scholarly journals Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents

2020 ◽  
Vol 8 ◽  
Author(s):  
Roberta Listro ◽  
Silvia Stotani ◽  
Giacomo Rossino ◽  
Marta Rui ◽  
Alessio Malacrida ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Chemical Space ◽  
Design And Synthesis ◽  
Space Design ◽  
Piperazine Derivatives ◽  
Substituted Piperazine

Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship

2019 ◽  
Vol 19 (7) ◽  
pp. 842-874 ◽  
Author(s):  
Harbinder Singh ◽  
Nihar Kinarivala ◽  
Sahil Sharma
Keyword(s):  
Anticancer Agents ◽  
Cancer Drug ◽  
Design And Synthesis ◽  
Cancer Drug Discovery ◽  
Dual Targeting ◽  
Structure Activity ◽  
Anti Cancer ◽  
Dual Inhibitors ◽  
Recent Trends ◽  
Synthetic Routes

We live in a world with complex diseases such as cancer which cannot be cured with one-compound one-target based therapeutic paradigm. This could be due to the involvement of multiple pathogenic mechanisms. One-compound-various-targets stratagem has become a prevailing research topic in anti-cancer drug discovery. The simultaneous interruption of two or more targets has improved the therapeutic efficacy as compared to the specific targeted based therapy. In this review, six types of dual targeting agents along with some interesting strategies used for their design and synthesis are discussed. Their pharmacology with various types of the molecular interactions within their specific targets has also been described. This assemblage will reveal the recent trends and insights in front of the scientific community working in dual inhibitors and help them in designing the next generation of multi-targeted anti-cancer agents.

Design and Synthesis of Novel β-Carboline Linked Amide Derivatives as Anticancer Agents

2019 ◽  
Vol 89 (3) ◽  
pp. 511-516 ◽  
Author(s):  
B. Ravinaik ◽  
D. Ramachandran ◽  
M. V. Basaveswara Rao
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis ◽  
Amide Derivatives

Design and Synthesis of Sulfonamide‐Attached 2‐(Isoxazol‐3‐yl)‐1 H ‐imidazoles as Anticancer Agents

2020 ◽  
Vol 5 (26) ◽  
pp. 7919-7922
Author(s):  
Satheesh Kumar Dende ◽  
Raghu Babu Korupolu ◽  
Krishnakanth Reddy Leleti
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis

scholarly journals Synthesis and Antimicrobial Activity of Some New Piperazine Derivaties Containing Aryl Sulfonyloxy Group

2004 ◽  
Vol 1 (2) ◽  
pp. 93-98 ◽  
Author(s):  
H. S. Patel ◽  
H. D. Desai ◽  
H. J. Mistry
Keyword(s):  
Antimicrobial Activity ◽  
Acetyl Chloride ◽  
Condensation Reaction ◽  
Piperazine Derivatives ◽  
Substituted Piperazine

NovelN-substituted piperazine derivatives containing sulfonyloxy aniline moiety have been prepared. The various 4-sulfonyloxy aniline (SA) derivatives (2a-h) have been prepared by the condensation reaction ofN-Acetyl Sulfanilyl chloride (ASC) and sodium phenates followed by hydrolysis. The SA derivatives are then reacted with chloro acetyl chloride to give corresponding (N-Chloroacetyl) derivatives (3a-h). These derivatives are then reacted withN-phenyl piperazine to yield the corresponding piperazine derivatives (4a-h).

scholarly journals Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Vincenza Barresi ◽  
Carmela Bonaccorso ◽  
Domenico A. Cristaldi ◽  
Maria N. Modica ◽  
Nicolò Musso ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Cancer Cell Line ◽  
Breast Cancer Cell Lines ◽  
Design And Synthesis ◽  
Human Breast Cell ◽  
Mcf 7

Recent drug discovery efforts are highly focused towards identification, design, and synthesis of small molecules as anticancer agents. With this aim, we recently designed and synthesized novel compounds with high efficacy and specificity for the treatment of breast tumors. Based on the obtained results, we constructed a Volsurf+ (VS+) model using a dataset of 59 compounds able to predict the in vitro antitumor activity against MCF-7 cancer cell line for new derivatives. In the present paper, in order to further verify the robustness of this model, we report the results of the projection of more than 150 known molecules and 9 newly synthesized compounds. We predict their activity versus MCF-7 cell line and experimentally verify the in silico results for some promising chosen molecules in two human breast cell lines, MCF-7 and MDA-MB-231.

Design and synthesis of some new piritrexim analogs as potential anticancer agents

2017 ◽  
Vol 44 (2) ◽  
pp. 749-767 ◽  
Author(s):  
Poojali P. Warekar ◽  
Kirti T. Patil ◽  
Priyanka T. Patil ◽  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis
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