Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting

2021 ◽  
pp. 107477
Author(s):  
Daniela Cernotova ◽  
Ales Stuchlik ◽  
Jan Svoboda
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Reversal Learning ◽  
Ventral Hippocampus ◽  
Set Shifting ◽  
Attentional Set ◽  
Spatial Reversal ◽  
Attentional Set Shifting

scholarly journals The claustrum-medial prefrontal cortex network controls attentional set-shifting

2020 ◽  
Author(s):  
Leon Fodoulian ◽  
Olivier Gschwend ◽  
Chieko Huber ◽  
Sophie Mutel ◽  
Rodrigo F. Salazar ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Cognitive Deficits ◽  
Pyramidal Cells ◽  
Excitatory Input ◽  
Set Shifting ◽  
Attentional Set ◽  
Attentional Set Shifting ◽  
Reciprocal Connections

SUMMARYIn various mental disorders, dysfunction of the prefrontal cortex contributes to cognitive deficits. Here we studied how the claustrum (CLA), a nucleus sharing reciprocal connections with the cortex, may participate in these cognitive impairments. We show that specific ensembles of CLA and of medial prefrontal cortex (mPFC) neurons are activated during a task requiring cognitive control such as attentional set-shifting, i.e. the ability to shift attention towards newly relevant stimulus-reward associations while disengaging from irrelevant ones. CLA neurons exert a direct excitatory input on mPFC pyramidal cells, and chemogenetic inhibition of CLA neurons suppresses the formation of specific mPFC assemblies during attentional set-shifting. Furthermore, impairing the recruitment of specific CLA assemblies through opto/chemogenetic manipulations prevents attentional set-shifting. In conclusion, we propose that the CLA controls the reorganization of mPFC ensembles to enable attentional set-shifting, emphasizing a potential role of the CLA-mPFC network in attentional dysfunctions.

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