Shear wave elastography for liver fibrosis in chronic hepatitis B: Adapting the cut-offs to alanine aminotransferase levels improves accuracy

2018 ◽  
Vol 29 (2) ◽  
pp. 857-865 ◽  
Author(s):  
Jie Zeng ◽  
Jian Zheng ◽  
Jie-Yang Jin ◽  
Yong-Jiang Mao ◽  
Huan-Yi Guo ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Shear Wave ◽  
Chronic Hepatitis B ◽  
Alanine Aminotransferase ◽  
Shear Wave Elastography

A study of spleen shear-wave elastography in indirect prediction of liver fibrosis in patients with chronic hepatitis B

2020 ◽  
Vol 76 (1) ◽  
pp. 63-72
Author(s):  
Yi Zheng ◽  
Shujun Xia ◽  
Xinping Ren ◽  
Weiwei Zhan ◽  
Zhan Zheng ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Shear Wave ◽  
Chronic Hepatitis B ◽  
Characteristic Curve ◽  
Shear Wave Elastography ◽  
Final Diagnosis ◽  
Predicting Performance ◽  
Reference Index

PURPOSE: To evaluate the value of spleen shear-wave elastography (sound touch elastography [STE], sound touch quantification [STQ]) in indirect prediction of liver fibrosis in patients with chronic hepatitis B (CHB). METHODS: The Young’s modulus (kPa) of spleen STE, STQ and liver FibroScan were measured in 112 patients with CHB. The final diagnosis was according to histological results from liver biopsy based on Scheure G/S scoring system and liver FibroScan was considered as a reference index of prediction efficiency. Grouped by the stage of liver fibrosis, data were analyzed by Spearman correlation analysis, Mann-Whitney test and receiver operating characteristic curve (ROC). RESULTS: Spleen STE was positively correlated with the degree of liver fibrosis, but spleen STQ was not. STEmean and STEmax of spleen were statistically different between the groups categorized by S = 2, S = 3 and S = 4 (all p < 0.05), respectively. Spleen STEmean had the best predicting performance on staging liver fibrosis. The areas under the ROC (AUC) for spleen STEmean were 0.66 (95% confidence interval [CI], 0.56–0.76) for stage S = 2 or higher, 0.72 (95% CI, 0.60–0.83) for S = 3 or higher, 0.83 (95% CI, 0.74–0.92) for S = 4 (all P < 0.01). The differences between the AUC for spleen STEmean and liver FibroScan in liver fibrosis staging were not statistically significant when the groups categorized by S = 2 and S = 4 (P = 0.146 and P = 0.052). But when categorized by S = 3, the evaluating performance of liver FibroScan was better (P = 0.004). CONCLUSION: STEmean of spleen is applicable in indirect predicting fibrosis stage in patients with CHB.

Comparison of 2-D Shear Wave Elastography and Transient Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B

2017 ◽  
Vol 43 (8) ◽  
pp. 1563-1570 ◽  
Author(s):  
Jie Zeng ◽  
Jian Zheng ◽  
Zeping Huang ◽  
Shigao Chen ◽  
Jing Liu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Shear Wave ◽  
Chronic Hepatitis B ◽  
Transient Elastography ◽  
Shear Wave Elastography
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