Relationships Between Molecular Structure and Chromosomal Aberrations in In Vitro Human Lymphocytes Induced by Substituted Nitrobenzenes

1996 ◽  
Vol 57 (3) ◽  
pp. 349-353 ◽  
Author(s):  
Q.-G. Huang ◽  
L.-R. Kong ◽  
Y.-B. Liu ◽  
L.-S. Wang
Keyword(s):  
Molecular Structure ◽  
Chromosomal Aberrations ◽  
Human Lymphocytes

scholarly journals Evaluation of mutagenicity, genotoxicity and chronic toxicity of antiviral drug imidazolyl ethanamide pentandioic acid in in vitro and in vivo test systems

2021 ◽  
Vol 98 (5) ◽  
pp. 548-557
Author(s):  
E. A. Jain ◽  
D. Pleimes ◽  
A. A. Globenko
Keyword(s):  
Oral Administration ◽  
Chromosomal Aberrations ◽  
Ames Test ◽  
Chronic Toxicity ◽  
Micronucleus Test ◽  
Human Lymphocytes ◽  
Antiviral Drug ◽  
Systemic Exposure

Introduction. The antiviral properties of imidazolyl ethanamide pentandioic acid (IPA), the active compound of the drug product, has been proven in various experimental models. However, the literature data on the toxicological properties of IPA are limited.Purpose. To evaluate mutagenic and genotoxic properties in in vitro and in vivo models, as well as to study the toxicity of IPA following chronic oral administration to rats and dogs.Materials and methods. Mutagenic and genotoxic properties of IPA were assessed using the Ames test, the test of chromosomal aberrations in human lymphocytes, and the micronucleus test in rats. The chronic toxicity of IPA was studied in Sprague Dawley rats and beagle dogs of both sexes, to which IPA was administered orally at doses of 30-300 mg/kg/day for 26 and 39 weeks, respectively.Results and discussion. In the Ames test, the addition of IPA up to the maximum dose (5000 mcg/plate) did not result in the increase in the number of revertant colonies. At a concentration of up to 5000 mcg/ml, IPA did not cause chromosomal aberrations in human leukocytes. At doses doses ≤ 2000 mg/kg, IPA did not increase the amount of micronuclei in the bone marrow of rats. In chronic experiments, animals tolerated the administration of IPA well: the dose without an observed effect (NOEL) for rats and dogs was 300 mg/kg/day.Conclusion. IPA did not show mutagenic and genotoxic properties in standard in vitro and in vivo tests. With chronic oral administration to rats and dogs, NOEL IPA equal to 300 mg/kg/day provided a systemic exposure that was 8-10 and 41-65 times higher than that in humans, respectively. The results obtained allow us to consider the safety profile of the prolonged use in humans as favorable.

Chromosomal aberrations in human lymphocytes exposed in vitro to enrofloxacin and ciprofloxacin

1999 ◽  
Vol 104 (1-2) ◽  
pp. 43-48 ◽  
Author(s):  
N Gorla ◽  
H Garcı́a Ovando ◽  
I Larripa
Keyword(s):  
Chromosomal Aberrations ◽  
Human Lymphocytes

Chromosomal aberrations induced by chrysotile and crocidolite in human lymphocytes in vitro

1983 ◽  
Vol 122 (3-4) ◽  
pp. 397-402 ◽  
Author(s):  
Federico Valerio ◽  
Marcella de Ferrari ◽  
Laura Ottaggio ◽  
Enrica Repetto ◽  
Leonardo Santi
Keyword(s):  
Chromosomal Aberrations ◽  
Human Lymphocytes
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