Primary signet ring cell carcinoma of rectum: a rare entity with unusual presentation

2014 ◽  
Vol 30 (5) ◽  
pp. 709-710 ◽  
Author(s):  
Jitin Yadav ◽  
Sanjay Kumar Yadav ◽  
Kumar Gaurav ◽  
Aftab Ahmed ◽  
Kattamanchi Adithya Reddy ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unusual Presentation ◽  
Rare Entity ◽  
Signet Ring ◽  
Ring Cell

Painless Jaundice Leading to Rare Entity of Signet Ring Cell Carcinoma in Ampulla of Vater

2017 ◽  
Vol 112 ◽  
pp. S1593-S1594
Author(s):  
Sadat Iqbal ◽  
Ghulam Ilyas ◽  
Kamran Ilyas ◽  
Abu Hurairah ◽  
Richard Ferstenberg
Keyword(s):  
Cell Carcinoma ◽  
Ampulla Of Vater ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Rare Entity ◽  
Signet Ring ◽  
Painless Jaundice ◽  
Ring Cell

Primary signet ring cell carcinoma of colon-an unusual presentation

2000 ◽  
Vol 95 (9) ◽  
pp. 2527-2527
Author(s):  
Vijay Arya ◽  
Prag Gupta ◽  
Manish Sheth ◽  
Yashpal Arya ◽  
Afaf Abdu ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unusual Presentation ◽  
Signet Ring ◽  
Ring Cell ◽  
Carcinoma Of Colon

An Unusual Presentation of Gastric Signet Ring Cell Carcinoma: Lower Back Pain as the Primary Symptom

2017 ◽  
Vol 112 ◽  
pp. S1587-S1588
Author(s):  
Aulio Bustos ◽  
Vahe Shanazarian ◽  
Mohammed Al-Juboori ◽  
Priyanka Yerragorla ◽  
Ahmed Shady
Keyword(s):  
Back Pain ◽  
Cell Carcinoma ◽  
Lower Back Pain ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unusual Presentation ◽  
Lower Back ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary signet‐ring cell carcinoma of the lung in an HIV‐positive patient

2021 ◽  
Vol 12 (7) ◽  
pp. 1122-1125
Author(s):  
Alberto Testori ◽  
Gianluca Perroni ◽  
Camilla De Carlo ◽  
Alessandro Crepaldi ◽  
Marco Alloisio ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Positive Patient ◽  
Hiv Positive ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents

2021 ◽  
Vol 28 (1) ◽  
pp. 918-927
Author(s):  
Lei-Chi Wang ◽  
Tai-Chi Lin ◽  
Yi-Chen Yeh ◽  
Hsiang-Ling Ho ◽  
Chieh-Chih Tsai ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Tumor Tissue ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Next Generation ◽  
Signet Ring ◽  
Ring Cell ◽  
Generation Sequencing ◽  
E Cadherin

Primary signet ring cell/histiocytoid carcinoma of the eyelid is a rare ocular malignancy and its diagnosis is often delayed. This neoplasm presents as an insidious, diffusely infiltrative mass in the periocular area that later infiltrates the orbit. An exenteration is usually indicated; however, nearly one-third of patients develop local recurrence or metastasis. Morphologically, it resembles signet ring cell carcinoma of the stomach and breast, raising the possibility of mutations in CDH1, the gene encoding E-cadherin. To determine whether primary signet ring cell/histiocytoid carcinoma harbors the CDH1 mutation or other actionable mutations, we analyzed the tumor tissue via next-generation sequencing. We identified only one case of primary signet ring cell carcinoma of the eyelid with adequate DNA quality for sequencing from the pathological archive during the period 2000 to 2020. A comprehensive evaluation including histopathology, immunohistochemistry, and next-generation sequencing assay was performed on tumor tissue. Immunohistochemically, the tumor exhibited E-cadherin membranous staining with the aberrant cytoplasmic staining of β-catenin. Using next-generation sequencing, we demonstrated the mutation in the CDH1 gene. In addition, other clinically actionable mutations including ERBB2 and PIK3CA were also detected. The alterations in other actionable genes indicate a need for larger studies to evaluate the pathogenesis and potential therapies for primary signet ring cell/histiocytoid carcinoma of the eyelid.

Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma

2021 ◽  
pp. 106689692199418
Author(s):  
John D. Coyne ◽  
S. Thampy
Keyword(s):  
Proton Pump Inhibitor ◽  
Cell Carcinoma ◽  
Parietal Cell ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Fundic Gland ◽  
Fundic Gland Polyp ◽  
Signet Ring ◽  
Ring Cell

Pseudo-signet ring parietal cell vacuolation has been described as a mimic of invasive signet ring cell carcinoma. Moreover, signet ring cell carcinoma has been described in a fundic gland polyp. This case demonstrates parietal cell vacuolation in a fundic gland polyp in a patient on a long-term proton pump inhibitor.

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