THREE COMPARATIVE STUDIES WITH TOLMETIN IN RHEUMATOID ARTHRITIS

InPharma ◽  
1977 ◽  
Vol 100 (1) ◽  
pp. 10-10
1963 ◽  
Vol 03 (01) ◽  
pp. 25-38
Author(s):  
Manuel Tubis ◽  
William Blahd ◽  
John Endow

SummaryA study of the removal of I131-labeled Congo red from the blood of amyloid, non-amyloid, multiple myeloma, rheumatoid arthritis and other patients is presented. The percentage removal of the labeled dye shows the same variation reported by many other workers using Bennhold’s test and its modifications.However, there seems to be a positive correlation between the percentage removal of the labeled dye and the presence of amyloid as revealed by biopsy and autopsy. The half-time of disappearance is also correlated with the amyloidosis.The availability of the I131-labeled dye permits the use of very small weights of the dye thereby drastically reducing the possibility of toxic and sometimes fatal reactions encountered with the unlabeled dye. The I131 present permits easy quantitation of the dye in the blood without separation of plasma and obviates the need of fasting. It also permits external counting and scanning of deposits in the organs containing the dye.The availability and use of the labeled dye may stimulate more comparative studies of the removal of the dye from the blood correlated with biopsy and autopsy findings.


1978 ◽  
Vol 21 (6) ◽  
pp. 699-703 ◽  
Author(s):  
Anna Maria Filipowicz‐Sosnowska ◽  
Katarzyna Roztropowicz‐Denisiewicz ◽  
C. Julian Rosenthal ◽  
John Baum

Ensho ◽  
1987 ◽  
Vol 7 (5) ◽  
pp. 419-423
Author(s):  
Shigehisa Aoki ◽  
Koji Ikuta ◽  
Tsunemasa Nonogaki ◽  
Kiyokazu Nagamatsu

2019 ◽  
Vol 12 (5) ◽  
pp. 353-361
Author(s):  
Vasileios Samdanis ◽  
Gopikanthan Manoharan ◽  
Robert W Jordan ◽  
Adam C Watts ◽  
Paul Jenkins ◽  
...  

Background Total elbow arthroplasty (TEA) is the established treatment for end-stage rheumatoid arthritis but improved surgical techniques have resulted in expanded indications. The aim of this study is to review the literature to evaluate the evolution of surgical indications for TEA. Methods A systematic review of PubMed and EMBASE databases was conducted. Case series and comparative studies reporting results after three types of primary TEA were eligible for inclusion. Results Forty-nine eligible studies were identified ( n = 1995). The number of TEA cases published annually increased from 6 cases in 1980 to 135 cases in 2008. The commonest indication for TEA throughout the review period was rheumatoid arthritis but its annual proportion reduced from 77% to 50%. The mean Mayo Elbow Performance Score significantly improved for all indications. Three comparative studies reported statistically improved functional outcomes in rheumatoid arthritis over the trauma sequelae group. Complication and revision rates varied; rheumatoid arthritis 5.2–30.9% and 11–13%, acute fracture 0–50% and 10–11%, trauma sequelae 14.2–50% and 0–30%, osteoarthritis 50% and 11%, respectively. Discussion TEA can provide functional improvements in inflammatory arthritis, acute fractures, trauma sequelae and miscellaneous indications. Long-term TEA survivorship appears satisfactory in rheumatoid arthritis and fracture cases; however, further research into alternative surgical indications is still required.


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