The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria

2006 ◽  
Vol 62 (12) ◽  
pp. 1021-1031 ◽  
Author(s):  
Rose McGready ◽  
Kasia Stepniewska ◽  
Niklas Lindegardh ◽  
Elizabeth A. Ashley ◽  
Yar La ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria

scholarly journals Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Falciparum Malaria

2011 ◽  
Vol 55 (12) ◽  
pp. 5500-5506 ◽  
Author(s):  
Marcus J. Rijken ◽  
Rose McGready ◽  
Aung Phae Phyo ◽  
Niklas Lindegardh ◽  
Joel Tarning ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Falciparum Malaria ◽  
Half Life ◽  
Drug Exposure ◽  
Venous Blood ◽  
Uncomplicated Falciparum Malaria ◽  
Fixed Dose ◽  
Pharmacokinetic Parameters ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling

ABSTRACTDihydroartemisinin-piperaquine is a fixed-dose artemisinin-based combination treatment. Some antimalarials have altered pharmacokinetics in pregnancy. Pregnant women in the 2nd or 3rd trimester and matched nonpregnant women with uncomplicated falciparum malaria were treated with a total of 6.4 mg/kg of body weight dihydroartemisinin and 51.2 mg/kg piperaquine once daily for 3 days. Venous blood samples were drawn at prespecified time points over 9 weeks. Plasma dihydroartemisinin and piperaquine concentrations were analyzed by liquid chromatography-mass spectrometry. Piperaquine and dihydroartemisinin pharmacokinetics were well described. There were no significant differences in total piperaquine exposure (P= 0.80) or drug exposure during the terminal elimination phase (72 h to infinity) (P= 0.64) between the two groups. The apparent volume of distribution of piperaquine was significantly smaller (602 liters/kg versus 877 liters/kg) in pregnant women than in nonpregnant women (P= 0.0057), and the terminal elimination half-life was significantly shorter (17.8 days versus 25.6 days;P= 0.0023). Dihydroartemisinin exposure after the first dose was significantly lower (844 h × ng/ml versus 1,220 h × ng/ml,P= 0.0021) in pregnant women, but there were no significant differences in total dihydroartemisinin exposure or maximum concentrations between the two groups. There were no significant differences in any pharmacokinetic parameters between the second and third trimester. These results obtained through noncompartmental analysis suggest that in the treatment of falciparum malaria, there are no clinically important differences in the pharmacokinetics of dihydroartemisinin or piperaquine between pregnant and nonpregnant women. However, a more detailed analysis using population pharmacokinetic modeling is needed to fully investigate the differences found for some of the pharmacokinetic parameters, such as the terminal half-life.

scholarly journals The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria

2009 ◽  
Vol 65 (8) ◽  
pp. 847-847
Author(s):  
Rose McGready ◽  
Kasia Stepniewska ◽  
Niklas Lindegardh ◽  
Elizabeth A. Ashley ◽  
Yar La ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria

Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria

2006 ◽  
Vol 62 (5) ◽  
pp. 367-371 ◽  
Author(s):  
R. McGready ◽  
K. Stepniewska ◽  
S. A. Ward ◽  
T. Cho ◽  
G. Gilveray ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria

A Phase IIA and IIB clinical trial of a quantified extract of Nauclea pobeguinii stem bark against uncomplicated falciparum malaria

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
L Pieters ◽  
K Mesia ◽  
L Tona ◽  
M Mampunza ◽  
N Ntamabyaliro ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Falciparum Malaria ◽  
Stem Bark ◽  
Uncomplicated Falciparum Malaria ◽  
Nauclea Pobeguinii

Patterns of Change in the Electrocardiogram after Halofantrine Treatment of Acute Uncomplicated Falciparum Malaria in Children

2000 ◽  
Vol 20 (4) ◽  
pp. 229-235
Author(s):  
A. Sowunmi ◽  
C.O. Falade ◽  
A.A. Adedeji ◽  
T.C. Happi ◽  
C.O. Sowunmi ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria

The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria

2003 ◽  
Vol 59 (7) ◽  
pp. 545-552 ◽  
Author(s):  
R. McGready ◽  
K. Stepniewska ◽  
M. D. Edstein ◽  
T. Cho ◽  
G. Gilveray ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Falciparum Malaria
Sign in / Sign up

Export Citation Format

Share Document