scholarly journals The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio

2016 ◽  
Vol 215 ◽  
pp. 521-526 ◽  
Author(s):  
Meredith A. Brisco ◽  
Michael R. Zile ◽  
Jozine M. ter Maaten ◽  
Jennifer S. Hanberg ◽  
F. Perry Wilson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Urea Nitrogen ◽  
Creatinine Ratio ◽  
Elevated Blood ◽  
Urea Nitrogen ◽  
Risk Of Death ◽  
Elevated Blood Urea Nitrogen

scholarly journals Defective ADP-Induced Platelet Factor 3 Activation in Uremia

Blood ◽  
1967 ◽  
Vol 30 (3) ◽  
pp. 331-340 ◽  
Author(s):  
HERBERT I. HOROWITZ ◽  
BURTON D. COHEN ◽  
PABLO MARTINEZ ◽  
MITSU F. PAPAYOANOU
Keyword(s):  
Blood Urea Nitrogen ◽  
Platelet Rich Plasma ◽  
Elevated Blood ◽  
Platelet Factor ◽  
Urea Nitrogen ◽  
Guanidinosuccinic Acid ◽  
Elevated Blood Urea Nitrogen ◽  
Abnormal Results

Abstract A test for platelet thromboplastic function measuring the activation of platelet factor 3 on incubation of ADP with citrated platelet-rich plasma has been standardized in terms of ADP and platelet concentrations, and amount of agitation, to give sensitive and reproducible results. Abnormal results have been found in patients with elevated blood urea nitrogen; the abnormality is due to a plasma inhibitor and is reversible on the addition of small amounts of calcium. Guanidinosuccinic acid, a newly described metabolite found in the urine of patients with azotemia, also inhibits ADP-induced platelet factor 3 activation. The properties of guanidinosuccinic acid and the uremic inhibitor so far studied suggest that they may be identical.

Sign in / Sign up

Export Citation Format

Share Document