KNOWLEDGE ABOUT TUBERCULOSIS INFECTION IN WOMEN OF THE PERM REGION

In the conditions of an unfavorable epidemiological situation for tuberculosis in the Perm Region, there was a decrease in the coverage of preventive examinations for tuberculosis in 2020 due to restrictive measures related to the pandemic of a new coronavirus infection. One in five mothers of those who were not vaccinated with the BCG vaccine refused to carry it out. In order to study the knowledge about tuberculosis among women of the Perm Region, a survey was conducted of 108 residents of the Perm Region in 2019, 135 women in 2021 and 22 patients with pulmonary tuberculosis in 2021. The average age of the respondents was 40.2 years in 2019 and 37.8 years in 2021, among patients with pulmonary tuberculosis - 39.6 years. There is a fairly good knowledge about tuberculosis, about the need for an annual examination by Mantoux test methods, fluorography. Knowledge about the safety of BCG vaccination in the Perm Region among respondents increased from 2019 to 2021, as well as knowledge about the properties of the vaccine, allowed to reduce the negative opinion about it. From 2019 to 2021, there is a clear trend of increasing knowledge about the safety of the Mantoux sample. Despite the knowledge about fluorography, every fifth fluorography has not been performed for 2 or more years. The study allowed us to draw conclusions about the need to strengthen measures aimed at prevention, treatment and propaganda.

THE RISK OF DEVELOPING GYNECOLOGICAL CANCER IN WOMEN AFTER AN IN VITRO FERTILIZATION PROGRAM

This article presents reviews of literature sources on the issue of assessing the risk of developing gynecological cancer in women after an in vitro fertilization program. Infertility and infertile marriages have now become quite a big problem of modern medicine. Against the background of the unfavorable demographic situation in the Russian Federation, this problem is becoming quite urgent. The main way to solve this situation is assisted reproductive technologies, among which the most common is in vitro fertilization. The in vitro fertilization program is accompanied by a hormonal ovulation stimulation procedure to obtain a female germ cell capable of fertilization. Against the background of the active use of the in vitro fertilization procedure, many patients had concerns related to the risk of developing gynecological cancer after the IVF procedure, which is due to the use of hormonal drugs to stimulate the ovaries. Also of concern is the fact that certain types of cancer, including ovarian cancer, endometrial cancer and breast cancer, are hormone-dependent. In this regard, multiple large-scale studies were conducted, which showed that the risk of developing gynecological cancer is really increased in patients after the in vitro fertilization program. In particular, breast cancer in women after the in vitro fertilization program is more common by 10%, and in women without a history of pregnancy and over the age of 40, it is more common by 31%. The increased risk may be due to age-related vulnerability to the effects of hormones or higher doses of hormones during the IVF procedure. Ovarian cancer and endometrial cancer are also more common in patients after IVF. According to the research results, it is suggested that it is not the IVF procedure itself that causes the development of cancer, but excessive hormonal load of the body, which leads to the launch of carcinogenesis.

THE HEART DAMAGE AND ITS STRUCTURAL STATE FEATURES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION, COMPLICATED WITH ACUTE KIDNEY INJURY

Relevance. The role of hemodynamic changes in myocardial infarction complicated by acute kidney injury is interpreted in different ways. Aim. To evaluate the heart chambers and structures peculiarities in men under 60 years old with myocardial infarction complicated by acute kidney injury to improve prevention and outcomes. Material and methods. The study included men 19-60 years old with type I myocardial infarction. The patients were divided into two age-comparable groups: I - study group, with acute kidney injury - 25 patients; II - control, without it - 366 patients. A comparative assessment of the heart chambers and structures parameters in the first 48 hours (1) and at the end of the third week of the disease (2), their dynamics, also acute kidney injury development risk analysis (ANOVA) were performed. Results. The study group differed from the control group in smaller sizes of the left atrium2 (38.1±6.0 and 42.0±5.4 (mm), respectively; p=0.01), a higher frequency of the middle anterior (100 and 15.6%; p=0.02) and antero-septal (100 and 17.7; p=0.04) segments akinesia and the absence (0 and 81.5%; p=0.04) of tricuspid regurgitation. In the study group, there was a smaller increase in the ventricles size than in the control group (left: 0.6 and 1.7%, respectively; right: 15.3 and 33.6%) and a greater decrease in the atria size, compared in the control group (left: -1.8 and -25.3%; right: -25.3 and -0.1%) (p<0.0001). The risk markers of the acute kidney injury developing were the dimensions of the left atrium1˂34 mm, interventricular septum≥12.0 mm, end systolic1≥4.23 and diastolic1≥5.3 of the left ventricle, right ventricle1˂2.6; of the right atrium1≥4.7 (cm), the mass of the left ventricle1≥328.8 g. Conclusions. Men under 60 years old with acute kidney injury in myocardial infarction are characterized by lesions of the middle anterior and antero-septal segments, the absence of tricuspid regurgitation, and a smaller left atrium in the subacute period of the disease. The above of the heart chambers dimensions values should be used in the high-risk groups for the acute kidney injury development formation, as well as for prognostic modeling.

PROGRESSIVE ATHEROSCLEROTIC CORONARY ARTERIES IN PATIENTS WITH SEVERAL ISCHEMIC EVENTS IN ANAMNESIS

Вackground. Progressive atherosclerosis is accompanied by unfavorable clinical outcomes; study and understanding of this process is necessary to identify the appropriate risk groups. Purpose of the study to study the dynamics of atherosclerotic lesions of the coronary arteries in patients with several ischemic events in history. Patient Characterization and Research Methods. The present subanalysis included 51 patients with recurrent nonfatal myocardial infarction (MI) out of the initially included 100 patients with index MI. All 100 patients had a history of two or more ischemic coronary or cerebral events, which corresponds to the clinical signs of progressive atherosclerosis. The dynamics of the degree of coronary stenosis from the moment of index MI to repeated MI was assessed according to the data of selective coronary angiography. The statistical program Microsoft Office Excel 2019 was used. Results. All patients with recurrent myocardial infarction (51 people) had signs of progression of coronary artery stenosis: "mild" progression - 82.3%, "moderate" and "severe" - 15.6% and 2.1%, respectively. SYNTAX Score> 22.5 points was a predictor of one-year adverse outcomes: OR 6.349, CI (2.548-15.823). The results obtained make it possible to distinguish a group of patients with accelerated atherosclerosis syndrome in order to stratify the risk and optimally manage this complex category of patients.

OPTIMIZATION OF TREATMENT OF TUBAL-PERITONEAL INFERTILITY CAUSED BY CHRONIC SALPINGITIS

The outpatient stage of therapy is the primary and very responsible link in the introduction of patients with chronic forms of VZOMT, since this pathology has a significant impact on such indicators as perinatal, maternal morbidity and mortality. In addition, VZOMT directly affects the development of infertility, ectopic pregnancy, habitual miscarriage, as well as a decrease in the ovarian reserve after unsuccessful attempts of in vitro fertilization, surgical interventions on the appendages of the uterus. To preserve the reproductive function in patients with VZOMT, an important stage is the implementation of a number of therapeutic and rehabilitation measures. The problems of treatment and rehabilitation of patients with VZOMT undoubtedly remain relevant, since cases of relapses and chronization of inflammatory processes significantly worsen the prognosis for a woman's reproductive function. These problems are both social and economic. Taking into account the wide range of infectious agents of VZOMT, it is recommended to use a complex of antibacterial drugs that cover as many varieties of pathogenic and conditionally pathogenic flora as possible. Moreover, an important aspect of the treatment of inflammatory diseases of the female reproductive system is the use of different forms of drugs and ways of their administration. It is rational to combine oral or parenteral with intravaginal. This combination makes it possible to increase the effectiveness of treatment and contributes to the prevention of relapse of the disease. The inclusion of prednisolone – 21 phosphate in the therapy complex also contributes to increasing the effectiveness of therapy, since it creates favorable conditions for the vital activity of normal microflora and unfavorable conditions for conditionally pathogenic microflora. The results obtained in the study indicate a good clinical effectiveness of complex therapy with the inclusion of Elzhina in the treatment regimen for the treatment of fibrotic processes in the fallopian tubes. The use of a combined drug for intravaginal use containing ornidazole-500 mg, prednisolone-3 mg, econazole-150 mg, neomycin 65000ME (Elzhina drug) allows optimizing the management tactics of patients with tubal – peritoneal infertility caused by chronic salpingitis and increasing the fertility rates in this group of patients.

PHARMACEUTICAL MARKET OF CARDIOPLEGIC DRUGS AND FEATURES OF THEIR APPLICATION IN RUSSIA

Relevance. Surgical treatment of cardiovascular diseases with the use of artificial blood circulation is associated with the need to protect the myocardium. Various cardioplegic solutions are widely used in cardiac surgery to stop and protect the heart. Currently, a significant number of mixtures of drug solutions are used in "open" heart surgery. However, not all of them have been officially registered as cardioplegic solutions and not all have the appropriate indications in the instructions for medical use of the drug, which jeopardizes the safety and quality of medical care for patients. Goal. To study the pharmaceutical market of registered drugs for cardioplegia and to estimate the share of heart operations with the connection of artificial circulation performed without the use of officially registraited drugs for cardioplegia. Materials and methods. The following methods were used in the work: content analysis, statistical, marketing, graphic. The main information sources were: the State Register of Medicines; statistical indicators of surgical interventions in cardiac surgery, information on public procurement of medicines, instructions for the medical use of medicines, regulatory documents. Results. This study presents the results of a marketing analysis of the pharmaceutical market of drugs officially registered for cardioplegia. Three medicines have been registraited in Russia, which, in accordance with the instructions for use, can be used during surgical interventions in the quality of cardioplegic solutions. According to the ATC classification, all of them belong to the subgroup of the fifth level B05XA16 "Cardioplegic solutions". For the period 2018-2020. the volumes of purchases of cardioplegic solutions for the needs of medical organizations have been established and the volumes of drugs for surgical intervention in cardiac surgery during operations on the "open" heart have been determined. The comparison of morbidity rates and the estimated number of surgical interventions of the cardiac surgery service based on the data of public procurement of drugs for cardioplegia, revealed a discrepancy between the volumes of purchased cardioplegic solutions and the care provided. The data analysis shows that at least 23 thousand cardiac surgeries in Russia are performed annually without the use of registraited medicines for cardioplegia. Conclusion. When performing surgical interventions on an "open" heart with the connection of artificial blood circulation, it is necessary to use cardioplegic solutions that have an official indication in the instructions for medical use, in order to ensure the safety of patients and to perform medical interventions of appropriate quality.

POTENTIAL FOR IMPROVING THE QUALITY OF CANCER CARE

The quality of medical care is one of the leading problems of both foreign and domestic healthcare. The purpose of the study: to assess the potential of the quality of medical care of the oncological profile and to give recommendations for its improvement. Materials and methods. A study was conducted on the basis of the oncological service of the Ivanovo region. The research program included the use of expert, sociological and statistical methods. A survey of 120 doctors and an expert assessment of 410 cases of oncological care were conducted. A feature of the study was the use of an original method of integral assessment of the quality potential of oncological care. The potential for improving the quality of medical care was assessed in three components: infrastructure (personnel, logistics and drug support), procedural (compliance of the technology of assistance with standards and clinical recommendations), expert (quality of examination of the quality of medical care). Outcomes. It is established that the infrastructure component of the quality of medical care is of priority importance from the point of position of improvement (reserve 11,0%), in second place – the procedural component (9,0%), on the third – expert (5,0%). The survey showed that among medical personnel there is a high prevalence of adverse socio-hygienic factors: unsatisfactory housing conditions; a high percentage of unmarried personnel; a significant number of people suffering from chronic diseases; not observing the principles of a healthy lifestyle. Findings. The developed approach to improving the quality of medical care of the oncological profile, tested in the conditions of medical organizations of the Ivanovo region, will ensure targeted correction of factors associated with quality and a steady trend towards improving the quality of medical care. The set of proposals developed during the study was tested in an organizational experiment conducted on the basis of medical organizations that provide assistance to patients of the oncological profile of the Ivanovo region in 2019. According to the results of the implementation, a positive dynamic of the potential for the quality of medical care was obtained - from 91,7% to 98,5%.

PATIENT CULTURE AS A FACTOR IN ENSURING THE QUALITY OF MEDICAL CARE

The relevance of the study is due to the insufficient development of improving the structural component of the quality of medical care in terms of the cultural characteristics of the participants in their provision. The purpose of the study: to determine the contribution of the patient's culture factor to ensuring the quality of medical care of different profiles. The collection of material was carried out by the method of sociological survey of patients on the original questionnaires and the method of expert assessment of cases of medical care. The volume of the sample population formed by random selection amounted to 256 patients of dental profile, 320 therapeutic, 196 surgical (urological), 210 pediatric profile, respectively. An expert assessment of the quality of medical care was carried out according to the methodology that takes into account the implementation of its individual properties, for 984 cases of assistance. It is established that the quality of medical care is reliably influenced by the state of the cultural profile of patients. It was found that the assessment of the patient structural component of the quality of medical services without taking into account their profile was reduced to 40.6% relative to the maximum assessment, especially the characteristics of the sanological and information culture of the patient. The analysis of the role of patient cultural characteristics in the formation of the structural component of the quality of medical services showed the presence among them of characteristics that have a significant impact on the decline in the quality of services. The revealed differences in the value of the relative risk of the same patient cultural risk factor for reducing the quality of medical services in their different profiles substantiated the need to differentiate factors into high-risk and low-risk. The basis for managing the culture of patients should be measures to transform low gradations of cultural characteristics of patients into high ones, through medical information and education, socio-psychological counseling, patient education and the formation of behaviors focused on the preservation and promotion of health.

MANIFESTATIONS OF HEART INSUFFICIENCY IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION COMPLICATED WITH ACUTE KIDNEY DAMAGE

Relevance. Acute kidney injury in myocardial infarction worsens its prognosis, including due to the development of chronic heart failure. Moreover, most of the data was obtained for patients over 60 years old. Aim. To evaluate the features of the heart failure manifestations in men under 60 years old with myocardial infarction complicated by acute kidney injury to improve prevention and outcomes. Material and methods. The study included men 19-60 years old with type I myocardial infarction. The patients were divided into two age-comparable groups: I - study group, with acute kidney injury - 25 patients; II - control, without it - 486 patients. A comparative analysis of the heart failure main manifestations frequency in the first 48 hours (1) and at the end of the third week of the disease (2), their dynamics, analysis of their impact on the risk of chronic heart failure development in acute kidney injury (ANOVA) was performed. Results. The study group (4.0%) differed from the control (21.8%) in a lower frequency of acrocyanosis (p = 0.03) and liver enlargement (8.0 and 25.7%; respectively; p = 0.046) at the end of the eighth week diseases. The main risk markers of the chronic heart failure development in study group were: winter period of the year (absolute risk: 94.1%; relative - 3.76; p = 0.0003), respiratory infections 2-3 times a year (absolute risk: 81.8%; p = 0.003), left ventricular myocardial mass index1 ≥ 173.3 g/m2 (absolute risk: 100%; p = 0.008) and mean arterial pressure1 ≥ 120 mm Hg (absolute risk: 100%; relative - 1.88; p = 0.01). Conclusions. Men under 60 years old with acute kidney injury in myocardial infarction are characterized by a higher incidence of chronic heart failure. The listed above values of the different predictors should be used in the formation of the high-risk groups for the chronic heart failure in acute kidney injury development, as well as for prognostic modeling.

THE ROLE OF FAMILY IN PRESERVING OF HEALTH FROM THE VIEW OF THE YOUTH

The article is devoted to the analysis of views of the youth about health, factors contributing to health formation and the role of family in preserving of health. Methodology of work is a survey with electronic Google form. Attitudes and opinion of 430 people, citizens of Russia, mainly of the youngsters aged 18-24, have been studied. There was found that psychological and social components of health are the most important for young people, while the role of physical health in young age is underestimated. The majority of respondents (61,4%) defined healthy family as the one, where there are good sincere relationships between spouses and children. Half of the respondents (51,9%) marked the role of financial status of family in achievement of health. 34,4% of the respondents believe that in a healthy family parents devote much attention to self-development and education of their children. The majority of respondents (88,4%) realize that family is a key factor in formation of healthy behavior and healthy life style. Only half of respondents recognize the positive influence of family on their own health. The results of the study can be applied for development of regional and state programs in the field of public health and health promotion.