Role of germinal centers in the generation of B cell memory

1985 ◽  
Vol 30 (3) ◽  
pp. 196-202 ◽  
Author(s):  
R. F. Coico ◽  
G. J. Thorbecke
Keyword(s):  
B Cell ◽  
Germinal Centers ◽  
Cell Memory ◽  
B Cell Memory

scholarly journals gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 ◽  
Vol 180 (1) ◽  
pp. 157-163 ◽  
Author(s):  
T M Foy ◽  
J D Laman ◽  
J A Ledbetter ◽  
A Aruffo ◽  
E Claassen ◽  
...  
Keyword(s):  
B Cell ◽  
Germinal Center ◽  
Germinal Centers ◽  
Antibody Responses ◽  
Cell Memory ◽  
Specific Memory ◽  
B Cell Memory ◽  
Germinal Center Formation

gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti-gp39 in vivo inhibits both primary and secondary antibody formation to TD, but not T-independent antigens. However, the role of this receptor-ligand pair in the development of germinal centers and the generation of B cell memory is as yet undefined. Using an antibody to gp39, this study examines the in vivo requirement for gp39-CD40 interactions in the induction of germinal center formation, as well as in the generation of B cell memory. Animals were immunized, treated in vivo with anti-gp39, and evaluated using immunohistochemical staining for the presence of splenic germinal centers 9-11 d after immunization. The results demonstrate that the formation of germinal centers was completely inhibited as a result of treatment with anti-gp39. Moreover, adoptive transfer experiments demonstrate that the generation of antigen-specific memory B cells is also inhibited as a consequence of blocking gp39-CD40 interactions. Taken together, the data demonstrate that gp39-CD40 interactions are critical not only for the generation of antibody responses, but also in the development of B cell memory.

scholarly journals Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19

1998 ◽  
Vol 188 (1) ◽  
pp. 145-155 ◽  
Author(s):  
Thomas Fehr ◽  
Robert C. Rickert ◽  
Bernhard Odermatt ◽  
Jürgen Roes ◽  
Klaus Rajewsky ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
B Cell ◽  
Cell Activation ◽  
Antibody Responses ◽  
B Cell Activation ◽  
Protein Antigens ◽  
Cell Memory ◽  
B Cell Memory

Coligation of CD19, a molecule expressed during all stages of B cell development except plasmacytes, lowers the threshold for B cell activation with anti-IgM by a factor of 100. The cytoplasmic tail of CD19 contains nine tyrosine residues as possible phosphorylation sites and is postulated to function as the signal transducing element for complement receptor (CR)2. Generation and analysis of CD19 gene–targeted mice revealed that T cell–dependent (TD) antibody responses to proteinaceous antigens were impaired, whereas those to T cell–independent (TI) type 2 antigens were normal or even augmented. These results are compatible with earlier complement depletion studies and the postulated function of CD19. To analyze the role of CD19 in antiviral antibody responses, we immunized CD19−/− mice with viral antigens of TI-1, TI-2, and TD type. The effect of CD19 on TI responses was more dependent on antigen dose and replicative capacity than on antigen type. CR blocking experiments confirmed the role of CD19 as B cell signal transducer for complement. In contrast to immunization with protein antigens, infection of CD19−/− mice with replicating virus led to generation of specific germinal centers, which persisted for >100 d, whereas maintenance of memory antibody titers as well as circulating memory B cells was fully dependent on CD19. Thus, our study confirms a costimulatory role of CD19 on B cells under limiting antigen conditions and indicates an important role for B cell memory.

B cell memory to thymus-independent antigens type 1 and type 2: the role of lipopolysaccharide in B memory induction

1988 ◽  
Vol 18 (9) ◽  
pp. 1417-1424 ◽  
Author(s):  
Jun Zhang ◽  
Yong-Jun Liu ◽  
Ian C. M. Maclennan ◽  
David Gray ◽  
Peter J. L. Lane
Keyword(s):  
B Cell ◽  
Cell Memory ◽  
B Cell Memory

The Role of B-Cell Memory in Secondary IgG and IgM Responses

1976 ◽  
Vol 5 (3) ◽  
pp. 213-219 ◽  
Author(s):  
I. SEPPALA ◽  
M. HURME ◽  
H. SARVAS ◽  
O. MAKELA
Keyword(s):  
B Cell ◽  
Cell Memory ◽  
B Cell Memory

B cell memory and the role of apoptosis in its formation

2011 ◽  
Vol 48 (11) ◽  
pp. 1301-1306 ◽  
Author(s):  
Ingela Vikstrom ◽  
David M. Tarlinton
Keyword(s):  
B Cell ◽  
Cell Memory ◽  
B Cell Memory

scholarly journals Antiviral B Cell Memory in the Absence of Mature Follicular Dendritic Cell Networks and Classical Germinal Centers in TNFR1−/−Mice

2000 ◽  
Vol 164 (2) ◽  
pp. 768-778 ◽  
Author(s):  
U. Karrer ◽  
C. López-Macías ◽  
A. Oxenius ◽  
B. Odermatt ◽  
M. F. Bachmann ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
B Cell ◽  
Follicular Dendritic Cell ◽  
Germinal Centers ◽  
Cell Memory ◽  
B Cell Memory ◽  
Follicular Dendritic ◽  
Cell Networks
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