽  
M. Tomson
Keyword(s):  
Calcium Phosphates ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Seeded Growth ◽  
Phosphate Dihydrate ◽  
Kinetics Of

Seeded Growth of Calcium Phosphates: Effect of Different Calcium Phosphate Seed Material

1976 ◽  
Vol 55 (4) ◽  
pp. 617-624 ◽  
Author(s):  
G.H. Nancollas ◽  
J.S. Wefel
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Calcium Phosphates ◽  
Octacalcium Phosphate ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Seeded Growth ◽  
Seed Crystals ◽  
Phosphate Dihydrate ◽  
Supersaturated Solutions

The growth of calcium phosphates on seed materials, dicalcium PhosPhate dihydrate (DCPD), tricalcium phosphate (TCP), octacalcium phosphate (OCP), and hydroxyapatite (HAP) in stable supersaturated solutions has been studied under conditions of pH and concentration for which the predominant phases are 1, DCPD, and II, HAP. All seed crystals are good nucleators for DCPD in system I, but, aside from HAP itself, only OCP will readily induce growth under condition II.

scholarly journals Controlled synthesis of dicalcium phosphate dihydrate (DCPD) from metastable solutions: insights into pathogenic calcification

2021 ◽  
Vol 32 (12) ◽  
Author(s):  
A. D. Rafeek ◽  
G. Choi ◽  
L. A. Evans
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Calcium Phosphate ◽  
Electrostatic Interactions ◽  
The Body ◽  
Dicalcium Phosphate ◽  
Urinary Stones ◽  
Dicalcium Phosphate Dihydrate ◽  
Seeded Growth ◽  
Phosphate Dihydrate

AbstractCalcium phosphate (CaP) compounds may occur in the body as abnormal pathogenic phases in addition to their normal occurrence as bones and teeth. Dicalcium phosphate dihydrate (DCPD; CaPO4·2H2O), along with other significant CaP phases, have been observed in pathogenic calcifications such as dental calculi, kidney stones and urinary stones. While other studies have shown that polar amino acids can inhibit the growth of CaPs, these studies have mainly focused on hydroxyapatite (HAp; Ca10(PO4)6(OH)2) formation from highly supersaturated solutions, while their effects on DCPD nucleation and growth from metastable solutions have been less thoroughly explored. By further elucidating the mechanisms of DCPD formation and the influence of amino acids on those mechanisms, insights may be gained into ways that amino acids could be used in treatment and prevention of unwanted calcifications. The current study involved seeded growth of DCPD from metastable solutions at constant pH in the presence of neutral, acidic and phosphorylated amino acid side chains. As a comparison, solutions were also seeded with calcium pyrophosphate (CPP; Ca2P2O7), a known calcium phosphate inhibitor. The results show that polar amino acids inhibit DCPD growth; this likely occurs due to electrostatic interactions between amino acid side groups and charged DCPD surfaces. Phosphoserine had the greatest inhibitory ability of the amino acids tested, with an effect equal to that of CPP. Clustering of DCPD crystals giving rise to a “chrysanthemum-like” morphology was noted with glutamic acid. This study concludes that molecules containing an increased number of polar side groups will enhance the inhibition of DCPD seeded growth from metastable solutions.

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