A longitudinal study on urinary cadmium and renal tubular protein excretion of nickel–cadmium battery workers after cessation of cadmium exposure

In this study, we have shown that intravenously administered antisense oligodeoxynucleotide (ODN) was demonstrated to be taken up by tubular epithelium, after which it blocked mRNA expression of target genes in normal and nephritic rats. Therefore, we injected osteopontin (OPN) antisense ODN to Goodpasture syndrome (GPS) rats every second day between days 27 and 35, the time when renal OPN expression increased and interstitial monocyte infiltration was aggravated. In parallel to blockade of tubular OPN expression, this treatment significantly attenuated monocyte infiltration and preserved renal plasma flow in GPS rats at day 37, compared with sense ODN-treated and untreated GPS rats. No significant changes were observed in OPN mRNA level by RT-PCR and histopathology of the glomeruli after ODN treatment, which was compatible with an absence of differences in the urinary protein excretion rate. In conclusion, OPN expressed by tubular epithelium played a pivotal role in mediating peritubular monocyte infiltration consequent to glomerular disease.

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Determination of cadmium in urine and observations on urinary cadmium and protein excretion in men exposed to cadmium oxide dust

Biochemical Journal ◽

10.1042/bj0610698 ◽

1955 ◽

Vol 61 (4) ◽

pp. 698-701 ◽

Cited By ~ 15

Author(s):

J. C. Smith ◽

J. E. Kench ◽

R. E. Lane

Keyword(s):

Cadmium Oxide ◽

Urinary Cadmium ◽

Cadmium In Urine ◽

Protein Excretion

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Serial changes in urinary cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies

Toxicology Letters ◽

10.1016/j.toxlet.2007.10.013 ◽

2008 ◽

Vol 176 (2) ◽

pp. 124-130 ◽

Cited By ~ 14

Author(s):

Etsuko Kobayashi ◽

Yasushi Suwazono ◽

Ryumon Honda ◽

Mirei Dochi ◽

Muneko Nishijo ◽

...

Keyword(s):

Rice Paddies ◽

Tubular Injury ◽

Urinary Cadmium ◽

Renal Tubular

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Variance and covariance heterogeneity analysis for detection of metabolites associated with cadmium exposure

Statistical Applications in Genetics and Molecular Biology ◽

10.1515/sagmb-2013-0041 ◽

2014 ◽

Vol 13 (2) ◽

Cited By ~ 3

Author(s):

Beatriz Valcarcel Salamanca ◽

Timothy M.D. Ebbels ◽

Maria De Iorio

Keyword(s):

Hierarchical Models ◽

Urinary Metabolites ◽

Potential Effect ◽

Environmental Pollutant ◽

Cadmium Exposure ◽

Urinary Cadmium ◽

Bayesian Hierarchical ◽

Metabolic Traits ◽

Statistical Framework ◽

Heterogeneity Analysis

AbstractIn this study, we propose a novel statistical framework for detecting progressive changes in molecular traits as response to a pathogenic stimulus. In particular, we propose to employ Bayesian hierarchical models to analyse changes in mean level, variance and correlation of metabolic traits in relation to covariates. To illustrate our approach we investigate changes in urinary metabolic traits in response to cadmium exposure, a toxic environmental pollutant. With the application of the proposed approach, previously unreported variations in the metabolism of urinary metabolites in relation to urinary cadmium were identified. Our analysis highlights the potential effect of urinary cadmium on the variance and correlation of a number of metabolites involved in the metabolism of choline as well as changes in urinary alanine. The results illustrate the potential of the proposed approach to investigate the gradual effect of pathogenic stimulus in molecular traits.

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