Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides

2010 ◽  
Vol 302 (9) ◽  
pp. 653-656 ◽  
Author(s):  
Jakob Mutanu Jungersted ◽  
Julie K. Høgh ◽  
Lars I. Hellgren ◽  
Gregor B. E. Jemec ◽  
Tove Agner
Keyword(s):  
Stratum Corneum ◽  
Skin Barrier

Changes in corneocyte element concentrations occur in skin inner stratum corneum

1990 ◽  
Vol 48 (2) ◽  
pp. 146-147
Author(s):  
R. R. Warner
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Element Concentration ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Brick Wall ◽  
Inorganic Elements ◽  
Dry Skin ◽  
Skin Biopsies ◽  
Intercellular Lipid

Keratinocytes undergo maturation during their transit through the viable layers of skin, and then abruptly transform into flattened, anuclear corneocytes that constitute the cellular component of the skin barrier, the stratum corneum (SC). The SC is generally considered to be homogeneous in its structure and barrier properties, and is often shown schematically as a featureless brick wall, the “bricks” being the corneocytes, the “mortar” being intercellular lipid. Previously we showed the outer SC was not homogeneous in its composition, but contained steep gradients of the physiological inorganic elements Na, K and Cl, likely originating from sweat salts. Here we show the innermost corneocytes in human skin are also heterogeneous in composition, undergoing systematic changes in intracellular element concentration during transit into the interior of the SC.Human skin biopsies were taken from the lower leg of individuals with both “good” and “dry” skin and plunge-frozen in a stirred, cooled isopentane/propane mixture.

Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers

2021 ◽  
Vol 32 (4) ◽  
pp. 589-593
Author(s):  
Sylvia Anggraeni ◽  
Menul Ayu Umborowati ◽  
Damayanti Damayanti ◽  
Anang Endaryanto ◽  
Cita Rosita Sigit Prakoeswa
Keyword(s):  
Clinical Trial ◽  
Contact Dermatitis ◽  
Stratum Corneum ◽  
Skin Barrier ◽  
Centella Asiatica ◽  
Transepidermal Water Loss ◽  
Double Blind ◽  
Stratum Corneum Hydration ◽  
Double Blind Clinical Trial

Abstract Objectives Batik dyes contain irritant chemicals that increase the risk of skin barrier disruption. This study aims to determine the effect of Centella asiatica and ceramide in transepidermal water loss (TEWL), hydration of the stratum corneum and skin acidity (pH). Methods This was a double blind clinical trial of 30 Indonesian batik workers who suffered from skin dryness, but had no clinical manifestation of contact dermatitis. Subjects were given cream containing C. asiatica or ceramide that formulated and randomly labeled by manufacturer (PT Paragon Technology and Innovation). Both subjects and researchers were blinded to the type of the cream. Cream was applied to the hands and arms twice a day. Biological function of the skin (TEWL, stratum corneum hydration level, and skin acidity) was examined by Cutometer dual MP-580. Baseline was recorded in the first examination, followed by second and third examinations at two and four weeks after treatment. Results After four weeks treatment, there were significant improvement of C. asiatica application in evaluation of corneometer palmar (p=0.007; CI 95%), corneometer dorsum (p=0.001; CI 95%), and skin acidity dorsum (p=0.017; CI 95%). Ceramide application also gave significant improvement of corneometer palmar (0.038; CI 95%), skin acidity palmar (p=0.001; CI 95%), TEWL dorsum (p=0.023; CI 95%), corneometer dorsum (p=0.002; CI 95%) and skin acidity dorsum (p=0.011; CI 95%). There were no significant differences of C. asiatica effectiveness compared to ceramide in skin barrier improvement. Conclusions C. asiatica and ceramide can improve skin barrier hydration in order to prevent the risk of contact dermatitis in batik workers.

Beneficial effects of oral supplementation with ferulic acid, a plant phenolic compound, on the human skin barrier in healthy men

2021 ◽  
pp. 1-7
Author(s):  
Atsushi Suzuki ◽  
Tomoko Nomura ◽  
Hiroko Jokura ◽  
Naoya Kitamura ◽  
Akihiko Fujii ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Stratum Corneum ◽  
Water Loss ◽  
Nervous Activity ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Sympathetic Nervous Activity ◽  
Healthy Men ◽  
Stratum Corneum Hydration ◽  
Sympathetic Nervous

Abstract. Ferulic acid (FA) is a phytochemical compound with various physiologic functions. To clarify the effect of FA intake on skin barrier function (SBF), we conducted a placebo-controlled double-blind pilot trial. Sixteen healthy subjects were divided into 2 groups (n = 8) and ingested capsules containing either FA (200 mg) or placebo daily for 2 weeks. Two measures of SBF, transepidermal water loss and stratum corneum hydration, were assessed before and 2 weeks after the start of the study. Autonomic nervous activity, which is suggested to be related to SBF, was also measured. Compared with the values obtained before the start of the study, FA intake significantly reduced transepidermal water loss (from 6.1 ± 1.1 to 4.8 ± 1.0 g/m2/h, p = 0.005) and increased stratum corneum hydration (from 30.1 ± 7.6 to 32.3 ± 8.1 a.u., p = 0.027) after 2 weeks. In addition, the amount change in sympathetic nervous activity was significantly reduced after ingesting the FA capsules compared with the placebo capsules (−0.7 ± 1.6 vs. 1.1 ± 1.4, p = 0.035). These findings suggest that FA supplementation decreases sympathetic nervous activity and strengthens SBF in healthy men.

scholarly journals Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum

2018 ◽  
Vol 98 (4) ◽  
pp. 421-427 ◽  
Author(s):  
T Berkers ◽  
D Visscher ◽  
G Gooris ◽  
J Bouwstra
Keyword(s):  
Stratum Corneum ◽  
Skin Barrier ◽  
Barrier Disruption ◽  
Lipid Organization

scholarly journals Effects of Cast Immobilisation on Skin Barrier Function

2020 ◽  
Vol 49 (6) ◽  
pp. 354-359
Author(s):  
Chin Yee Woo ◽  
Mark JA Koh ◽  
Winnie KY Fung ◽  
Cheri SH Chan ◽  
Chong Bing Chua ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Water Loss ◽  
Barrier Function ◽  
Skin Irritation ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Hair Density ◽  
Cast Immobilisation ◽  
Volar Surface

Introduction: Cast immobilisation remains the mainstay of treatment for various fractures in paediatric patients, yet patients commonly complain of skin irritation and discomfort. This study aimed to perform a qualitative and quantitative evaluation of the effects of cast immobilisation on the skin of children and adolescents. Materials and Methods: Patients aged 6–17 years of age with a fracture treated in a fiberglass short-arm or short-leg cast were recruited. Transepidermal water loss (TEWL), stratum corneum (SC) hydration, hair density and presence of any skin signs were assessed before and after cast. Patients were required to complete a weekly questionnaire to rate itch, malodour, warmth, and dampness of the skin under the cast. Results: A total of 60 subjects completed the study. Thirty-six patients received a short-arm cast; 24 received a short-leg cast. Upon cast removal, TEWL was significantly increased on the volar surface of the arms and legs (P <0.05), and the dorsal surface of the arm (P <0.05). Likewise, SC hydration was significantly increased at most sites (P <0.05), except the volar surface of the leg (P = 0.513). There was no change in hair density. Throughout the duration of casting, there was an increase in itch and malodour scores. Conclusions: Moderate but significant changes in TEWL, SC hydration and subjective symptoms were observed during the duration of cast immobilisation, demonstrating that cast immobilisation for up to 4 weeks exerts moderate adverse impact on patients’ skin. Further studies to explore the use of better materials for cast immobilisation to improve skin barrier function and overall patient satisfaction are warranted. Ann Acad Med Singapore 2020;49:285–93 Ann Acad Med Singapore 2020;49:354–59 Key words: Cast immobilisation, Transepidermal water loss, Stratum corneum hydration

scholarly journals The Effect of Ultra Fine Bubbles Water on the Human skin

2021 ◽  
Author(s):  
Yuji Kato ◽  
Tomoyuki Matsumoto ◽  
Setsuko Koura
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Barrier Function ◽  
Water Clusters ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Small Water ◽  
High Affinity ◽  
Normal Water ◽  
Large Clusters

A certain amount of water needs to be maintained in the stratum corneum of the skin in order to maintain the skin barrier function. Therefore, it is important to supply water to the stratum corneum of the skin to reduce trans epidermal water loss (TEWL). However, because normal water has large clusters, it is difficult to penetrate the stratum corneum of the skin. Therefore, it was considered that the use of Ultra-fine bubbles (UFB) water, which is said to have small water clusters, promotes penetration into the stratum corneum of the skin, and is useful for improving the skin barrier function. The artificial skin to which O2-UFB water was dripped had the highest water content and the lowest TEWL. It also had a high affinity for human skin. From these results, improvement of skin barrier function by O2-UFB water can be expected.

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