Elevated blood urea nitrogen-to-creatinine ratio increased the risk of hospitalization and all-cause death in patients with chronic heart failure

2009 ◽  
Vol 98 (8) ◽  
pp. 487-492 ◽  
Author(s):  
Hung-Ju Lin ◽  
Chia-Lun Chao ◽  
Kuo-Liong Chien ◽  
Yi-Lwun Ho ◽  
Chii-Ming Lee ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Blood Urea Nitrogen ◽  
Creatinine Ratio ◽  
Elevated Blood ◽  
Urea Nitrogen ◽  
Elevated Blood Urea Nitrogen

scholarly journals The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio

2016 ◽  
Vol 215 ◽  
pp. 521-526 ◽  
Author(s):  
Meredith A. Brisco ◽  
Michael R. Zile ◽  
Jozine M. ter Maaten ◽  
Jennifer S. Hanberg ◽  
F. Perry Wilson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Urea Nitrogen ◽  
Creatinine Ratio ◽  
Elevated Blood ◽  
Urea Nitrogen ◽  
Risk Of Death ◽  
Elevated Blood Urea Nitrogen

Abstract 12975: Cardiac I-123 Metaiodobenzylguanidine Imaging Predicts the Risk of Cardiac Death in Patients With Chronic Heart Failure, Irrespective of Blood Urea Nitrogen to Creatinine Ratio: A Long-Term Follow Up Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Hideyuki Hakui ◽  
Takahisa Yamada ◽  
Takashi Motrita ◽  
Yoshio Furukawa ◽  
Shunsuke Tamaki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Blood Urea Nitrogen ◽  
Cardiac Death ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
Mibg Imaging ◽  
Creatinine Ratio ◽  
Urea Nitrogen

Background: Cardiac I-123 metaiodobenzylguanidine (MIBG) imaging, which reflects cardiac sympathetic activity, provides prognostic information in patients with chronic heart failure (CHF). On the other hand, elevated blood urea nitrogen to creatinine ratio (BUN/Cr), a surrogate for renal neurohumoral activation, is associated with poor outcome in patients with heart failure. However, there is no information available on the prognostic value of cardiac MIBG imaging in patients with CHF, relating to BUN/Cr. Methods: We studied 109 CHF outpatients (NYHA class:2.1±0.6, ischemic origin:52%) with left ventricular ejection fraction <40% (30±8%) in our prospective cohort study. At the enrollment, we measured serum level of BUN and Cr, and performed cardiac MIBG scintigraphy. Elevated BUN/Cr was defined as >20. The cardiac MIBG washout rate (WR) was calculated from the chest anterior view images obtained at 20 and 200 min after isotope injection. Abnormal WR was defined as >27%. Results: Forty patients had elevated BUN/Cr, and 55 patients had abnormal WR. During a follow up period of 7.5±4.2 yrs, 36 of 109 patients had cardiac death. At multivariate Cox analysis, WR was significantly independently associated with cardiac death in group with both elevated BUN/Cr (p=0.02) and normal BUN/Cr (p=0.004). Kaplan-Meier analysis showed that patients with abnormal WR had a higher risk of cardiac death than those with normal WR, in group with both elevated BUN/Cr (48%[11/23] vs 6%[1/17], p=0.02, adjusted hazard ratio 11.8[95%CI 1.5-92.2]) and normal BUN/Cr (55%[18/33] vs 17%[6/36], p=0.001, adjusted hazard ratio 4.6[95%CI 1.8-11.6]). Conclusion: The cardiac MIBG imaging could predict the risk of cardiac death in CHF, irrespective of BUN/Cr.

622 Blood urea nitrogen — an important prognostic marker in patients with chronic heart failure

2006 ◽  
Vol 5 (1) ◽  
pp. 145-146
Author(s):  
M ROIK ◽  
M STARCZEWSKA ◽  
S STAWICKI ◽  
Z HUCZEK ◽  
J KOCHANOWSKI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Prognostic Marker ◽  
Blood Urea Nitrogen ◽  
Urea Nitrogen
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