Secondary esophageal squamous cell carcinoma after hematopoietic stem cell transplantation

2021 ◽  
Author(s):  
Kosuke Nomura ◽  
Toshiro Iizuka ◽  
Daisuke Kaji ◽  
Yuki Asano-Mori ◽  
Yorinari Ochiai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Esophageal Squamous Cell Carcinoma ◽  
Stem Cell Transplantation ◽  
Cell Carcinoma ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Squamous Cell ◽  
Hematopoietic Stem

Oral squamous cell carcinoma after hematopoietic stem cell transplantation: A report of five cases

Toukeibu Gan ◽  
2014 ◽  
Vol 40 (1) ◽  
pp. 43-50
Author(s):  
Yuki Takagi ◽  
Haruki Sato ◽  
Hidenori Sakuma ◽  
Haruna Noda ◽  
Ryosuke Naganawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Oral Squamous Cell Carcinoma ◽  
Stem Cell Transplantation ◽  
Cell Carcinoma ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Squamous Cell ◽  
Hematopoietic Stem

scholarly journals Two Lip Carcinomas following Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report and Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Nouha Dammak ◽  
Latifa Berrezouga ◽  
Manel Njima ◽  
Ines Lahouel ◽  
Mehdi Khemiss ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Carcinoma ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Squamous Cell ◽  
Allogeneic Bone ◽  
Hematopoietic Stem

Background. Secondary solid cancers are severe complications in patients who have undergone allogeneic hematopoietic stem cell transplantation (AHSCT) for malignant and nonmalignant lymphohematopoietic diseases. Objective. The aim of this work was to report a case of two lip carcinomas following AHSCT and to warn doctors about the importance of regular check-ups of patients who have received HSCT. Observation. A 57-year-old man was referred by the dermatology department for the management of exophytic budding lesions on the lower lip evolving since 5 months. The patient was in complete remission following allogeneic bone marrow transplantation for acute myeloid leukemia since five years. Clinical and histological findings confirmed the diagnosis of a squamous cell carcinoma of the two lesions. Conclusion. It is of paramount importance to seek an oral squamous cell carcinoma in the presence of persistent lesions in HSCT recipients.

scholarly journals Voriconazole-Induced Squamous Cell Carcinoma after Hematopoietic Stem Cell Transplantation Showing Early-Stage Vascular Invasion

2020 ◽  
Vol 7 (3) ◽  
pp. 48-52 ◽  
Author(s):  
Yumi Sawada ◽  
Yasuo Nakai ◽  
Naho Yokota ◽  
Koji Habe ◽  
Akinobu Hayashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Carcinoma ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Vascular Invasion ◽  
Immunocompromised Patients ◽  
Hematopoietic Stem

Voriconazole is a triazole antifungal agent used for the prevention and treatment of fungal infections in immunocompromised patients. Prolonged voriconazole therapy may induce phototoxicity and lead to the development of malignant neoplasms of the epidermis, such as squamous cell carcinoma (SCC), especially in immunocompromised patients. We report a case of voriconazole-induced phototoxicity and SCC occurring after hematopoietic stem cell transplantation (HSCT) in a 56-year-old man with primary myelofibrosis. The patient developed chronic graft-versus-host disease (GVHD) post-transplantation and had been receiving long-term immunosuppressive treatment. A year after the initiation of voriconazole therapy for prophylaxis, he developed keratotic erythema, followed by SCC with vascular invasion after three years. A review of SCC in HSCT recipients suggests that the prolonged use of voriconazole is regarded as a risk for SCC after HSCT in patients with chronic GVHD on immunosuppressive therapy. Moreover, a histological examination of the completely resected tumor revealed vascular invasion in this case, although neither the clinical features nor the histological findings of the preoperative biopsy suggested invasive carcinoma. This case may partially explain why voriconazole-associated SCCs show a more aggressive clinical course than non-voriconazole SCCs do.

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