Anomalous Origin of a Coronary Artery from the Right Branchiocephalic Trunk Associated with Complex Congenital Heart Disease

AbstractAn anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital heart disease. Among the variants, an anomalous origin of the left anterior descending coronary artery from the pulmonary artery (ALADPA) is extremely rare. Here, we report a case of ALADPA in an adult that was treated with coronary artery bypass grafting using the left internal thoracic artery.

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Coronary anatomy in children with bicuspid aortic valves and associated congenital heart disease

Heart ◽

10.1136/heartjnl-2017-311178 ◽

2017 ◽

Vol 104 (5) ◽

pp. 385-393 ◽

Cited By ~ 8

Author(s):

Wilke M C Koenraadt ◽

Margot M Bartelings ◽

Regina Bökenkamp ◽

Adriana C Gittenberger-de Groot ◽

Marco C DeRuiter ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Coronary Arteries ◽

Congenital Heart ◽

Outflow Tract ◽

Complex Congenital Heart Disease ◽

Coronary Anatomy ◽

Perimembranous Ventricular Septal Defect ◽

Clinical Awareness

ObjectiveIn patients with bicuspid aortic valve (BAV), coronary anatomy is variable. High take-off coronary arteries have been described, but data are scarce, especially when associated with complex congenital heart disease (CHD). The purpose of this study was to describe coronary patterns in these patients.MethodsIn 84 postmortem heart specimens with BAV and associated CHD, position and height of the coronary ostia were studied and related to BAV morphology.ResultsHigh take-off right (RCA) and left coronary arteries (LCA) were observed in 23% and 37% of hearts, respectively, most frequently in hearts with hypoplastic left ventricle (HLV) and outflow tract anomalies. In HLV, high take-off was observed in 18/40 (45%) more frequently of LCA (n=14) than RCA (n=6). In hearts with aortic hypoplasia, 8/13 (62%) had high take-off LCA and 6/13 (46%) high take-off RCA. High take-off was seen 19 times in 22 specimens with perimembranous ventricular septal defect (RCA 8, LCA 11). High take-off was associated with type 1A BAV (raphe between right and left coronary leaflets), more outspoken for the RCA. Separate ostia of left anterior descending coronary artery and left circumflex coronary artery were seen in four hearts (5%), not related to specific BAV morphology.ConclusionHigh take-off coronary arteries, especially the LCA, occur more frequently in BAV with associated CHD than reported in normal hearts and isolated BAV. Outflow tract defects and HLV are associated with type 1A BAV and high take-off coronary arteries. Although it is unclear whether these findings in infants with detrimental outcome can be related to surviving adults, clinical awareness of variations in coronary anatomy is warranted.

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Ventricular septal defect with anomalous origin of the left descending coronary artery from the right sinus of Valsava and an intraseptal course

Asian Cardiovascular and Thoracic Annals ◽

10.1177/02184923211047054 ◽

2021 ◽

pp. 021849232110470

Author(s):

Guillaume Carles ◽

Marianne Peyre ◽

Alexia Dabadie ◽

Loïc Macé ◽

Marien Lenoir

Keyword(s):

Congenital Heart Disease ◽

Cardiac Surgery ◽

Heart Disease ◽

Coronary Artery ◽

Ventricular Septal Defect ◽

Congenital Heart ◽

Septal Defect ◽

The Right ◽

Coronary Compression ◽

Anatomic Result

Patients with anomalous aortic origin of the left anterior descending coronary artery (AAOCA) from the right sinus of Valsava, and associated with a trans-septal course, are recommended for surgery only when symptoms of ischemia are present. The transconal unroofing method is straightforward and provides good anatomic result. In absence of significant coronary compression, surgical management of the trans-septal coronary course is proposed if the patient is a candidate to cardiac surgery for another reason, such as congenital heart disease. We describe a transconal approach in a patient with a trans-septal coronary artery and a ventricular septal defect.

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Abstract 17204: Asymmetric Patterns of Cerebral Cortical Development in Fetuses With Complex Congenital Heart Disease

Circulation ◽

10.1161/circ.142.suppl_3.17204 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Yuanchiao Lu ◽

Kushal Kapse ◽

Nicole Andersen ◽

Catherine Lopez ◽

Jessica Quistorff ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Fetal Brain ◽

Fetal Mri ◽

Complex Congenital Heart Disease ◽

Single Shot ◽

Healthy Controls ◽

Hemispheric Asymmetries ◽

The Right

Introduction: Neurodevelopmental disabilities are common among infants with complex congenital heart disease (CHD). While hemispheric asymmetries in normal fetal brain size and shape have been reported, the effect of CHD on hemispheric development of the developing fetal brain remains unknown. Hypothesis: We hypothesized that emerging cerebral hemispheric asymmetries of the fetal CHD brain would differ compared to healthy controls using in vivo MRI tools. Methods: A total of 252 pregnant women were recruited (164 controls; 88 CHD fetuses), in which 328 fetal MRI scans were performed. Single shot fast spin echo T2-weighted images were acquired on a 1.5T GE MRI scanner. High-resolution 3D models of the fetal brain were reconstructed using slice-to-volume registration method for motion correction and Draw-EM algorithm for automatic segmentation. Volumetric analysis of brain tissues was conducted, and cortical folding measures of brain lobes were evaluated. Mixed effects regression was utilized to compare the brain features between right and left hemispheres for healthy controls and CHD fetuses. Results: The mean gestational age of all fetal MRI studies was 32.1±3.7 weeks (range: 24.0-39.4). For healthy fetuses, the volume of cortical gray matter was higher in the left hemisphere; however, this pattern was diminished in CHD fetuses. Gyrification indices were higher in the parietal and occipital lobes of the right hemisphere for controls, but not for CHD fetuses. Similarly, Gaussian curvature was higher in the right frontal lobe for controls only. Conversely, the surface area of the left occipital lobe was lower in CHD fetuses, but not in healthy fetuses. Conclusions: We report for the first time early disturbances in emerging hemispheric asymmetric patterns of the fetal brain in CHD compared to controls. The extent to which these lateralization differences reflect genetic, epigenetic and/or hemodynamic disturbances in CHD fetuses is under investigation.

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Case 5.20

Mayo Clinic Body MRI Case Review ◽

10.1093/med/9780199915705.003.0148 ◽

2014 ◽

pp. 280-281

Author(s):

Christine U. Lee ◽

James F. Glockner

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Complex Congenital Heart Disease ◽

History Of ◽

The Right ◽

Accessory Spleens

55-year-old woman with a history of complex congenital heart disease Axial postgadolinium 3D SPGR images (Figure 5.20.1) show a left-sided liver, right-sided stomach, and multiple small accessory spleens in the right upper quadrant. The IVC is absent, and the azygos and hemiazygos veins are prominent. Coronal postgadolinium 3D SPGR images (...

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Left main coronary artery compression by a dilated pulmonary artery after heart transplantation in an infant with complex congenital heart disease

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2012.12.014 ◽

2013 ◽

Vol 32 (4) ◽

pp. 470-472

Author(s):

Erin L. Albers ◽

David P. Bichell ◽

Debra A. Dodd

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Pulmonary Artery ◽

Heart Transplantation ◽

Congenital Heart ◽

Left Main Coronary Artery ◽

Complex Congenital Heart Disease ◽

Left Main

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Comorbidity as a mediator of depression in adults with congenital heart disease: A population-based cohort study

European Journal of Cardiovascular Nursing ◽

10.1177/1474515120923785 ◽

2020 ◽

pp. 147451512092378

Author(s):

Hsiao-Ling Yang ◽

Nien-Tzu Chang ◽

Jou-Kou Wang ◽

Chun-Wei Lu ◽

Yong-Chen Huang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Congenital Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Congenital Heart ◽

Adult Congenital Heart Disease ◽

Complex Congenital Heart Disease ◽

Chronic Obstructive ◽

Adult Congenital ◽

Artery Disease

Background The population of adults with congenital heart disease (CHD) has increased dramatically with a high prevalence of acquired cardiac and non-cardiac comorbidities. However, the relationship among congenital heart disease, physical comorbidities, and psychological health in this population is not well studied. Aims The purpose of this study was to investigate (a) the association between adult congenital heart disease and the occurrence of depression and (b) whether physical comorbidities mediated the association between congenital heart disease and the occurrence of depression. Methods This retrospective cohort study was followed from 1 January 2010–31 December 2013, based on the data from the National Health Insurance Research Database 2010 in Taiwan. We used mediation analysis in survival data to assess the mediated effect. The hazard ratios were adjusted by age, sex, area of residence, and estimated propensity scores. Results We recruited 2122 adult congenital heart disease patients and 8488 matched controls. Nearly half of patients diagnosed with simple congenital heart disease, 39.0% had complex congenital heart disease, and 11.2% had unclassified congenital heart disease. Adult congenital heart disease patients had a significantly higher risk of depression than matched controls (adjusted hazard ratio = 1.43 and 1.48, for all and complex congenital heart disease, respectively, p<0.05). Coronary artery disease and chronic obstructive pulmonary disease were the significant comorbidities mediating the relationship between adult congenital heart disease and depression, the proportions mediated by coronary artery disease or chronic obstructive pulmonary disease were 35.5% and 12.9%, respectively. Conclusions Helping patients to prevent psychological and physical acquired disease is imperative. Coronary artery disease is a potent mediator between congenital heart disease and depression, especially for patients with complex congenital heart disease.

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