Malignant giant cell tumor of soft parts

2004 ◽  
Vol 33 (5) ◽  
pp. 295-299 ◽  
Author(s):  
Leslie G. Dodd ◽  
Nancy Major ◽  
Brian Brigman
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Malignant Giant Cell Tumor

Malignant Giant Cell Tumor of Bone

Orthopedics ◽  
1984 ◽  
Vol 7 (5) ◽  
pp. 909-913
Author(s):  
Michael G Rock ◽  
John W Beabout ◽  
Krishnan K Unni ◽  
Franklin H Sim
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Malignant Giant Cell Tumor

scholarly journals Malignant giant cell tumor of bone

2019 ◽  
Vol 03 (03) ◽  
pp. 83-86
Author(s):  
Emmanouil Neonakis ◽  
Georgia Antoniou ◽  
Ioannis K. Triantafyllopoulos
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Malignant Giant Cell Tumor

scholarly journals Giant Cell Tumor of Soft Parts: A Report of an Equine and a Feline Case

1975 ◽  
Vol 12 (5-6) ◽  
pp. 428-433 ◽  
Author(s):  
G. H. Ford ◽  
R. N. Empson ◽  
C. G. Plopper ◽  
P. H. Brown
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Giant Cells ◽  
Cell Tumor ◽  
Superficial Fascia ◽  
Femoral Canal ◽  
Malignant Giant Cell Tumor ◽  
Ultrastructural Characteristics ◽  
Characteristic Features ◽  
Multinucleate Giant Cells

Masses removed from the superficial fascia of the jugular groove of a 12-year-old Arabian mare and from the femoral canal of a 7 1/2-year-old female cat appeared to be counterparts of the human malignant giant cell tumor of soft parts, even recapitulating the clinical behavior of the respective subgroups. Histologically, both neoplasms contained the characteristic features of the malignant giant cell tumor of soft parts: large multinucleate giant cells, pleomorphic mononuclear giant cells, histiocytes, fibroblasts and fibrocytes that were sometimes sarcomatous, and foci of hemorrhage and necrosis. Ultrastructural characteristics of the giant cells suggest mesenchymal origin with osteoblastic or chondroblastic differentiation.

scholarly journals Malignancy in Giant Cell Tumor of Bone: A Review of the Literature

2019 ◽  
Vol 18 ◽  
pp. 153303381984000 ◽  
Author(s):  
Emanuela Palmerini ◽  
Piero Picci ◽  
Peter Reichardt ◽  
Gerald Downey
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cumulative Incidence ◽  
Cell Tumor ◽  
Secondary Malignancy ◽  
Primary Malignancy ◽  
Optimal Care ◽  
True Incidence ◽  
Small Series ◽  
Malignant Giant Cell Tumor

Background: Primary and recurrent giant cell tumor of bone is typically benign; however, rarely giant cell tumor of bone can undergo malignant transformation. Malignancy in giant cell tumor of bone may be primary (adjacent to benign giant cell tumor of bone at first diagnosis) or secondary (at the site of previously treated giant cell tumor of bone). Malignant giant cell tumor of bone has a poor prognosis; it is important to distinguish malignant from benign lesions to facilitate appropriate management. The true incidence of malignant giant cell tumor of bone is not known, probably owing to inaccurate diagnosis and inconsistent nomenclature. We have analyzed current data to provide a robust estimate of the incidence of malignancy in giant cell tumor of bone. Methods: A literature search was performed to source published reports of primary and secondary cases of malignant giant cell tumor of bone. Studies that reported a denominator were used to estimate the incidence of malignancy. Results: We identified 4 large series of patients with malignant giant cell tumor of bone that provided data on 2315 patients with giant cell tumor of bone. Across these studies, the cumulative incidence of malignancy was 4.0%; the cumulative incidence of primary malignancy was 1.6% compared with 2.4% for secondary malignancy. Our analyses confirmed that most malignant giant cell tumor of bone is secondary and occurs following radiation. In addition, data from 8 small series showed that 4.8% of patients with giant cell tumor of bone who received radiation therapy developed secondary malignancy. Conclusions: Malignant giant cell tumor of bone is rare, and its identification is hindered by a lack of clear diagnostic criteria. For optimal care of patients with giant cell tumor of bone, we recommend: comprehensive histologic sampling to ensure accurate diagnoses; watchful follow-up, particularly for patients treated with radiation; and timely treatment of local recurrence.

Malignant Giant Cell Tumor of Soft Parts Presenting as a Skin Tumor

1989 ◽  
Vol 11 (3) ◽  
pp. 197-201 ◽  
Author(s):  
Edwin Gould ◽  
Jorge Albores-Saavedra ◽  
Marti Rothe ◽  
Walid Mnaymneh ◽  
Sergio Menendez-Aponte
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Skin Tumor ◽  
Malignant Giant Cell Tumor

The importance of recognizing malignant giant cell tumor of soft parts

1978 ◽  
Vol 136 (1) ◽  
pp. 102-106 ◽  
Author(s):  
R.E. Robins ◽  
F.R.C. Johnstone ◽  
A. Worth ◽  
R.J. Fris
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Malignant Giant Cell Tumor
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