Genes, cells and organs: recent developments in the molecular genetics of mammalian sex determination

1998 ◽  
Vol 9 (9) ◽  
pp. 683-687 ◽  
Author(s):  
Andy Greenfield
Keyword(s):  
Sex Determination ◽  
Molecular Genetics ◽  
Recent Developments

scholarly journals Extended Reproductive Roles of the fruitless Gene in Drosophila melanogaster Revealed by Behavioral Analysis of New fru Mutants

Genetics ◽  
1997 ◽  
Vol 147 (3) ◽  
pp. 1107-1130 ◽  
Author(s):  
Adriana Villella ◽  
Donald A Gailey ◽  
Barbra Berwald ◽  
Saiyou Ohshima ◽  
Phillip T Barnes ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Sex Determination ◽  
Molecular Genetics ◽  
Behavioral Analysis ◽  
Behavioral Phenotypes ◽  
New Mutations

The fruitless mutants fru3 and fru4 were assessed for sex-specific reproductive-behavioral phenotypes and compared to the previously reported fru mutants. Among the several behavioral anomalies exhibited by males expressing these relatively new mutations, some are unique. fru3 and fru4 males are less stimulated to court females than and fru1 and fru2. No courtship pulse song is generated by either fru3 or fru4 males, even though they perform brief wing extensions. fru3 and fru4 males display significantly less chaining behavior than do fru1 males. The hierarchy of courtship responses by fru males directed toward females vs. males, when presented with both sexes simultaneously, is that fru1 males perform vigorous and indiscriminant courtship directed at either sex; fru4 males are similarly indiscriminant, but courtship levels were lower than fru1; fru2 males prefer females; fru3 males show a courtship bias toward males. fru3 and fru4 males essentially lack the Muscle of Lawrence (MOL). On several reproductive criteria, there was no difference between fru-variant females and fru  +. The increases in phenotypic severity measured for the new mutants are discussed in the context of the emerging molecular genetics of fru and with regard to the gene's position within the sex-determination pathway.

Molecular genetics of sex determination

1994 ◽  
Vol 10 (8) ◽  
pp. 297-298
Author(s):  
Stephen L. Mathias
Keyword(s):  
Sex Determination ◽  
Molecular Genetics

Molecular genetics of hypospadias and cryptorchidism recent developments

2018 ◽  
Vol 95 (1) ◽  
pp. 122-131 ◽  
Author(s):  
Nicolas Kalfa ◽  
Laura Gaspari ◽  
Margot Ollivier ◽  
Pascal Philibert ◽  
Anne Bergougnoux ◽  
...  
Keyword(s):  
Molecular Genetics ◽  
Recent Developments

Psychiatry, Molecular Genetics and Ethics: The New Discoveries and the New Issues

1989 ◽  
Vol 23 (1) ◽  
pp. 67-72 ◽  
Author(s):  
John McGrath
Keyword(s):  
Genetic Engineering ◽  
Molecular Genetics ◽  
New Technologies ◽  
Ethical Issues ◽  
Germ Line ◽  
Active Role ◽  
Huntington's Chorea ◽  
Psychiatric Illnesses ◽  
Future Developments ◽  
Recent Developments

Recent developments in molecular genetics are examined with particular reference to psychiatry. the new technologies available have allowed significant advances in the understanding of certain illnesses such as familial Alzheimer's disease and Huntington's chorea, and will provide powerful tools to explore many other important psychiatric illnesses. the area of genetic counselling is already characterized by complex ethical issues. We can expect that as the new technologies provide the prospect of positive germ line genetic engineering, these ethical issues will become more complex. It is important that psychiatrists prepare themselves for these future developments and take an active role in leading the debate.

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