Computational studies on class I ribonucleotide reductase: understanding the mechanisms of action and inhibition of a cornerstone enzyme for the treatment of cancer

2005 ◽  
Vol 35 (2) ◽  
pp. 125-135 ◽  
Author(s):  
Susana Pereira ◽  
Nuno M.F.S.A. Cerqueira ◽  
Pedro Alexandrino Fernandes ◽  
Maria João Ramos
Keyword(s):  
Ribonucleotide Reductase ◽  
Mechanisms Of Action ◽  
Class I ◽  
Computational Studies

Peroxo-Type Intermediates in Class I Ribonucleotide Reductase and Related Binuclear Non-Heme Iron Enzymes

2009 ◽  
Vol 131 (34) ◽  
pp. 12155-12171 ◽  
Author(s):  
Kasper P. Jensen ◽  
Caleb B. Bell, ◽  
Michael D. Clay ◽  
Edward I. Solomon
Keyword(s):  
Ribonucleotide Reductase ◽  
Heme Iron ◽  
Class I ◽  
Non Heme Iron ◽  
Iron Enzymes

scholarly journals Selenocysteine Substitution in a Class I Ribonucleotide Reductase

Biochemistry ◽  
2019 ◽  
Vol 58 (50) ◽  
pp. 5074-5084 ◽  
Author(s):  
Brandon L. Greene ◽  
JoAnne Stubbe ◽  
Daniel G. Nocera
Keyword(s):  
Ribonucleotide Reductase ◽  
Class I

scholarly journals Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor

Biochemistry ◽  
2018 ◽  
Vol 57 (18) ◽  
pp. 2679-2693 ◽  
Author(s):  
Hannah R. Rose ◽  
Manas K. Ghosh ◽  
Ailiena O. Maggiolo ◽  
Christopher J. Pollock ◽  
Elizabeth J. Blaesi ◽  
...  
Keyword(s):  
Ribonucleotide Reductase ◽  
Class I ◽  
Structural Basis ◽  
Radical Initiation ◽  
Flavobacterium Johnsoniae

scholarly journals Direct Measurement of the Radical Translocation Distance in the Class I Ribonucleotide Reductase fromChlamydia trachomatis

2015 ◽  
Vol 119 (43) ◽  
pp. 13777-13784 ◽  
Author(s):  
Jovan Livada ◽  
Ryan J. Martinie ◽  
Laura M. K. Dassama ◽  
Carsten Krebs ◽  
J. Martin Bollinger ◽  
...  
Keyword(s):  
Direct Measurement ◽  
Ribonucleotide Reductase ◽  
Class I

scholarly journals The Conserved Active Site Asparagine in Class I Ribonucleotide Reductase Is Essential for Catalysis

2001 ◽  
Vol 277 (8) ◽  
pp. 5749-5755 ◽  
Author(s):  
Alex Kasrayan ◽  
Annika L. Persson ◽  
Margareta Sahlin ◽  
Britt-Marie Sjöberg
Keyword(s):  
Ribonucleotide Reductase ◽  
Active Site ◽  
Class I

Radical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?

ChemInform ◽  
2003 ◽  
Vol 34 (32) ◽  
Author(s):  
JoAnne Stubbe ◽  
Daniel G. Nocera ◽  
Cyril S. Yee ◽  
Michelle C. Y. Chang
Keyword(s):  
Electron Transfer ◽  
Long Range ◽  
Ribonucleotide Reductase ◽  
Class I ◽  
Radical Initiation ◽  
Proton Coupled Electron Transfer
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