The treatment of internal anal sphincter achalasia with botulinum toxin

2001 ◽  
Vol 17 (7) ◽  
pp. 521-523 ◽  
Author(s):  
Antonio Messineo ◽  
Daniela Codrich ◽  
Margherita Monai ◽  
Stefano Martellossi ◽  
Alessandro Ventura
Keyword(s):  
Botulinum Toxin ◽  
Anal Sphincter ◽  
Internal Anal Sphincter ◽  
Internal Anal Sphincter Achalasia

scholarly journals Botulinum toxin injection for internal anal sphincter achalasia after pull-through surgery in Hirschsprung disease

Medicine ◽  
2019 ◽  
Vol 98 (45) ◽  
pp. e17855 ◽  
Author(s):  
Joong Kee Youn ◽  
Ji-Won Han ◽  
Chaeyoun Oh ◽  
So-Young Kim ◽  
Sung-Eun Jung ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Anal Sphincter ◽  
Internal Anal Sphincter ◽  
Botulinum Toxin Injection ◽  
Hirschsprung Disease ◽  
Internal Anal Sphincter Achalasia ◽  
Pull Through

Internal Anal Sphincter Achalasia in Children: Clinical Characteristics and Treatment with Clostridium botulinum Toxin

2003 ◽  
Vol 37 (3) ◽  
pp. 315-319 ◽  
Author(s):  
Paola Ciamarra ◽  
Samuel Nurko ◽  
Edward Barksdale ◽  
Steven Fishman ◽  
Carlo Di Lorenzo
Keyword(s):  
Botulinum Toxin ◽  
Anal Sphincter ◽  
Internal Anal Sphincter ◽  
Clostridium Botulinum ◽  
Clinical Characteristics ◽  
Internal Anal Sphincter Achalasia

EUS-Guided Botulinum Toxin Injection of the Internal Anal Sphincter in Anorectal Outlet Obstruction

2014 ◽  
Vol 109 (8) ◽  
pp. 1293-1294 ◽  
Author(s):  
Arvind J Trindade ◽  
Robert Hirten ◽  
Ronald E Greenberg ◽  
Divyesh V Sejpal
Keyword(s):  
Botulinum Toxin ◽  
Anal Sphincter ◽  
Internal Anal Sphincter ◽  
Botulinum Toxin Injection ◽  
Outlet Obstruction

Distribution of Interstitial Cells of Cajal in the Internal Anal Sphincter of Patients With Internal Anal Sphincter Achalasia and Hirschsprung Disease

2003 ◽  
Vol 127 (9) ◽  
pp. 1192-1195 ◽  
Author(s):  
Anna Piaseczna Piotrowska ◽  
Valeria Solari ◽  
Prem Puri
Keyword(s):  
Anal Sphincter ◽  
Internal Anal Sphincter ◽  
Interstitial Cells Of Cajal ◽  
Internal Sphincter ◽  
Smooth Muscles ◽  
Hirschsprung Disease ◽  
Interstitial Cells ◽  
Nerve Fibers ◽  
Internal Anal Sphincter Achalasia ◽  
Cells Of Cajal

Abstract Context.—Interstitial cells of Cajal (ICCs) are pacemaker cells in the smooth muscles of the gut. The internal anal sphincter (IAS) is the most caudal part of gastrointestinal tract. It has the important function of maintaining fecal continence. It has been proposed that ICCs in the IAS mediate the inhibitory innervation of the recto-anal reflexes. Objective.—To investigate the distribution of ICCs in the normal IAS and in the IAS of children diagnosed with internal anal sphincter achalasia (IASA) and Hirschsprung disease (HD). Methods.—At the time of IAS myectomy, specimens of the IAS were taken from 8 patients with IASA, 4 patients with HD, and 4 normal controls. All specimens were examined using anti–c-Kit and antiperipherin antibodies; immunolocalization was detected with light microscopy. Density of the ICCs was graded by computerized image analysis. Results.—There was strong peripherin immunoreactivity in the ganglia cells and nerve fibers in the normal IAS. The number of peripherin-positive nerve fibers was markedly reduced in the IAS in patients with IASA. In HD patients, there was lack of peripherin immunoreactivity in the IAS, but hypertrophic nerve trunks stained strongly. Many c-Kit–positive ICCs were present among the muscle fibers and between the muscle bundles in the normal IAS. In HD and IASA patients, ICCs were absent or markedly reduced. Conclusion.—Altered distribution of ICCs in the internal sphincter in IASA and HD may contribute to motility dysfunction in these patients.

Long-Term Clinical Outcome After Botulinum Toxin Injection in Children With Nonrelaxing Internal Anal Sphincter

2009 ◽  
Vol 104 (4) ◽  
pp. 976-983 ◽  
Author(s):  
Bruno P Chumpitazi ◽  
Steven J Fishman ◽  
Samuel Nurko
Keyword(s):  
Botulinum Toxin ◽  
Clinical Outcome ◽  
Anal Sphincter ◽  
Internal Anal Sphincter ◽  
Botulinum Toxin Injection

Mo1352 Manometric Evaluation of Endoscopic Ultrasound Guided Botulinum Toxin Injection Into the Internal Anal Sphincter in Patients With Anal Sphincter Dyssynergia

2014 ◽  
Vol 79 (5) ◽  
pp. AB404
Author(s):  
Kathryn R. Byrne ◽  
Sara Glapa ◽  
Abdul H. Khan ◽  
Young OH ◽  
Walter J. Hogan ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Anal Sphincter ◽  
Endoscopic Ultrasound ◽  
Internal Anal Sphincter ◽  
Botulinum Toxin Injection ◽  
Ultrasound Guided
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