Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition

2001 ◽  
Vol 96 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Caroline M�tais ◽  
Cesario Bianchi ◽  
Jianyi Li ◽  
Michael Simons ◽  
Jian Li ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia ◽  
Cox 2

scholarly journals Uncovering the Protective Mechanism of the Volatile Oil of Acorus tatarinowii against Acute Myocardial Ischemia Injury Using Network Pharmacology and Experimental Validation

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Zhen-Zhong Zang ◽  
Li-Mei Chen ◽  
Yuan Liu ◽  
Yong-Mei Guan ◽  
Qing Du ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Signaling Pathways ◽  
Animal Experiments ◽  
Volatile Oil ◽  
Acute Myocardial Ischemia ◽  
Network Pharmacology ◽  
Therapeutic Effects ◽  
Western Blots ◽  
Acorus Tatarinowii ◽  
Cox 2

Acorus tatarinowii is a traditional aromatic resuscitation drug that can be clinically used to prevent cardiovascular diseases. The volatile oil of Acorus tatarinowii (VOA) possesses important medicinal properties, including protection against acute myocardial ischemia (MI) injury. However, the pharmacodynamic material basis and molecular mechanisms underlying this protective effect remain unclear. Using network pharmacology and animal experiments, we studied the mechanisms and pathways implicated in the activity of VOA against acute MI injury. First, VOA was extracted from three batches of Acorus tatarinowii using steam distillation, and then, its chemical composition was determined by GC-MS. Next, the components-targets and protein-protein interaction networks were constructed using systematic network pharmacology. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were also conducted in order to predict the possible pharmacodynamic mechanisms. Furthermore, animal experiments including ELISAs, histological examinations, and Western blots were performed in order to validate the pharmacological effects of VOA. In total, 33 chemical components were identified in VOA, and ß-asarone was found to be the most abundant component. Based on network pharmacology analysis, the therapeutic effects of VOA against myocardial ischemia might be mediated by signaling pathways involving COX-2, PPAR-α, VEGF, and cAMP. Overall, the obtained results indicate that VOA alleviates the pathological manifestations of isoproterenol-hydrochloride-induced myocardial ischemia in rats, including the decreased SOD (superoxide dismutase) content and increased LDH (lactic dehydrogenase) content. Moreover, the anti-MI effect of VOA might be attributed to the downregulation of the COX-2 protein that inhibits apoptosis, the upregulation of the PPAR-α protein that regulates energy metabolism, and the activation of VEGF and cAMP signaling pathways.

Heparin from Intestine and Lung Source Administered in Large Dose to Dogs with Acute Myocardial Ischemia

1978 ◽  
Vol 40 (02) ◽  
pp. 407-417
Author(s):  
Michael J Saliba ◽  
Richard J Pavalec
Keyword(s):  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Adenosine Triphosphate ◽  
Intestinal Mucosa ◽  
Large Dose ◽  
Acute Myocardial Ischemia ◽  
Ischemic Myocardium ◽  
Atp Levels ◽  
Initial Control ◽  
The Difference

SummaryIntestinal mucosa heparin (IMH) and beef lung heparin (BLH) were infused into dogs subjected to myocardial ischemia by intermittent coronary artery occlusions. The IMH was from a mixture of beef, sheep, and pig intestinal mucosa. Initial control occlusion and recovery was followed by a second occlusion with 60,000 units of IMH or BLH added. Electrocardiographic S-T segment elevations (ST) were measured acutely. There were no significant differences in ST in non-ischemic myocardium before occlusions or with occlusions. In ischemic myocardium, IMH significantly lowered control ST 84% in amount (t = 6.1 p <0.00005), and 76% in number (t = 11.6 p <0.00001). BLH lowered control ST a significant, lesser, 36% in amount (t = 3.6 p <0.008), and 35% in number (t = 3.2 p <0.01). The difference between IMH and BLH in ischemic myocardium was a significant 48% in amount (t = 4.0 p <0.0007), and 41% in number (t = 2.0 p <0.06). Myocardial adenosine triphosphate (ATP) levels were assayed after 90 min. ATP levels were 31% higher in both ischemic and non-ischemic myocardium in IMH-treated dogs than in BLH- treated. It was concluded that IMH and BLH are functionally different, and IMH was significantly more effective.

In Vivo MRI Visualization of Acute Myocardial Ischemia and Reperfusion in Ferrets by the Persistent Action of the Contrast Agent Gd(BME-DTTA)

Circulation ◽  
1995 ◽  
Vol 92 (12) ◽  
pp. 3549-3559 ◽  
Author(s):  
Tamás Simor ◽  
Wen-Jang Chu ◽  
Lynne Johnson ◽  
Andras Safranko ◽  
Mark Doyle ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Contrast Agent ◽  
Acute Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion

Stimulation of lymphatic drainage of the heart by propranolol, heparin, and rheogluman in acute myocardial ischemia

1990 ◽  
Vol 110 (5) ◽  
pp. 1465-1467
Author(s):  
Ya. D. Mamedov ◽  
Z. D. Ismailova ◽  
G. Sh. Garaev ◽  
Z. D. Ismailova
Keyword(s):  
Myocardial Ischemia ◽  
Lymphatic Drainage ◽  
Acute Myocardial Ischemia ◽  
Stimulation Of

Pneumopericardium Mimicking Acute Myocardial Ischemia After Laparoscopic Cholecystectomy

1999 ◽  
Vol 92 (10) ◽  
pp. 1002-1004 ◽  
Author(s):  
JASON BEAVER ◽  
DAVID SAFRAN
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia

scholarly journals Image-based modeling of acute myocardial ischemia using experimentally derived ischemic zone source representations

2018 ◽  
Vol 51 (4) ◽  
pp. 725-733 ◽  
Author(s):  
B.M. Burton ◽  
K.K. Aras ◽  
W.W. Good ◽  
J.D. Tate ◽  
B. Zenger ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia ◽  
Image Based Modeling

The determination of myocardial viability using Gd-DTPA in a canine model of acute myocardial ischemia and reperfusion

1996 ◽  
Vol 36 (5) ◽  
pp. 684-693 ◽  
Author(s):  
Raoul S. Pereira ◽  
Frank S. Prato ◽  
Gerald Wisenberg ◽  
Jane Sykes
Keyword(s):  
Myocardial Ischemia ◽  
Myocardial Viability ◽  
Canine Model ◽  
Acute Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion

Detection of Acute Myocardial Ischemia During Percutaneous Transluminal Coronary Angioplasty by Endocardial Acceleration

2004 ◽  
Vol 27 (5) ◽  
pp. 621-625 ◽  
Author(s):  
HEINZ P. THERES ◽  
DANIEL R. KAISER ◽  
SHANNON D. NELSON ◽  
MARTIN GLOS ◽  
THOMAS LEUTHOLD ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Coronary Angioplasty ◽  
Percutaneous Transluminal Coronary Angioplasty ◽  
Acute Myocardial Ischemia ◽  
Transluminal Coronary Angioplasty ◽  
Percutaneous Transluminal
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