Vasopeptidase inhibition attenuates proteinuria and podocyte injury in Zucker diabetic fatty rats

2007 ◽  
Vol 375 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Sabine Fredersdorf ◽  
Joachim Weil ◽  
Coskun Ulucan ◽  
Christoph Birner ◽  
Roland Büttner ◽  
...  
Keyword(s):  
Podocyte Injury ◽  
Vasopeptidase Inhibition ◽  
Zucker Diabetic Fatty Rats

scholarly journals Nephroprotection in Zucker diabetic fatty rats by vasopeptidase inhibition is partly bradykinin B2 receptor dependent

2004 ◽  
Vol 143 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Stefan Schäfer ◽  
Hans-Ludwig Schmidts ◽  
Markus Bleich ◽  
Andreas E Busch ◽  
Wolfgang Linz
Keyword(s):  
Bradykinin B2 Receptor ◽  
Vasopeptidase Inhibition ◽  
Zucker Diabetic Fatty Rats

scholarly journals Podocyte Injury Promotes Progressive Nephropathy in Zucker Diabetic Fatty Rats

2002 ◽  
Vol 82 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Sachi Hoshi ◽  
Yujing Shu ◽  
Fusayo Yoshida ◽  
Tomoko Inagaki ◽  
Jiro Sonoda ◽  
...  
Keyword(s):  
Podocyte Injury ◽  
Zucker Diabetic Fatty Rats

Rosuvastatin Ameliorates Obesity and Proteinuria in Zucker Diabetic Fatty Rats

2013 ◽  
Vol 13 (2) ◽  
pp. 144-149 ◽  
Author(s):  
Hironori Nakagami ◽  
Takashi Shimosato ◽  
Munehisa Shimamura ◽  
Ryuichi Morishita
Keyword(s):  
Zucker Diabetic Fatty Rats

Glomerular subepithelial microparticles - a footprint for podocyte injury

2021 ◽  
pp. 1-7
Author(s):  
Yon Hee Kim ◽  
Kyu Ha Huh ◽  
Beom Jin Lim ◽  
Beom Seok Kim ◽  
Yu Seun Kim ◽  
...  
Keyword(s):  
Podocyte Injury

scholarly journals Effects of tacrolimus on autophagy protein LC3 in puromycin-damaged mouse podocytes

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052097142
Author(s):  
Xiao-qing Yang ◽  
Sheng-you Yu ◽  
Li Yu ◽  
Lin Ge ◽  
Yao Zhang ◽  
...  
Keyword(s):  
Fluorescence Intensity ◽  
Light Chain ◽  
In Vitro Model ◽  
Group Versus ◽  
Podocyte Injury ◽  
Apoptosis Rate ◽  
Protein Levels ◽  
Vitro Model ◽  
Intercellular Connections

Objective To investigate the mechanism through which tacrolimus, often used to treat refractory nephropathy, protects against puromycin-induced podocyte injury. Methods An in vitro model of puromycin-induced podocyte injury was established by dividing podocytes into three groups: controls, puromycin only (PAN group), and puromycin plus tacrolimus (FK506 group). Podocyte morphology, number, apoptosis rate and microtubule associated protein 1 light chain 3 alpha ( LC3) expression were compared. Results Puromycin caused podocyte cell body shrinkage and loose intercellular connections, but podocyte morphology in the FK506 group was similar to controls. The apoptosis rate was lower in the FK506 group versus PAN group. The low level of LC3 mRNA observed in untreated podocytes was decreased by puromycin treatment; however, levels of LC3 mRNA were higher in the FK506 group versus PAN group. Although LC3-I and LC3-II protein levels were decreased by puromycin, levels in the FK506 group were higher than the PAN group. Fewer podocyte autophagosomes were observed in the control and FK506 groups versus the PAN group. Cytoplasmic LC3-related fluorescence intensity was stronger in control and FK506 podocytes versus the PAN group. Conclusions Tacrolimus inhibited puromycin-induced mouse podocyte damage by regulating LC3 expression and enhancing autophagy.

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