Abstract
[EXSCINDED]
Abstract
Abstract
Background
Central pancreatectomy (CP) is an ideal surgery option for benign and low malignant potential lesions in the neck and body of pancreas. CP maintains pancreatic endocrine and exocrine function better than distal pancreatectomy and pancreaticoduodenectomy, but it has a higher risk of pancreatic fistula1. Up to now, CP reported by Dagradi and Serio2 is the standard procedure. But our four-year experience suggests CP with end-to-end anastomosis could reduce pancreatic fistula and other complication rates. The aim of the trial is to investigate whether the CP combined with end-to-end anastomosis reconstruction approach can reduce the fistula rate of patients with pancreatic neck and body benign and low malignant lesions compared with the conventional approach. We hypothesize that CP combined with end-to-end anastomosis could be an alternative procedure of conventional CP.Methods/design
The trial is a single center, randomized controlled trial with two parallel research group. The trial compares the possible advantages of CP combined with end-to-end anastomosis to conventional CP in robotic surgery. One hundred and seventy patients with pancreatic neck and body benign and low malignant lesions in Chinese People’s Liberation Army (PLA) General Hospital will be enrolled. The patients will be divided into two groups randomly. One group will choose CP with end-to-end anastomosis while the other group will use conventional CP. The primary endpoint will be postoperative pancreatic fistula (POPF) rate.Discussion
There is no randomized clinical trial to estimate the advantages of CP with end-to-end anastomosis reconstruction.
The CP with end-to-end anastomosis reconstruction in robotic surgery was first reported by Professor Liu in our department, and professional surgical techniques can reduce confounding factors and have high recruitment rate. For our research is a randomized clinical trial, we can provide high quality evidence on CP standard.
The effect of fibrinogen/thrombin-coated collagen patch (TachoSil®) application in pancreaticojejunostomy for prevention of pancreatic fistula after pancreatoduodenectomy: a randomized clinical trial
