scholarly journals The Role of Optical Coherence Tomography Angiography in Moderate and Advanced Primary Open-Angle Glaucoma

2021 ◽  
Author(s):  
Yadollah Eslami ◽  
Sepideh Ghods ◽  
Massood Mohammadi ◽  
Mona Safizadeh ◽  
Ghasem Fakhraie ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Mean Deviation ◽  
Optical Coherence ◽  
Open Angle ◽  
The Mean ◽  
Inferior Quadrant

Abstract Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG.Methods: In this cross-sectional study 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Visual field (VF) was evaluated by Swedish interactive threshold algorithm and 24-2 and 10-2 patterns. The correlation between structure and vasculature and the mean deviation (MD) of the VFs was evaluated by a partial correlation coefficient. The area under the receiver operating characteristic curve (AUC) was applied for assessing the power of variables for discrimination moderate from advanced POAG.Results: Superior cpRNFL, superior GCC, whole image vessel density (wiVD) of the ONH area, and vessel density in inferior quadrant of perifovea had the strongest correlation with the mean deviation (MD) of the VF 24-2 (r= .351, .558, .649 and .397; p< .05). The greatest AUCs belonged to inferior cpRNFL (.789), superior GCC (.818), vessel density of the inferior hemifield of ONH area (.886), and vessel density in inferior quadrant of perifovea (.833) without statistically significant difference in pairwise comparison.Conclusion: Vasculature has a stronger correlation than the structure with MD in moderate and advanced POAG and is as accurate as structure in discrimination moderate from advanced POAG.

Quantitative assessment of macular and peripapillary microvasculature using optical coherence tomography angiography in glaucomatous versus healthy eyes

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Amr M Sanad ◽  
Mohamed M Mahgoub ◽  
Weam M Ebeid ◽  
Rabab A Mahmoud
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Optical Coherence ◽  
Open Angle ◽  
University Hospitals ◽  
Microvascular Changes ◽  
Group 2

Abstract Background Glaucoma is the leading cause of irreversible blindness worldwide. With the growing burden of glaucoma, we looked for better tools for early diagnosis and monitoring. Aim of the Work using optical coherence tomography angiography (OCTA) vessel density (VD) to document, quantify and compare microvasculature changes in macula and peripapillary region between healthy and moderate to severe primary open angle glaucoma eyes. Patients and Methods A comparative interventional prospective study was conducted on 28 eyes of 14 subjects, recruited from Ain Shams University hospitals outpatient clinic, and were subjected to imaging procedure during the period from January 2020 to May 2020. Subjects were divided into two groups: Group 1 of 14 eyes of 9 patients with moderate to severe primary open angle glaucoma (POAG), and group 2 of 14 eyes of 7 healthy sex and age-matched controls. Results a statistically significant decrease was found in VD in the peripapillary region (P &lt; 0.001) and superficial macular regions in glaucoma subjects (P &lt; 0.001). Conclusion OCTA proved a quantitative decrease in both peripapillary and macular vessel density as a parameter of microvascular changes associated with moderate to severe POAG. These results reflect damage to tissues relevant to the pathophysiology of POAG demonstrating OCTA importance with respect to diagnosing glaucoma and understanding the pathophysiology of this disease and, guiding future studies to evaluate more potential uses of this technology in the actual assessment of patients with glaucoma.

scholarly journals A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173930 ◽  
Author(s):  
Harsha L. Rao ◽  
Zia S. Pradhan ◽  
Robert N. Weinreb ◽  
Mohammed Riyazuddin ◽  
Srilakshmi Dasari ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Optical Coherence ◽  
Open Angle ◽  
Diagnostic Ability

scholarly journals Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

2021 ◽  
Author(s):  
Anna Cornelius ◽  
Daniel Pilger ◽  
Aline Riechardt ◽  
Emanuel Reitemeyer ◽  
Anne Rübsam ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fibre ◽  
Optical Coherence Tomography Angiography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Nerve Fibre Layer ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
The Mean ◽  
Nerve Fibre Layer

Abstract Purpose To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical coherence tomography angiography (OCTA). Methods In this prospective study a total of 26 POAG and 23 PXG eyes were included. All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters. Results The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57% ± 3.57% vs. 34.92% ± 2.11%, p = 0.007). The mean PD parameters for the superficial peripapillary plexus (40.98% ± 3.04% vs. 42.09% ± 2.29%, p = 0.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm2 ± 0.1 mm2 vs. 0.23 mm2 ± 0.09 mm2) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97% ± 1.11% vs. 33.35% ± 0.95%, p = 0.194) and peripapillary plexus PD (46.65% ± 0.83% vs. 46.95% ± 0.5%, p = 0.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (p < 0.001, p = 0.032). Conclusion The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.

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