Comparison of the pathological response of the mesorectal positive nodes between short-course chemoradiotherapy with delayed surgery and long-course chemoradiotherapy in patients with rectal cancer

2015 ◽  
Vol 30 (10) ◽  
pp. 1339-1347 ◽  
Author(s):  
Naohito Beppu ◽  
Masayoshi Kobayashi ◽  
Nagahide Matsubara ◽  
Masashi Noda ◽  
Tomoki Yamano ◽  
...  
2015 ◽  
Vol 16 (14) ◽  
pp. 5755-5762 ◽  
Author(s):  
Shi-Xin Liu ◽  
Zhi-Rui Zhou ◽  
Ling-Xiao Chen ◽  
Yong-Jing Yang ◽  
Zhi-De Hu ◽  
...  

2016 ◽  
Vol 15 (3) ◽  
pp. e93-e99 ◽  
Author(s):  
Lisette M. Wiltink ◽  
Remi A. Nout ◽  
Jochem R.N. van der Voort van Zyp ◽  
Heleen M. Ceha ◽  
Marta Fiocco ◽  
...  

2012 ◽  
Vol 99 (4) ◽  
pp. 577-583 ◽  
Author(s):  
D. Pettersson ◽  
T. Holm ◽  
H. Iversen ◽  
L. Blomqvist ◽  
B. Glimelius ◽  
...  

2017 ◽  
Vol 18 (6) ◽  
pp. e293
Author(s):  
Tomohiro Kurokawa ◽  
Giichiro Tsurita ◽  
Tetsuya Tanimoto ◽  
Norio Kanzaki ◽  
Tomozo Ejiri

2016 ◽  
pp. 408-443
Author(s):  
Regina Beets-Tan ◽  
Bengt Glimelius ◽  
Lars Påhlman

In rectal cancer treatment, surgery is most important. Dissection outside the mesorectal fascia, total mesorectal excision is required for cure in most cases; a local procedure is possible in the earliest tumours. Appropriate staging is required prior to treatment decision to stratify patients into risk groups. In early tumours surgery alone is sufficient whereas in intermediate cancers local recurrence rates are too high and preoperative radiotherapy is indicated. A short-course schedule is convenient, low toxic, although some prefer long-course chemoradiotherapy. The addition of a fluoropyrimidine enhances the radiotherapy. In locally advanced tumours preoperative chemoradiotherapy is required. The value of adjuvant chemotherapy in rectal cancer is controversial, particularly if preoperative chemoradiotherapy was used. Palliative chemotherapy prolongs life and improves well-being in patients with metastatic disease. Targeted drugs further improves the results to some extent. In some patients, chemotherapy may convert non-readily resectable metastases to resectable, and result in long-term cure.


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