Mode and determination of the initial contraction stage in the mouse embryo heart

2005 ◽  
Vol 211 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Kiyomasa Nishii ◽  
Yosaburo Shibata
Keyword(s):  
Mouse Embryo ◽  
Embryo Heart ◽  
Contraction Stage

Determination of left–right patterning of the mouse embryo by artificial nodal flow

Nature ◽  
2002 ◽  
Vol 418 (6893) ◽  
pp. 96-99 ◽  
Author(s):  
Shigenori Nonaka ◽  
Hidetaka Shiratori ◽  
Yukio Saijoh ◽  
Hiroshi Hamada
Keyword(s):  
Mouse Embryo ◽  
Nodal Flow

Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis

Development ◽  
1999 ◽  
Vol 126 (12) ◽  
pp. 2589-2596 ◽  
Author(s):  
C. Chazaud ◽  
P. Chambon ◽  
P. Dolle
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Mouse Embryo ◽  
Time Course ◽  
Retinoic Acid Receptor ◽  
Mouse Embryos ◽  
Anteroposterior Patterning ◽  
Heart Looping ◽  
Left Right Asymmetry

Determination of the left-right position (situs) of visceral organs involves lefty, nodal and Pitx2 genes that are specifically expressed on the left side of the embryo. We demonstrate that the expression of these genes is prevented by the addition of a retinoic acid receptor pan-antagonist to cultured headfold stage mouse embryos, whereas addition of excess retinoic acid leads to their symmetrical expression. Interestingly, both treatments lead to randomization of heart looping and to defects in heart anteroposterior patterning. A time course analysis indicates that only the newly formed mesoderm at the headfold-presomite stage is competent for these retinoid effects. We conclude that retinoic acid, the active derivative of vitamin A, is essential for heart situs determination and morphogenesis.

The development of the conduction system in the mouse embryo heart

1980 ◽  
Vol 80 (1) ◽  
pp. 28-45 ◽  
Author(s):  
Sz. Virágh ◽  
C.E. Challice
Keyword(s):  
Mouse Embryo ◽  
Conduction System ◽  
Embryo Heart

The development of the conduction system in the mouse embryo heart

1977 ◽  
Vol 56 (2) ◽  
pp. 397-411 ◽  
Author(s):  
Sz. Virágh ◽  
C.E. Challice
Keyword(s):  
Mouse Embryo ◽  
Conduction System ◽  
Embryo Heart

The development of the conduction system in the mouse embryo heart

1982 ◽  
Vol 89 (1) ◽  
pp. 25-40 ◽  
Author(s):  
Sz. Virágh ◽  
C.E. Challice
Keyword(s):  
Mouse Embryo ◽  
Conduction System ◽  
Embryo Heart
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