Secondary flow loss in modern axial compressors is considered to be the prime reason for the reduction of overall isentropic efficiency in these engine components. This paper presents a new methodology to diminish blade secondary loss and endwall loss by an axis-asymmetric modification of endwalls using an automated multiobjective optimizer in conjunction with 3D-RANS-flow-simulations. In order to obtain a favorable design for a wide operating range, the most important operating-points are considered in the optimization process. The existing multiobjective optimization package is enhanced by implementation of DLR’s in-house 3D-flow-solver TRACE. A straightforward stator optimization was performed for a 3D-process-chain test run. Finally, the novel endwall design technique is introduced and the first optimization results and further studies are discussed.