scholarly journals Zona incerta as a therapeutic target in Parkinson’s disease

2019 ◽  
Vol 267 (3) ◽  
pp. 591-606 ◽  
Author(s):  
Krystyna Ossowska
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Zona Incerta

Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease

2016 ◽  
Vol 22 (10) ◽  
pp. 1305-1311 ◽  
Author(s):  
Juan Camilo Jurado-Coronel ◽  
Marco Avila-Rodriguez ◽  
Francisco Capani ◽  
Janneth Gonzalez ◽  
Valentina Echeverria Moran ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Therapeutic Target ◽  
Acetylcholine Receptors ◽  
Potential Therapeutic Target ◽  
Nicotinic Acetylcholine

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

2021 ◽  
Author(s):  
Johannes Burtscher ◽  
Muhammed Muazzam Kamil Syed ◽  
Hilal A. Lashuel ◽  
Grégoire P. Millet
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Promising Therapeutic Target

Coronal Gradient Echo MRI to Visualize the Zona Incerta for Deep Brain Stimulation Targeting in Parkinson’s Disease

2021 ◽  
pp. 1-8
Author(s):  
Ashesh A. Thaker ◽  
Kartik M. Reddy ◽  
John A. Thompson ◽  
Pamela David Gerecht ◽  
Mark S. Brown ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Regions Of Interest ◽  
Zona Incerta ◽  
Gradient Echo ◽  
Noise Ratio ◽  
Deep Brain

<b><i>Introduction:</i></b> Deep brain stimulation of the zona incerta is effective at treating tremor and other forms of parkinsonism. However, the structure is not well visualized with standard MRI protocols making direct surgical targeting unfeasible and contributing to inconsistent clinical outcomes. In this study, we applied coronal gradient echo MRI to directly visualize the rostral zona incerta in Parkinson’s disease patients to improve targeting for deep brain stimulation. <b><i>Methods:</i></b> We conducted a prospective study to optimize and evaluate an MRI sequence to visualize the rostral zona incerta in patients with Parkinson’s disease (<i>n</i> = 31) and other movement disorders (<i>n</i> = 13). We performed a contrast-to-noise ratio analysis of specific regions of interest to quantitatively assess visual discrimination of relevant deep brain structures in the optimized MRI sequence. Regions of interest were independently assessed by 2 neuroradiologists, and interrater reliability was assessed. <b><i>Results:</i></b> Rostral zona incerta and subthalamic nucleus were well delineated in our 5.5-min MRI sequence, indicated by excellent interrater agreement between neuroradiologists for region-of-interest measurements (&#x3e;0.90 intraclass coefficient). Mean contrast-to-noise ratio was high for both rostral zona incerta (6.39 ± 3.37) and subthalamic nucleus (17.27 ± 5.61) relative to adjacent white matter. There was no significant difference between mean signal intensities or contrast-to-noise ratio for Parkinson’s and non-Parkinson’s patients for either structure. <b><i>Discussion/Conclusion:</i></b> Our optimized coronal gradient echo MRI sequence delineates subcortical structures relevant to traditional and novel deep brain stimulation targets, including the zona incerta, with high contrast-to-noise. Future studies will prospectively apply this sequence to surgical planning and postimplantation outcomes.

scholarly journals Potassium Channels: A Potential Therapeutic Target for Parkinson’s Disease

2017 ◽  
Vol 34 (2) ◽  
pp. 341-348 ◽  
Author(s):  
Xiaoyan Chen ◽  
Bao Xue ◽  
Jun Wang ◽  
Haixia Liu ◽  
Limin Shi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Potassium Channels ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

Ribosomal s15: A novel therapeutic target for Parkinson's disease

2014 ◽  
Vol 29 (8) ◽  
pp. 990-990
Author(s):  
Sheila M. Fleming ◽  
Alberto J. Espay
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Novel Therapeutic

Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson’s Disease?

2011 ◽  
pp. 353-369
Author(s):  
Giselle M. Petzinger ◽  
Beth E. Fisher ◽  
Garnik Akopian ◽  
Ruth Wood ◽  
John P. Walsh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Therapeutic Target

scholarly journals Glucocerebrosidase as a therapeutic target for Parkinson’s disease

2020 ◽  
Vol 24 (4) ◽  
pp. 287-294 ◽  
Author(s):  
Yu Chen ◽  
Richard Sam ◽  
Pankaj Sharma ◽  
Lu Chen ◽  
Jenny Do ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target
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