Primary tumor volume of nasopharyngeal carcinoma: prognostic significance for recurrence and survival rate

2008 ◽  
Vol 265 (S1) ◽  
pp. 115-120 ◽  
Author(s):  
Sau-Tung Chu ◽  
Pi-Hsiung Wu ◽  
Pesus Chou ◽  
Ching-Chih Lee
2009 ◽  
Vol 24 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Ching-Chih Lee ◽  
Hon-Yi Lin ◽  
Shih-Kai Hung ◽  
Dian-Kun Li ◽  
Hsu-Chueh Ho ◽  
...  

Aim Haptoglobin polymorphisms are associated with different cancers; however, the occurrence of nasopharyngeal carcinoma (NPC) in relation to haptoglobin polymorphisms has not been reported. In this study, the distribution of haptoglobin genotypes among patients with NPC was investigated and the prognostic significance of haptoglobin genotypes was further analyzed. Material and methods Haptoglobin genotypes were analyzed using polymerase chain reaction and electrophoresis. The genotypes were determined in the sera of 49 NPC patients and in 134 controls. Results The haptoglobin genotypes of patients with NPC were as follows: Hp 1–1, 2%; Hp 2–1, 39%; Hp 2–2, 59%. The frequency of the Hp 2–2 genotype was much higher in NPC patients than in control individuals (p=0.044). Furthermore, NPC patients with the Hp 2–2 genotype had advanced T stages (p=0.001) and larger primary tumor volumes (p=0.035) than those with Hp 2–1 or 1–1. Conclusion An increased frequency of the Hp 2–2 genotype was associated with NPC. The Hp 2 allele was also overexpressed in NPC patients. NPC patients with the Hp 2–2 genotype had advanced T stage and a larger primary tumor volume. Hp 2–2 may be a negative prognostic factor in NPC.


Author(s):  
Wai-Man Sze ◽  
Anne W.M Lee ◽  
Tsz-Kok Yau ◽  
Rebecca M.W Yeung ◽  
Kam-Ying Lau ◽  
...  

Cancer ◽  
2004 ◽  
Vol 100 (10) ◽  
pp. 2160-2166 ◽  
Author(s):  
Mu-Kuan Chen ◽  
Tony Hsiu-Hsi Chen ◽  
Jen-Pei Liu ◽  
Cheng-Chuan Chang ◽  
Wei-Chu Chie

2008 ◽  
Vol 35 (3) ◽  
pp. 376-380 ◽  
Author(s):  
Ching-Chih Lee ◽  
Hsu-Chueh Ho ◽  
Moon-Sing Lee ◽  
Shih-Hsuan Hsiao ◽  
Juen-Haur Hwang ◽  
...  

2008 ◽  
Vol 71 (9) ◽  
pp. 461-466 ◽  
Author(s):  
Sau-Tung Chu ◽  
Pi-Hsiung Wu ◽  
Yu-Yi Hou ◽  
Kuo-Ping Chang ◽  
Chao-Chuan Chi ◽  
...  

2011 ◽  
Vol 36 (6) ◽  
pp. 447-451 ◽  
Author(s):  
Guang-Uei Hung ◽  
Iuan-Sheng Wu ◽  
Hong-Shen Lee ◽  
Weir-Chiang You ◽  
Hui-Chuan Chen ◽  
...  

2008 ◽  
Vol 128 (1) ◽  
pp. 93-97 ◽  
Author(s):  
Ching-Chih Lee ◽  
Sau-Tung Chu ◽  
Hsu-Chueh Ho ◽  
Ching-Chieh Lee ◽  
Shih-Kai Hung

Sign in / Sign up

Export Citation Format

Share Document