Treatment of severe persistent pulmonary hypertension of newborn with magnesium sulfate

1993 ◽  
Vol 60 (4) ◽  
pp. 597-600
Author(s):  
Lalitha Krishnan ◽  
N. A. D. Souza ◽  
M. Baliga
Keyword(s):  
Pulmonary Hypertension ◽  
Magnesium Sulfate ◽  
Persistent Pulmonary Hypertension

scholarly journals Efficacy of a combination of sildenafil and magnesium sulfate in the treatment of persistent pulmonary hypertension of the newborn, and its influence on hemodynamics

2021 ◽  
Vol 20 (10) ◽  
pp. 2163-2169
Author(s):  
Shuping Huang ◽  
Tao Zhong
Keyword(s):  
Pulmonary Hypertension ◽  
Magnesium Sulfate ◽  
Vascular Resistance ◽  
Post Treatment ◽  
Persistent Pulmonary Hypertension ◽  
Inflammatory Factors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Respiratory Parameters ◽  
Combined Use ◽  
Hospitalization Period

Purpose: To investigate the efficacy of the combined use of sildenafil and magnesium sulfate in the treatment of persistent pulmonary hypertension of the newborn (PPHN), and its influence on hemodynamics.Methods: A total of 174 children with persistent pulmonary hypertension who were treated in Ganzhou People’s Hospital, Ganzhou, China were selected and randomly assigned to joint group (JG) and control group (CG), with 87 patients in each group. The CG group received magnesium sulfate, while the JG group received sildenafil plus magnesium sulphate. The respiratory parameters of the children were analyzed using blood gas analyzer, while their hemodynamic indices were evaluated using color Doppler echocardiography. The levels of cytokines and inflammatory factors were determined by enzyme-linked immunosorbent assay (ELISA).Results: Time taken for symptom disappearance, oxygen therapy, and hospitalization period were shorter in JG than in CG (p < 0.05). Post-treatment, the respiratory parameters (PaO2, PaCO2, and SaO2) in both groups s improved, with lower levels of PaO2 and PaCO2, and a higher level of SaO2 in JG (p < 0.05). Following treatment, the levels of systemic vascular resistance (SVR), posterior pulmonary vascular resistance (PVR) and pulmonary artery pressure (PA) in JG were significantly reduced, relative to CG (p < 0.05). Similarly, the expression of endothelin -1 (ET-1), brain natriureticpeptide (BNP), and angiotensin 1 (ANG-1) improved, with lower levels of ET-1 and BNP, and a higher level of ANG-1 in JG (p < 0.05). There was post-treatment reduction as well in IL-6 and TNF-α, with lower levels in JG (p < 0.05). Patients in JG showed higher total treatment effectiveness and a lowerincidence of adverse reactions than those in CG (p < 0.05).Conclusion: The combined use of sildenafil and magnesium sulfate enhances the management of PPHN, ameliorates respiratory parameters, hemodynamics, and levels of cytokines and inflammatory factors. These findings provide evidence-based medical references for a new treatment strategy for PPHN.

The Role of Magnesium Sulfate in the Treatment of Persistent Pulmonary Hypertension in the Neonate : Our Experience in King Hussein Medical Centre (KHMC)

2020 ◽  
Vol 27 (2) ◽  
pp. 21-26
Author(s):  
Ayash , Fadi Farhan ◽  
Saleh , Alaeddin Ali ◽  
Alyassen , Abdalrazzaq Ahmad ◽  
Alhadidi , Aghadir Mohammad
Keyword(s):  
Pulmonary Hypertension ◽  
Magnesium Sulfate ◽  
Medical Centre ◽  
Persistent Pulmonary Hypertension

Congenital Alveolar Capillary Dysplasia: Rare Cause of Persistent Pulmonary Hypertension

1997 ◽  
Vol 17 (6) ◽  
pp. 959-975 ◽  
Author(s):  
Sibylle Haraida ◽  
Hannelore Lochbuhler ◽  
A. Heger ◽  
A. Nerlich ◽  
J. Diebold ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Persistent Pulmonary Hypertension ◽  
Alveolar Capillary Dysplasia ◽  
Alveolar Capillary

Nitric oxide in persistent pulmonary hypertension of the newborn

1996 ◽  
Vol 72 (3) ◽  
Author(s):  
Humberto H. Fiori ◽  
Renato M. Fiori
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Persistent Pulmonary Hypertension
Sign in / Sign up

Export Citation Format

Share Document