We investigate a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn–Hilliard type equation for the phase field variable, a reaction diffusion equation for the nutrient concentration and a Brinkman type equation for the velocity field. These PDEs are endowed with homogeneous Neumann boundary conditions for the phase field variable, the chemical potential and the nutrient as well as a “no-friction” boundary condition for the velocity. The control represents a medication by cytotoxic drugs and enters the phase field equation. The aim is to minimize a cost functional of standard tracking type that is designed to track the phase field variable during the time evolution and at some fixed final time. We show that our model satisfies the basics for calculus of variations and we present first-order and second-order conditions for local optimality. Moreover, we present a globality condition for critical controls and we show that the optimal control is unique on small time intervals.
Long-Time Dynamics and Optimal Control of a Diffuse Interface Model for Tumor Growth
