Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats

2003 ◽  
Vol 170 (3) ◽  
pp. 320-331 ◽  
Author(s):  
Catharine A. Winstanley ◽  
Jeffrey W. Dalley ◽  
David E. H. Theobald ◽  
Trevor W. Robbins
Keyword(s):  
Delay Discounting ◽  
Impulsive Choice

Delay Discounting and Impulsive Choice in the Rat

2007 ◽  
Vol 39 (1) ◽  
Author(s):  
Adam C. Mar ◽  
Trevor W. Robbins
Keyword(s):  
Delay Discounting ◽  
Impulsive Choice

scholarly journals Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task.

2014 ◽  
Vol 128 (4) ◽  
pp. 419-429 ◽  
Author(s):  
Marci R. Mitchell ◽  
Virginia G. Weiss ◽  
Dominique J. Ouimet ◽  
Rita A. Fuchs ◽  
Drake Morgan ◽  
...  
Keyword(s):  
Delay Discounting ◽  
Impulsive Choice ◽  
Self Administration

scholarly journals Sex differences in the reduction of impulsive choice (delay discounting) for cocaine in rats with atomoxetine and progesterone

2016 ◽  
Vol 233 (15-16) ◽  
pp. 2999-3008 ◽  
Author(s):  
John R. Smethells ◽  
Natashia L. Swalve ◽  
Lynn E. Eberly ◽  
Marilyn E. Carroll
Keyword(s):  
Sex Differences ◽  
Delay Discounting ◽  
Impulsive Choice

scholarly journals Global Cerebral Ischemia in Male Long Evans Rats Impairs Dopaminergic/ΔFosB Signalling in the Mesocorticolimbic Pathway Without Altering Delay Discounting Rates

2022 ◽  
Vol 15 ◽  
Author(s):  
Alexandre Morin ◽  
Marilou Poitras ◽  
Hélène Plamondon
Keyword(s):  
Cerebral Ischemia ◽  
Delay Discounting ◽  
Basolateral Amygdala ◽  
Global Cerebral Ischemia ◽  
Impulsive Choice ◽  
Nucleus Accumbens Core ◽  
Defensive Responses ◽  
Post Surgery ◽  
Corticosterone Secretion ◽  
Long Evans

Global cerebral ischemia (GCI) in rats has been shown to promote exploration of anxiogenic zones of the Elevated-Plus Maze (EPM) and Open Field Test (OFT). This study investigated changes in impulsive choice and/or defensive responses as possible contributors of heightened anxiogenic exploration observed after ischemia. Impulsivity was assessed using delay discounting (DD) paradigms, while the Predator Odour Test (PO) served to assess changes in defensive responses towards a naturally aversive stimulus. Male Long Evans rats underwent 9 days of autoshaping training and 24 days of DD training prior to GCI or sham surgery (n = 9/group). Post-surgery, rats completed the OFT, EPM, and PO, followed by 6 days of DD sessions. Blood droplets served to evaluate corticosterone secretion associated with PO exposure. With impulsivity being regulated through mesocorticolimbic monoaminergic pathways, we also characterised post-ischemic changes in the expression of dopamine D2 receptors (DRD2), dopamine transporters (DAT), and 1FosB in the basolateral amygdala (BLA), nucleus accumbens core (NAcC) and shell (NAcS), and ventromedial prefrontal cortex (vmPFC) using immunohistofluorescence. Our findings revealed no impact of GCI on delay discounting rates, while PO approach behaviours were minimally affected. Nonetheless, GCI significantly reduced DRD2 and ΔFosB-ir in the NAcS and NAcC, respectively, while DAT-ir was diminished in both NAc subregions. Collectively, our findings refine the understanding of cognitive-behavioural and biochemical responses following stroke or cardiac arrest. They support significant alterations to the dopaminergic mesocorticolimbic pathway after ischemia, which are not associated with altered impulsive choice in a DD task but may influence locomotor exploration of the OFT and EPM.

scholarly journals Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice during Delay Discounting Behavior

2019 ◽  
Vol 39 (16) ◽  
pp. 3108-3118 ◽  
Author(s):  
Deirdre A. Sackett ◽  
Travis M. Moschak ◽  
Regina M. Carelli
Keyword(s):  
Delay Discounting ◽  
Cortical Neurons ◽  
Impulsive Choice ◽  
Reward Value
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