Role of technetium-99m-ethylenedicysteine in the calculation of differential renal function: A comparison study with dimercaptosuccinic acid renal scintigraphy

Background/Aim. Ureteropelvic junction obstruction and vesicoureteral reflux are the most frequent entities identified on the basis of antenatal hydronephrosis. The aim of this study was to determine the incidence and pattern of abnormal renal scintigraphy findings in postnatal investigation of children with antenatal hydronephrosis. Methods. Twenty four infants (19 boys and five girls) presented with antenatal hydronephrosis and mild to moderate hydronephrosis on ultrasound in newborn period were referred for renal scintigraphy. Ten patients with vesicoureteral reflux documented on micturating cystoureterography underwent 99mTc-DMSA renal scintigraphy and 14 patients were subjected to 99mTc-DTPA scintigraphy. Results. Anteroposterior pelvic diameter on ultrasound ranged from 11 to 24 mm. Renal DMSA scans identified congenital scars in two boys with bilateral reflux of grade V and unilateral reflux of grade III. Relative kidney uptake (RKU) less than 40% was found in three, and poor kidney function (RKU less than 10%) in two patients. Significant obstruction was shown on DTPA diuretic renal scintigraphy in 6/14 patients. Some slowing in dranaige (T1/2 greater than 10 minutes) with no reduction in differential renal function was identified in three patients. Differential renal function less than 10% was obtained in one case. Conclusion. A high percent of abnormal renal scintigraphy findings was obtained. Renal scintigraphy was useful in determination of underlying cause of antenatally detected hydronephrosis.

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Assessment of various parameters in the estimation of differential renal function using technetium-99m mercaptoacetyltriglycine

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s002590050372 ◽

1999 ◽

Vol 26 (2) ◽

pp. 155-162 ◽

Cited By ~ 22

Author(s):

Mark F. Lythgoe ◽

Isky Gordon ◽

Zambia Khader ◽

Terry Smith ◽

Peter J. Anderson

Keyword(s):

Renal Function ◽

Technetium 99M ◽

Differential Renal Function

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Role of 99mTc-(V)DMSA in Detecting Tumor Cell Proliferation

Analytical Chemistry Insights ◽

10.4137/117739010700200001 ◽

2007 ◽

Vol 2 ◽

pp. 117739010700200 ◽

Cited By ~ 6

Author(s):

Fatma Al-Saeedi

Keyword(s):

Cell Proliferation ◽

Tumor Cell ◽

Tumor Cells ◽

Dimercaptosuccinic Acid ◽

Cell Detection ◽

Tumor Cell Proliferation ◽

Technetium 99M ◽

Tumor Cell Detection ◽

Technetium 99M Dimercaptosuccinic Acid

Pentavalent technetium-99m dimercaptosuccinic acid (99mTc-(V)DMSA) is a tumor-seeking agent which was introduced to evaluate, image, and manage many types of cancers. In this review, the beginning of, and the most recent applications of using this agent was appraised. The relation with tumor cell detection and proliferation was reported and several mechanisms of uptake of 99mTc-(V)DMSA in tumor cells are described.

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