Quantitative determination of glucose in blood plasma by homonuclear proton decoupled water attenuation transverse relaxation Carr-Purcell-Meiboom-Gill (WATR-HDCPMG) NMR spectroscopy

1998 ◽  
Vol 361 (5) ◽  
pp. 500-503
Author(s):  
W. Y. Choy ◽  
S. C. F. Au-Yeung ◽  
S. Y. Fan ◽  
W. L. A. K. Chiu ◽  
C. S. Cockram
Keyword(s):  
Nmr Spectroscopy ◽  
Quantitative Determination ◽  
Blood Plasma ◽  
Transverse Relaxation ◽  
In Blood Plasma

Quantitative determination of glucose in blood plasma and in fruit juices by combined WATR-CPMG 1H NMR spectroscopy

1992 ◽  
Vol 64 (21) ◽  
pp. 2570-2574 ◽  
Author(s):  
Shiyan. Fan ◽  
W. Y. Choy ◽  
S. L. Lam ◽  
S. C. F. Au-Yeung ◽  
L. Tsang ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Quantitative Determination ◽  
Blood Plasma ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Fruit Juices ◽  
In Blood Plasma

Development and Validation of an LC/MS Method for Quantitative Determination of Thiamine in Blood Plasma

2013 ◽  
Vol 46 (12) ◽  
pp. 742-744 ◽  
Author(s):  
O. A. Tashirova ◽  
G. V. Ramenskaya ◽  
A. M. Vlasov ◽  
M. R. Khaitov
Keyword(s):  
Quantitative Determination ◽  
Blood Plasma ◽  
Development And Validation ◽  
In Blood Plasma

METHOD DEVELOPMENT FOR QUANTITATIVE DETERMINATION OF MONOMECAINE IN BLOOD PLASMA BY HPLC-UV

2020 ◽  
Vol 22 (2) ◽  
pp. 5-10
Author(s):  
Саидов Н.Д. ◽  
◽  
Карпенко Ю.Н. ◽  
Малкова Т.Л. ◽  
Keyword(s):  
Quantitative Determination ◽  
Blood Plasma ◽  
Method Development ◽  
In Blood Plasma

scholarly journals Individual features of the pharmacokinetics of fludarabin phosphate in the treatment of patients with chronic lymphocytic leukemia

2021 ◽  
pp. 67-77
Author(s):  
G. G. Rodionov ◽  
I. I. Shantyr ◽  
V. B. Vasilyuk ◽  
E. A. Kolobova ◽  
E. V. Svetkina ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Quantitative Determination ◽  
Blood Plasma ◽  
B Cell ◽  
Individual Variability ◽  
Lymphocytic Leukemia ◽  
Pharmacokinetic Parameters ◽  
Cell Chronic Lymphocytic Leukemia ◽  
In Blood Plasma

Fludarabine is a purine antimetabolite with a pronounced immunosuppressive effect. The inhibitory effect of fludarabine depends on its concentration in blood plasma. In addition, the phenotypic characteristics of patients affect the pharmacokinetic and pharmacodynamic profile of the drug, which necessitates a personalized approach to the dosage regimen. The chromatography-mass spectrometric method for the quantitative determination of 2-fluorine in blood plasma was developed for studying the individual parameters of pharmacokinetics of the international non-proprietary name (INN) fludarabine in patients with B-cell chronic lymphocytic leukemia during the standard course. Such method for the quantitative determination of 2-fluorine in blood plasma was developed and validated in accordance with international requirements. Significant individual variability of the main pharmacokinetic parameters in patients with B-cell chronic lymphocytic leukemia with a single oral administration of the drug with INN fludarabine at a dose of 40 mg/m2 was established, so the coefficient of variability Cmax was 42 %, Tmax — 92 %, AUC0-t — 45 %, Kel — 23 %, T1/2 — 26 %. It should be noted that there is a high interindividual variability of fludarabine, for example, 24 hours after taking the study drug, the maximum and minimum plasma concentrations of the fludarabine metabolite 2-fluoro-ara-A in different in patients with B-cell chronic lymphocytic leukemia differed 9 times. Individual variability of pharmacokinetic parameters characterizing absorption (Cmax/AUC0-t) and total clearance of the active metabolite of fludarabine is statistically significantly associated with a combination of gender and anthropometric factors.

scholarly journals Quantitative Determination of Insulin Activity in Blood Plasma in Dogs by Rat Diaphragm Method

1957 ◽  
Vol 33 (4) ◽  
pp. 236-241 ◽  
Author(s):  
Yoshito KOBAYASHI ◽  
Shigeru OHASHI ◽  
Setsuya TAKEUCHI
Keyword(s):  
Quantitative Determination ◽  
Blood Plasma ◽  
Rat Diaphragm ◽  
Insulin Activity ◽  
In Blood Plasma

Quantitative Determination of Angipur Drug Substance in Blood Plasma by HPLC with Fluorescence Detection

2021 ◽  
Author(s):  
L. A. Smirnova ◽  
A. F. Ryabukha ◽  
O. K. Abramov ◽  
A. F. Kucheryavenko ◽  
A. A. Spasov ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Blood Plasma ◽  
Fluorescence Detection ◽  
Drug Substance ◽  
In Blood Plasma

Quantitative Determination of Krill Oil Composition by ATR-FTIR, NIR, and 31P NMR Spectroscopy

2020 ◽  
Author(s):  
Ashraf Ismail ◽  
Sanaz Molaye Moghaddam ◽  
Jean-Pierre MetabanzoulouSarya Aziz ◽  
Jacqueline Sedman ◽  
Mazen Bahadi
Keyword(s):  
Nmr Spectroscopy ◽  
Quantitative Determination ◽  
31P Nmr ◽  
31P Nmr Spectroscopy ◽  
Krill Oil ◽  
Oil Composition

Two SPRi biosensors for the determination of cathepsin S in blood plasma

Talanta ◽  
2021 ◽  
Vol 225 ◽  
pp. 121900
Author(s):  
Lukasz Oldak ◽  
Anna Sankiewicz ◽  
Beata Żelazowska-Rutkowska ◽  
Bogdan Cylwik ◽  
Zenon Lukaszewski ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Cathepsin S ◽  
In Blood Plasma
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