scholarly journals Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

2021 ◽  
Author(s):  
Anna Cornelius ◽  
Daniel Pilger ◽  
Aline Riechardt ◽  
Emanuel Reitemeyer ◽  
Anne Rübsam ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fibre ◽  
Optical Coherence Tomography Angiography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Nerve Fibre Layer ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
The Mean ◽  
Nerve Fibre Layer

Abstract Purpose To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical coherence tomography angiography (OCTA). Methods In this prospective study a total of 26 POAG and 23 PXG eyes were included. All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters. Results The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57% ± 3.57% vs. 34.92% ± 2.11%, p = 0.007). The mean PD parameters for the superficial peripapillary plexus (40.98% ± 3.04% vs. 42.09% ± 2.29%, p = 0.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm2 ± 0.1 mm2 vs. 0.23 mm2 ± 0.09 mm2) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97% ± 1.11% vs. 33.35% ± 0.95%, p = 0.194) and peripapillary plexus PD (46.65% ± 0.83% vs. 46.95% ± 0.5%, p = 0.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (p < 0.001, p = 0.032). Conclusion The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.

scholarly journals Retinal nerve fibre layer thickness measured by spectral domain optical coherence tomography amongst early primary open-angle glaucoma patients at Hospital Melaka

2020 ◽  
Vol 2 (3) ◽  
pp. 203-218
Author(s):  
Anhar Hafiz Silim ◽  
Raja Norliza Raja Omar ◽  
Othmaliza Othman ◽  
Rona Asnida Nasaruddin ◽  
Norshamsiah Md Din
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Nerve Fibre Layer ◽  
Open Angle ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Introduction: Glaucoma is second only to cataract as a cause of blindness worldwide and Asians account for almost half the cases. Retinal nerve fibre layer (RNFL) assessment is an important objective method for diagnosis and monitoring of glaucoma as it develops earlier than the development of visual field defects. Purpose: To estimate the proportion of primary open-angle glaucoma (POAG) patients with normal RNFL thickness (RNFLT) amongst early POAG patients who were under follow-up at the Ophthalmology Department, Hospital Melaka (Melaka, Malaysia). Study design: Observational cross-sectional study. Materials and methods: Consecutive sampling of 64 POAG patients who were diagnosed as early POAG as defined by the Glaucoma Staging System 2 (GSS 2) into stage 1 and 2 on Octopus visual field test were recruited in this study. Data collected included demographic data, refraction, slit-lamp examination, intraocular pressure (IOP), gonioscopy, peripapillary retinal nerve fibre layer thickness (RNFLT) measured by spectral-domain optical coherence tomography (SD-OCT), and fundus photography. Results: Among 64 eyes, 57.8% were found to have normal and 42.2% to have abnormal RNFLT classification. There was no difference in terms of age, gender or ethnicity between those with normal and abnormal RNFLT. Mean IOP at presentation, mean duration of POAG, and mean spherical dioptres were compared between the two groups. Only mean spherical dioptres showed a significant difference between the two groups, p < 0.001. An increase of spherical dioptres also had a moderate positive correlation with RNFLT in most optic disc quadrants except the nasal, temporal, superonasal, and inferonasal quadrants. Conclusion: OCT cannot be used as a diagnostic tool alone, especially in early glaucoma, as it showed a normal RNFLT in almost half the patients. RNFLT in early POAG had significant correlation with spherical dioptres in most quadrants.

scholarly journals The Role of Optical Coherence Tomography Angiography in Moderate and Advanced Primary Open-Angle Glaucoma

2021 ◽  
Author(s):  
Yadollah Eslami ◽  
Sepideh Ghods ◽  
Massood Mohammadi ◽  
Mona Safizadeh ◽  
Ghasem Fakhraie ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Mean Deviation ◽  
Optical Coherence ◽  
Open Angle ◽  
The Mean ◽  
Inferior Quadrant

Abstract Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG.Methods: In this cross-sectional study 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Visual field (VF) was evaluated by Swedish interactive threshold algorithm and 24-2 and 10-2 patterns. The correlation between structure and vasculature and the mean deviation (MD) of the VFs was evaluated by a partial correlation coefficient. The area under the receiver operating characteristic curve (AUC) was applied for assessing the power of variables for discrimination moderate from advanced POAG.Results: Superior cpRNFL, superior GCC, whole image vessel density (wiVD) of the ONH area, and vessel density in inferior quadrant of perifovea had the strongest correlation with the mean deviation (MD) of the VF 24-2 (r= .351, .558, .649 and .397; p< .05). The greatest AUCs belonged to inferior cpRNFL (.789), superior GCC (.818), vessel density of the inferior hemifield of ONH area (.886), and vessel density in inferior quadrant of perifovea (.833) without statistically significant difference in pairwise comparison.Conclusion: Vasculature has a stronger correlation than the structure with MD in moderate and advanced POAG and is as accurate as structure in discrimination moderate from advanced POAG.

A comparison of two optical coherence tomography–angiography devices in pseudoexfoliation glaucoma versus primary open-angle glaucoma and healthy subjects

2018 ◽  
Vol 29 (6) ◽  
pp. 636-644 ◽  
Author(s):  
Gema Rebolleda ◽  
Ane Pérez-Sarriegui ◽  
Victoria De Juan ◽  
Sara Ortiz-Toquero ◽  
Francisco J Muñoz-Negrete
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence Tomography Angiography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Capillary Density ◽  
Optical Coherence ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
Retinal Nerve Fiber

Purpose: To compare peripapillary vascular parameters derived from two optical coherence tomography angiography devices in pseudoexfoliation glaucoma, primary open-angle glaucoma, and healthy controls and to evaluate their diagnostic accuracy. Methods: Observational, cross-sectional study. In total, 20 eyes with pseudoexfoliation glaucoma, 20 primary open-angle glaucoma eyes matched by peripapillary retinal nerve fiber layer thickness, and 20 control eyes were recruited. Participants underwent standard automated perimetry and peripapillary retinal nerve fiber layer analysis by Optovue and Cirrus optical coherence tomography. Vascular parameters provided by Angiovue and Angioplex optical coherence tomography angiography were compared. Their diagnostic accuracy and correlation with structural and functional parameters were assessed. Results: All peripapillary optical coherence tomography angiography vascular parameters were significantly different among groups (all p < 0.05). The whole image capillary density and peripapillary capillary density by Angiovue were significantly lower in pseudoexfoliation glaucoma compared with primary open-angle glaucoma (p = 0.009 and p = 0.001, respectively). Conversely, vascular parameters by Angioplex were not statistically different between primary open-angle glaucoma and pseudoexfoliation glaucoma. A good correlation was found using Angiovue between whole image capillary density and visual field mean deviation (0.758, p < 0.001), peripapillary capillary density and visual field mean deviation (0.729, p = 0.001), and peripapillary capillary density and peripapillary retinal nerve fiber layer thickness in eyes with pseudoexfoliation glaucoma (0.716, p = 0.001). Angiovue parameters showed higher area under the receiver operating characteristic curves than Angioplex to discriminate among groups. Conclusion: Only Angiovue detected a significantly lower capillary density in pseudoexfoliation glaucoma compared to primary open-angle glaucoma at similar glaucoma damage. Both, Angiovue and Angioplex demonstrated a decreased capillary density in glaucoma eyes compared to healthy eyes. Furthermore, Angiovue-derived vascular parameters showed better correlation with functional and structural parameters and a higher diagnostic capacity to discriminate among groups compared to Angioplex.

The volume of peripapillary vessels within the retinal nerve fibre layer: an optical coherence tomography angiography study of normal subjects

2017 ◽  
Vol 102 (5) ◽  
pp. 611-621 ◽  
Author(s):  
Davide Allegrini ◽  
Giovanni Montesano ◽  
Paolo Fogagnolo ◽  
Alfredo Pece ◽  
Roberta Riva ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fibre ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Tissue ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
The Mean ◽  
Nerve Fibre Layer

Background/aimsTo investigate the contribution of vascular volume calculated by optical coherence tomography angiography (OCTA) to the measurement of peripapillary retinal nerve fibre layer (RNFL) thickness.MethodsWe used OCTA scans to build volumetric maps of the RNFL angiograms by thresholding the decorrelation images and summing the number of white pixels along the z-axis at each location. We used these maps to calculate the contribution of the vascular tissue to the RNFL thickness.ResultsWe analysed 51 eyes from 36 subjects. The mean RNFL volume calculated on the peripapillary region was 0.607±0.045 mm3 and the mean vessel volume was 0.217±0.035 mm3, with a mean vessel/total RNFL ratio of 35.627%±3.942%. When evaluated in the peripapillary circular section, the total contribution of the vascular tissue to the global RNFL thickness was 29.071%±3.945%. The superior and inferior sectors showed the highest percentage of vascular tissue within the RNFL circular profile (31.369% and 34.788% respectively).ConclusionsWe found that the vascular contribution to the RNFL thickness is 29.07±3.945%. This is much higher than what has been reported from calculations made on the structural OCT alone (13% reported by Hood et al and 11.3%±1.6% for the Cirrus OCT and 11.8%±1.4% for the Spectralis OCT reported by Patel et al). We conclude that evaluation of the vascular tissue contribution to the RNFL thickness with OCTA might be useful when performing precise quantification of the neuronal tissue.

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