How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse ( Peromyscus maniculatus )

1997 ◽  
Vol 100 (2) ◽  
pp. 182-188 ◽  
Author(s):  
B. F. McAllister ◽  
I. F. Greenbaum
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mouse ◽  
Fragile Sites ◽  
Common Fragile Sites ◽  
Chromosomal Fragile Sites

scholarly journals Chromosomal Instability at Fragile Sites in Blue Foxes, Silver Foxes, and Their Interspecific Hybrids

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1743
Author(s):  
Marta Kuchta-Gładysz ◽  
Ewa Wójcik ◽  
Anna Grzesiakowska ◽  
Katarzyna Rymuza ◽  
Olga Szeleszczuk
Keyword(s):  
Interspecific Hybrids ◽  
Genome Stability ◽  
Diploid Number ◽  
Fragile Sites ◽  
B Chromosomes ◽  
Silver Fox ◽  
Chromosomal Breaks ◽  
Blue Fox ◽  
Chromosomal Fragile Sites ◽  
Karyotypic Variation

A cytogenetic assay based on fragile sites (FS) enables the identification of breaks, chromatid gaps, and deletions. In healthy individuals, the number of these instabilities remains low. Genome stability in these species is affected by Robertsonian translocations in the karyotype of the blue fox and by B chromosomes in the silver fox. The aims of the study were to characterise the karyotype of blue foxes, silver foxes, and their hybrids and to identify chromosomal fragile sites used to evaluate genome stability. The diploid number of A chromosomes in blue foxes ranged from 48 to 50, while the number of B chromosomes in silver foxes varied from one to four, with a constant number of A chromosomes (2n = 34). In interspecific hybrids, both types of karyotypic variation were identified, with the diploid number of A chromosomes ranging from 40 to 44 and the number of B chromosomes varying from 0 to 3. The mean frequency of FS in foxes was 4.06 ± 0.19: 4.61 ± 0.37 in blue foxes, 3.46 ± 0.28 in silver foxes, and 4.12 ± 0.22 in hybrids. A relationship was identified between an increased number of A chromosomes in the karyotype of the hybrids and the frequency of chromosomal breaks. The FS assay was used as a biomarker for the evaluation of genomic stability in the animals in the study.

Family study of common fragile sites

1989 ◽  
Vol 82 (2) ◽  
pp. 191-193 ◽  
Author(s):  
Yoshitsugu Sugio ◽  
Yoshikazu Kuroki
Keyword(s):  
Family Study ◽  
Fragile Sites ◽  
Common Fragile Sites

Genic variation in the deer mouse, Peromyscus maniculatus, in a small geographic area

Genetica ◽  
1981 ◽  
Vol 57 (1) ◽  
pp. 65-74 ◽  
Author(s):  
P. K. Price ◽  
M. L. Kennedy
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mouse ◽  
Geographic Area ◽  
Genic Variation

Cutis verticis gyrata and chromosomal fragile sites

1991 ◽  
Vol 38 (2-3) ◽  
pp. 249-250 ◽  
Author(s):  
S. A. Musumeci ◽  
R. Ferri ◽  
M. Viglianesi ◽  
M. Elia ◽  
R. M. Ragusa ◽  
...  
Keyword(s):  
Fragile Sites ◽  
Cutis Verticis Gyrata ◽  
Chromosomal Fragile Sites
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