Time sequence of coagulation data in patients with decompensated liver cirrhosis and suspected disseminated intravascular coagulation

1991 ◽  
Vol 21 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Giorgio Cioni ◽  
Alessandro Cristani ◽  
Enrico Tincani ◽  
Paolo Ventura ◽  
Gabriella Zagni ◽  
...  
1977 ◽  
Vol 8 (1) ◽  
pp. 143-149
Author(s):  
Nobuo SAKURAGAWA ◽  
Kenji NIIYA ◽  
Chozo JIMBO ◽  
Kaoru TAKAHASHI ◽  
Mari HOSHIYAMA ◽  
...  

1987 ◽  
Author(s):  
G Fiori ◽  
G Mombelli ◽  
A Haeberli ◽  
P W Straub

To evaluate the hypothesis of disseminated intravascular coagulation (DIC) in liver cirrhosis (LC), we measured the plasma levels of fibrincpeptide A (FPA) and of fibrinogen-fibrin degradation fragment E (FgE) in 58 patients with LC, and compared the results with those measured in 32 healthy subjects as well as in 42 patients with ongoing fibrin formation and lysis related to acute thromboembolism (TE, n = 33) and overt DIC (n = 9).Results: Mean plasma FPA in LC was 2.4 ng/ml compared to 1.8 ng/ ml in normals (p < 0.05) and 12.2 ng/ml in patients with TE or DIC (p < 0.0001). Mean plasma FgE in LC was 108 ng/ml compared to 31.2 ng/ml in normals (p < 0.0001) and to 616 ng/ml in patients with TE or DIC (p < 0.0001). 15 patients with LC (26%) had hypo-fibrinogenemia (fibrinogen< 1.7 g/L). Among these patients, plasma FPA and FgE were 2.3 and 134 ng/ml, as compared to 22.1 and 1310 ng/ml in patients with hypofibrinogenemia related to DIC (p < 0.0001). Intravenous heparin (60 IU/kg) resulted in a prompt decrease of plasma FPA in 14 patients with TE or DIC from 11.8 to 4.3 ng/ml (p < 0.005), but did not significantly change the FPA level in 15 patients with LC as well as in the healthy subjects. Discussion: The present data indicate that thrombin mediated proteolysis of fibrinogen is only marginally increased in LC regardless of whether hypofibrinogenemia is present or not. The data are strongly against the hypothesis of DIC as a frequent and quantitatively important complication of LC and substantiate the conclusion that a “oonsunption coagulopathy” is not a major determinant of impaired hemostasis in liver cirrhosis.


1992 ◽  
Vol 15 (3) ◽  
pp. 330-335 ◽  
Author(s):  
C.Minke Bakker ◽  
Eduard A.R. Knot ◽  
Jeanne Stibbe ◽  
J.H.Paul Wilson

1995 ◽  
Vol 109 (2) ◽  
pp. 531-539 ◽  
Author(s):  
Francesco Violi ◽  
Domenico Ferro ◽  
Stefania Basili ◽  
Mirella Saliola ◽  
Claudio Quintarelli ◽  
...  

1987 ◽  
Vol 151 (3) ◽  
pp. 269-274
Author(s):  
YOSHIAKI YAJIMA ◽  
MASAO OTSUKI ◽  
HIROSHI SUZUKI ◽  
KAZUO MORI ◽  
YOSHIO GOTO

Critical Care ◽  
2015 ◽  
Vol 19 (Suppl 1) ◽  
pp. P377
Author(s):  
A Drolz ◽  
T Horvatits ◽  
K Rutter ◽  
K Roedl ◽  
S Kluge ◽  
...  

1985 ◽  
Vol 37 (2) ◽  
pp. 287-294 ◽  
Author(s):  
F. Marongiu ◽  
A.M. Mamusa ◽  
G. Mameli ◽  
G. Mulas ◽  
A. Solinas ◽  
...  

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