Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents

2011 ◽  
Vol 21 (10) ◽  
pp. 3161-3169 ◽  
Author(s):  
M. S. R. Murty ◽  
B. Ramalingeswara Rao ◽  
Kesur R. Ram ◽  
J. S. Yadav ◽  
Jayesh Antony ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Preliminary Evaluation ◽  
Evaluation Activity ◽  
Substituted Piperazine

Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents

2010 ◽  
Vol 20 (5) ◽  
pp. 576-586 ◽  
Author(s):  
M. S. R. Murty ◽  
Kesur R. Ram ◽  
Rayudu Venkateswara Rao ◽  
J. S. Yadav ◽  
Janapala Venkateswara Rao ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Preliminary Evaluation

Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents

2011 ◽  
Vol 34 (2) ◽  
pp. 181-189 ◽  
Author(s):  
Aurelio Romero-Castro ◽  
Ismael León-Rivera ◽  
Laura Citlalli Ávila-Rojas ◽  
Gabriel Navarrete-Vázquez ◽  
Alejandro Nieto-Rodríguez
Keyword(s):  
Anticancer Agents ◽  
Benzimidazole Derivatives ◽  
Preliminary Evaluation

Synthesis and preliminary evaluation of 3-thiocyanato-1H-indoles as potential anticancer agents

2016 ◽  
Vol 118 ◽  
pp. 21-26 ◽  
Author(s):  
Margiani P. Fortes ◽  
Paulo B.N. da Silva ◽  
Teresinha G. da Silva ◽  
Teodoro S. Kaufman ◽  
Gardenia C.G. Militão ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Preliminary Evaluation

Preliminary Evaluation of a Weibull Function for Fitting Slow-Component Eye Velocity over the Time Course of Caloric-Induced Nystagmus

1989 ◽  
Vol 32 (3) ◽  
pp. 681-687 ◽  
Author(s):  
C. Formby ◽  
B. Albritton ◽  
I. M. Rivera
Keyword(s):  
Time Course ◽  
Slow Component ◽  
Weibull Function ◽  
Preliminary Evaluation ◽  
Mathematical Function ◽  
Before And After ◽  
Best Fitting ◽  
Eye Velocity ◽  
Fitting Parameters ◽  
Weibull Equation

We describe preliminary attempts to fit a mathematical function to the slow-component eye velocity (SCV) over the time course of caloric-induced nystagmus. Initially, we consider a Weibull equation with three parameters. These parameters are estimated by a least-squares procedure to fit digitized SCV data. We present examples of SCV data and fitted curves to show how adjustments in the parameters of the model affect the fitted curve. The best fitting parameters are presented for curves fit to 120 warm caloric responses. The fitting parameters and the efficacy of the fitted curves are compared before and after the SCV data were smoothed to reduce response variability. We also consider a more flexible four-parameter Weibull equation that, for 98% of the smoothed caloric responses, yields fits that describe the data more precisely than a line through the mean. Finally, we consider advantages and problems in fitting the Weibull function to caloric data.

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