Effect of long-term parenteral administration of empty andl-Dopa-loaded liposomes on the turnover of dopamine and its metabolites in the striatum of mice with experimental Parkinson’s syndrome

1997 ◽  
Vol 123 (2) ◽  
pp. 126-129 ◽  
Author(s):  
V. V. Yurasov ◽  
V. G. Kucheryanu ◽  
V. S. Kudrin ◽  
I. V. Zhigal’tsev ◽  
E. V. Nikushkin ◽  
...  
Keyword(s):  
Parenteral Administration ◽  
Parkinson's Syndrome ◽  
Parkinson’S Syndrome

Preparation of a Carboxymethyl Chitosan-Loaded L-Dopa Composite Nano-Pharmaceutical and Its Therapeutic Effect on Parkinson’s Syndrome

2020 ◽  
Vol 12 (10) ◽  
pp. 1171-1178
Author(s):  
Jie Wu ◽  
Rijun Ren ◽  
Zhaoyou Qiu ◽  
Ning Jiang
Keyword(s):  
Therapeutic Effect ◽  
Carboxymethyl Chitosan ◽  
Neuroprotective Effects ◽  
Parkinson's Syndrome ◽  
Chronic Disability ◽  
Parkinson’S Syndrome ◽  
Midbrain Dopamine ◽  
Effect Of Pd ◽  
The Brain

Parkinson’s syndrome (PD) is the second-most common neurodegenerative disease in the world. The chronic disability of PD and the long-term medication required to treat it imposes a huge economic burden on patients and society. Thus, enhancing the therapeutic effect of PD drugs while reducing the side effects caused by long-term drug use has become a challenge that researchers need to overcome. In this study, a compound drug—levodopa/carboxymethyl chitosan/resveratrol nanoparticles (LDP/CMCS/RVT NPs)—with both sustained release and neuroprotective effects was constructed based on carboxymethyl chitosan. The new LDP compound nano-drug can significantly promote glutathione levels of and superoxide dismutase in the substantia nigra and striatum of mice, while increasing the expression of the brain-derived neurotrophic factor. Based on these findings, LDP/CMCS/RVT NPs is expected to provide a new therapeutic strategy for the recovery of midbrain dopamine deficiency and neuroinflammatory changes in PD patients.

Cognitive Impairment in Parkinson's Syndrome

1971 ◽  
Author(s):  
Armand W. Loranger ◽  
Helen Goodell ◽  
Fletcher McDowell ◽  
John Lee ◽  
Richard D. Sweet
Keyword(s):  
Cognitive Impairment ◽  
Parkinson's Syndrome ◽  
Parkinson’S Syndrome

Autonomic Deficits in Parkinson's Syndrome

1971 ◽  
Vol 24 (1) ◽  
pp. 50-57 ◽  
Author(s):  
O. Appenzeller ◽  
J. E. Goss
Keyword(s):  
Parkinson's Syndrome ◽  
Parkinson’S Syndrome

Herpes Ophthalmicus and Parkinson's Syndrome

BMJ ◽  
1952 ◽  
Vol 1 (4762) ◽  
pp. 820-820
Author(s):  
E. Romanowski
Keyword(s):  
Parkinson's Syndrome ◽  
Parkinson’S Syndrome

Correlation Between Clinical and CT Findings in Parkinson’s Syndrome

1976 ◽  
pp. 244-248 ◽  
Author(s):  
P.-A. Fischer ◽  
P. Jacobi ◽  
E. Schneider ◽  
H. Becker
Keyword(s):  
Parkinson's Syndrome ◽  
Parkinson’S Syndrome ◽  
Ct Findings
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