Long-term follow-up of retinal nerve fiber layer cleavages in glaucoma patients and suspects

2018 ◽  
Vol 256 (10) ◽  
pp. 1945-1952 ◽  
Author(s):  
Yun Hsia ◽  
Chien-Chia Su ◽  
Tsing-Hong Wang ◽  
Chung-May Yang ◽  
Jehn-Yu Huang
2013 ◽  
Vol 32 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Fatma Yülek ◽  
Nagihan Uğurlu ◽  
Emine Akçay ◽  
Sücattin İlker Kocamıs¸ ◽  
Sıdıka Gerçeker ◽  
...  

2011 ◽  
Vol 89 (s248) ◽  
pp. 0-0
Author(s):  
R HERRERO LATORRE ◽  
E GARCIA MARTIN ◽  
M SATUE ◽  
E SANCHO MORO ◽  
J FERNANDEZ TIRADO

2018 ◽  
Vol 32 (6) ◽  
pp. 459 ◽  
Author(s):  
Eun Jung Lee ◽  
Sang Jin Kim ◽  
Jong Chul Han ◽  
Doo Ri Eo ◽  
Min Gyu Lee ◽  
...  

Author(s):  
Fauziyah Hayati

Glaukoma adalah kelompok penyakit nervus optikus yang ditandai dengan adanya kehilangan sel ganglion retina secara progresif. Glaukoma merupakan penyebab kebutaan ireversibel di dunia. Glaukoma tekanan normal adalah salah satu jenis dari glaukoma primer sudut terbuka yang ditandai dengan adanya neuropati optik dan tekanan bola mata kurang dari 21 mmHg. Laporan kasus ini menceritakan seorang pasien wanita umur 55 tahun dengan keluhan utama mata tidak nyaman dan buram pada kedua mata. Akan tetapi dari pemeriksaan oftalmologi, tajam penglihatan terbaik menunjukkan nilai normal yaitu 6/6, segmen anterior bola mata normal, dan tekanan bola mata normal, lapang pandang normal, kelainan hanya didapatkan dari funduskopi menunjukkan adanya cupping pada kedua mata dan Optical Coherence Tomography (OCT) yang menggambarkan adanya penipisan Retinal Nerve Fiber Layer (RNFL). Pasien diberikan obat topikal golongan prostaglandin analog dan follow up selama 3 tahun. Dari hasil follow up yang panjang, tingkat kerusakan karena glaukoma tidak terlihat signifikan. Akan tetapi setelah dua tahun, terjadi defek lapang pandang meningkat secara signifikan, sehingga perlu penambahan obat untuk mencapai target tekanan bola mata. Kesimpulan dalam kasus ini. Sangat penting untuk mengetahui diagnosis Normal Tension Glaucoma (NTG) agar dapat membedakan dari jenis glaukoma lainnya. Diagnosis dan terapi pada NTG masih menjadi tantangan bagi dokter mata. Pemeriksaan oftalmologi secara serial perlu dilakukan untuk mencegah progresifitas kerusakan nervus optikus. Follow up jangka panjang diperlukan pada semua kasus glaukoma termasuk NTG. Pengobatan NTG harus disesuaikan sesuai dengan target tekanan bola mata yang diperlukan.


Author(s):  
Hemma Resch ◽  
Florian Schwarzhans ◽  
Florian Frommlet ◽  
Anton Hommer ◽  
Philipp Fuchs ◽  
...  

Abstract Purpose Our previously introduced multivariate model, compensating for intersubject variability, was applied to circumpapillary retinal nerve fiber layer (RNFL) values measured with optical coherence tomography in glaucoma suspects with or without prior progressive optic disc (OD) change in a series of confocal scanning laser tomography (CSLT, HRT III) measurements. Methods In this prospective study, OD change during CSLT follow-up was determined with strict, moderate, and liberal criteria of the topographic change analysis (TCA). Model compensation (MC) as well as age compensation (AC) was applied to RNFL sectors (RNFLMC vs. RNFLAC). Diagnostic performance of RNFLMC vs. RNFLAC was tested with an area under the receiver operating characteristic (AUROC) and was compared between methods. Results Forty-two glaucoma suspects were included. Patients without prior progressive OD change during the CSLT follow-up (= stable) had thicker RNFL thickness values in most areas and for all progression criteria. RNFLMC AUROC for the global RNFL (0.719) and the inferior quadrant (0.711) performed significantly better compared with RNFLAC AUROC (0.594 and 0.631) to discriminate between stable and progressive glaucoma suspects as defined by the moderate criteria of CSLT progression analysis (p = 0.028; p = 0.024). Conclusion MC showed a slight but significant improvement in detection of subjects with prior progressive OD change among a group of glaucoma suspects, when compared to AC, which is the compensation method commonly used during OCT data evaluation in daily routine. Further studies are warranted to validate the present results.


2012 ◽  
Vol 05 (02) ◽  
pp. 91
Author(s):  
Ahmad A Aref ◽  
Donald L Budenz ◽  
◽  

Clinical discrimination between myopic tilted optic discs and glaucomatous optic neuropathy is often challenging, especially when considering that myopia is a risk factor for the development of glaucoma. Myopic tilted discs are usually larger than average, with associated relative cupping and thinner neuroretinal rim tissue. Histopathologic study has revealed thinner parapapillary retinal tissue in these eyes. Optical coherence tomography (OCT)-measured average retinal nerve fiber layer (RNFL) thickness has been found to decrease with longer axial length and higher myopic refractive error. Parapapillary RNFL quadrant and clock-hour analyses result in a higher false-positive rate in myopic eyes. Careful slit-lamp examination, quality baseline stereoscopic disc photographs, and frequent serial visual field testing are essential to the follow-up of myopic individuals with suspected glaucoma. A novel diagnostic parameter, OCT-derived ganglion cell analysis, may prove to be useful in the diagnosis and follow-up of these individuals.


Eye ◽  
2021 ◽  
Author(s):  
Gamze Yıldırım Biçer ◽  
Kürşad Ramazan Zor ◽  
Kadir Eren Biçer ◽  
Erkut Küçük ◽  
Esin Benli Küçük

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