Involvement of soluble guanylate cyclase and calcium-activated potassium channels in the long-lasting hyporesponsiveness to phenylephrine induced by nitric oxide in rat aorta

2000 ◽  
Vol 361 (5) ◽  
pp. 477-483 ◽  
Author(s):  
M.R. Terluk ◽  
J.E. da Silva-Santos ◽  
J. Assreuy
Keyword(s):  
Nitric Oxide ◽  
Potassium Channels ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Rat Aorta ◽  
Calcium Activated Potassium Channels

Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite

1996 ◽  
Vol 271 (3) ◽  
pp. H1262-H1266 ◽  
Author(s):  
E. P. Wei ◽  
H. A. Kontos ◽  
J. S. Beckman
Keyword(s):  
Hydrogen Peroxide ◽  
Potassium Channels ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Calcium Activated Potassium Channels ◽  
Cerebral Arterioles ◽  
Cerebral Vasodilation ◽  
Vasodilator Action ◽  
Ly 83583 ◽  
Dose Dependent

We investigated the role of potassium channels in the vasodilator action of hydrogen peroxide, peroxynitrite, and superoxide on cerebral arterioles. We studied the effect of topical application of these agents in anesthetized cats equipped with cranial windows. Hydrogen peroxide and peroxynitrite induced dose-dependent dilation that was inhibited by glyburide, an inhibitor of ATP-sensitive potassium channels. Superoxide, generated by xanthine oxidase acting on xanthine in the presence of catalase, also induced dose-dependent dilation of cerebral arterioles that was unaffected by glyburide but inhibited completely by tetraethylammonium chloride, an inhibitor of calcium-activated potassium channels. The vasodilations from hydrogen peroxide, peroxynitrite, or superoxide were unaffected by inhibition of soluble guanylate cyclase with LY-83583. The findings provide pharmacological evidence that hydrogen peroxide and peroxynitrite reversibly dilate cerebral arterioles by activating ATP-sensitive potassium channels, probably through an oxidant mechanism, whereas superoxide dilates cerebral arterioles by opening calcium-activated potassium channels. Activation of soluble guanylate cyclase is not a mediator of the vasodilator action of these agents in cerebral arterioles.

Nitric Oxide- and Heme-Independent Activation of Soluble Guanylate Cyclase Attenuates Peroxynitrite-Induced Endothelial Dysfunction in Rat Aorta

2012 ◽  
Vol 18 (1) ◽  
pp. 70-77 ◽  
Author(s):  
Sevil Korkmaz ◽  
Sivakkanan Loganathan ◽  
Beatrice Mikles ◽  
Tamás Radovits ◽  
Enikő Barnucz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Rat Aorta

Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models

2010 ◽  
Vol 28 (8) ◽  
pp. 1666-1675 ◽  
Author(s):  
Yuliya Sharkovska ◽  
Philipp Kalk ◽  
Bettina Lawrenz ◽  
Michael Godes ◽  
Linda Sarah Hoffmann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Organ Damage ◽  
Stimulation Of

YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice

1997 ◽  
Vol 320 (2-3) ◽  
pp. 161-166 ◽  
Author(s):  
Che-Ming Teng ◽  
Chin-Chung Wu ◽  
Feng-Nien Ko ◽  
Fang-Yu Lee ◽  
Sheng-Chu Kuo
Keyword(s):  
Nitric Oxide ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase
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