Acute intranasal dopamine application counteracts the reversal learning deficit of spontaneously hypertensive rats in an attentional set-shifting task

2021 ◽  
Author(s):  
Jay-Shake Li ◽  
Shan-Sung Yang ◽  
Joseph P. Huston ◽  
Owen Y. Chao ◽  
Yi-Mei Yang ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Spontaneously Hypertensive Rats ◽  
Set Shifting ◽  
Hypertensive Rats ◽  
Learning Deficit ◽  
Attentional Set ◽  
Spontaneously Hypertensive ◽  
Attentional Set Shifting ◽  
Set Shifting Task

scholarly journals Automatic Intra-/Extra-Dimensional Attentional Set-Shifting Task in Adolescent Mice

2021 ◽  
Vol 15 ◽  
Author(s):  
Mariasole Ciampoli ◽  
Diego Scheggia ◽  
Francesco Papaleo
Keyword(s):  
Executive Functions ◽  
Neuropsychological Test ◽  
Wisconsin Card Sorting Test ◽  
Set Shifting ◽  
Card Sorting ◽  
Attentional Set ◽  
Attentional Set Shifting ◽  
Wisconsin Card Sorting ◽  
Sorting Test ◽  
Set Shifting Task

Adolescence is a developmental period crucial for the maturation of higher-order cognitive functions. Indeed, adolescence deficits in executive functions are strong predictors of increased vulnerability to several mental disabilities later in life. Here, we tested adolescent mice in a fully-automated attentional set-shifting task equivalent to the humans’ Wisconsin Card Sorting Test (WCST) and the Cambridge Neuropsychological Test Automated Battery Intra-/Extra-Dimensional set-shift task (ID/ED). Compared to an adult, adolescent mice required more time to complete the task (≈16 days), and a higher percentage failed to finish the entire task. Nevertheless, adolescent mice completing this demanding task showed an increased effort in solving the extradimensional shift stage (EDS) compared to previous stages. Moreover, we found that this paradigm can be used to detect early cognitive dysfunctions in adolescent genetically modified mice. Thus, this automatic paradigm provides a further tool to assess attentional control in adolescent mice, and the development of dysfunctional executive functions from adolescence to adulthood.

The Ultimate Intra-/Extra-Dimensional Attentional Set-Shifting Task for Mice

2014 ◽  
Vol 75 (8) ◽  
pp. 660-670 ◽  
Author(s):  
Diego Scheggia ◽  
Audrey Bebensee ◽  
Daniel R. Weinberger ◽  
Francesco Papaleo
Keyword(s):  
Set Shifting ◽  
Attentional Set ◽  
Attentional Set Shifting ◽  
Set Shifting Task

scholarly journals The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice

2010 ◽  
Vol 214 (4) ◽  
pp. 911-921 ◽  
Author(s):  
Tomasz Kos ◽  
Agnieszka Nikiforuk ◽  
Dominik Rafa ◽  
Piotr Popik
Keyword(s):  
Nmda Receptor ◽  
Task Performance ◽  
Nmda Receptor Antagonists ◽  
Set Shifting ◽  
Receptor Antagonists ◽  
Attentional Set ◽  
Attentional Set Shifting ◽  
Set Shifting Task
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