Abstract
Objective: The aim of present study was to evaluate the efficacy and safety of fibrin sealant on knee function restoration following total knee replacement. Methods: PubMed, Web of Science, Cohrane library, and Embase were searched up to August 2021. All prospective randomized controlled trial involving fibrin sealant treatment for total knee replacement were included in this meta-analysis. Range of motion, total blood loss, blood transfusion rate, hemoglobulin reduction, hospital stay, and complication were calculated using RevMan 5.4 software.Results: Totally 23 randomized clinical trials involving 2267 patients (1136 patients for fibrin sealant group and 1131 patients for control group) were finally included. The results indicated that that the usage of fibrin sealant in total knee replacement can reduce the total blood loss [95% (-935.81, -351.70), P<0.0001], transfusion rate [95%CI (0.47, 0.90), P=0.01], hemoglobulin reduction [95%CI (-2.94, -0.74), P=0.001] and hospital stay [95%CI (-1.76, -0.42), P=0.001] without increasing the rate of complication [95%CI (-0.04, 0.02), P=0.42], but cannot increase the knee range of motion [95%CI (-1.17,9.29), P=0.13].Conclusion: The usage of fibrin sealant can effectively reduce the total blood loss, transfusion rate, hemoglobulin reduction and hospital stay without increasing the rate of complication, but cannot increase the knee range of motion