Can dimercaptosuccinic acid renal scintigraphy be used to assess global renal function?

Background/Aim. Ureteropelvic junction obstruction and vesicoureteral reflux are the most frequent entities identified on the basis of antenatal hydronephrosis. The aim of this study was to determine the incidence and pattern of abnormal renal scintigraphy findings in postnatal investigation of children with antenatal hydronephrosis. Methods. Twenty four infants (19 boys and five girls) presented with antenatal hydronephrosis and mild to moderate hydronephrosis on ultrasound in newborn period were referred for renal scintigraphy. Ten patients with vesicoureteral reflux documented on micturating cystoureterography underwent 99mTc-DMSA renal scintigraphy and 14 patients were subjected to 99mTc-DTPA scintigraphy. Results. Anteroposterior pelvic diameter on ultrasound ranged from 11 to 24 mm. Renal DMSA scans identified congenital scars in two boys with bilateral reflux of grade V and unilateral reflux of grade III. Relative kidney uptake (RKU) less than 40% was found in three, and poor kidney function (RKU less than 10%) in two patients. Significant obstruction was shown on DTPA diuretic renal scintigraphy in 6/14 patients. Some slowing in dranaige (T1/2 greater than 10 minutes) with no reduction in differential renal function was identified in three patients. Differential renal function less than 10% was obtained in one case. Conclusion. A high percent of abnormal renal scintigraphy findings was obtained. Renal scintigraphy was useful in determination of underlying cause of antenatally detected hydronephrosis.

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Evaluation of renal function after laparoscopic partial nephrectomy with renal scintigraphy using 99mtechnetium-mercaptoacetyltriglycine

International Journal of Urology ◽

10.1111/j.1442-2042.2006.01579.x ◽

2006 ◽

Vol 13 (11) ◽

pp. 1371-1374 ◽

Cited By ~ 23

Author(s):

KOBAYASHI YASUYUKI ◽

USUI YUKIO ◽

SHIMA MASANORI ◽

AKIO HOSHI ◽

MIYAKITA HIDESHI ◽

...

Keyword(s):

Renal Function ◽

Partial Nephrectomy ◽

Laparoscopic Partial Nephrectomy ◽

Renal Scintigraphy

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Does endoscopic sclerotherapy in filarial chyluria affect renal function and morphology? A prospective study using dimercaptosuccinic acid renal scan

Asian Journal of Urology ◽

10.1016/j.ajur.2019.03.003 ◽

2019 ◽

Vol 6 (4) ◽

pp. 359-363 ◽

Cited By ~ 1

Author(s):

Bimalesh Purkait ◽

Apul Goel ◽

Satyawati Deswal ◽

Monica Agrawal ◽

BhupendraPal Singh ◽

...

Keyword(s):

Renal Function ◽

Prospective Study ◽

Dimercaptosuccinic Acid ◽

Endoscopic Sclerotherapy ◽

Renal Scan ◽

A Prospective Study

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Renal Function Assessment Gap in Clinical Practice: An Awkward Truth

Kidney & Blood Pressure Research ◽

10.1159/000504649 ◽

2020 ◽

Vol 45 (2) ◽

pp. 166-179 ◽

Cited By ~ 2

Author(s):

Francesco Trevisani ◽

Federico Di Marco ◽

Umberto Capitanio ◽

Alessandro Larcher ◽

Arianna Bettiga ◽

...

Keyword(s):

Renal Function ◽

Clinical Practice ◽

Plasma Clearance ◽

Renal Scintigraphy ◽

Study Cohort ◽

Clinical Settings ◽

Gold Standard Method ◽

Disease Epidemiology ◽

Iohexol Plasma Clearance ◽

Gold Standards

Introduction: An accurate assessment of renal function is needed in the majority of clinical settings. Unfortunately, the most used estimated glomerular filtration rate (eGFR) formulas are affected by significant errors in comparison to gold standards methods of measured GFR (mGFR). Objective: The objective of the study is to determine the extent of the error of eGFR formulas compared to the mGFR in different specific clinical settings. Methods: A total retrospectively consecutive cohort of 1,320 patients (pts) enrolled in 2 different European Hospitals (Center 1: 470 pts; Center 2: 850 pts) was collected in order to compare the most common eGFR formulas used by physicians with the most widespread mGFR methods in daily clinical practice (Iohexol Plasma Clearance -Center 1 [mGFR-iox] and Renal Scintigraphy -Center 2 [mGFR-scnt]). The study cohort was composed by urological, oncological, and nephrological pts. The agreement between eGFR and mGFR was evaluated using bias (as median of difference), precision (as interquartile range of difference) accuracy (as P30), and total deviation index. Results: The most accurate eGFR formula in the comparison with gold standard method (Iohexol plasma clearance) in Center 1 was represented by s-creatinine and cystatin C combined Chronic Kidney Disease-Epidemiology Collaboration-cr-cy, even though the P30 is reduced (84%) under the threshold of 60 mL/min/1.73 m2. Similar results were found in Center 2, with a wider discrepancy between mGFR-scnt and eGFR formulas due to the minor accuracy of the nuclear tool in respect to the mGFR-iox. Conclusions: The loss of accuracy observed for the formulas at lower values of GFR suggests the mandatory use of gold standards methods as Iohexol Plasma Clearance to assess the correct status of renal function for critical cases. The center 2 showed lower levels of agreement between mGFR and eGFR suggesting that the errors are partially accounted for the Renal Scintigraphy technique too. In particular, we suggest the use of mGFR-iox in oncological urological and nephrological pts with an eGFR lower than 60 mL/min/1.73 m2.

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