Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts

2005 ◽  
Vol 40 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Yoh Zen ◽  
Kenichi Harada ◽  
Motoko Sasaki ◽  
Koichi Tsuneyama ◽  
Kazuhiro Matsui ◽  
...  
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Autoimmune Hepatitis ◽  
Viral Hepatitis ◽  
Bile Ducts ◽  
Chronic Viral Hepatitis ◽  
Biliary Cirrhosis ◽  
Bile Duct Lesions

scholarly journals Biliary Epithelial Apoptosis, Autophagy, and Senescence in Primary Biliary Cirrhosis

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Bile Ducts ◽  
Experimental Studies ◽  
Cholestatic Liver Disease ◽  
Biliary Cirrhosis ◽  
High Prevalence ◽  
Small Bile Duct ◽  
Bile Duct Lesions ◽  
Autoimmune Pathogenesis

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized serologically by the high prevalence of anti-mitochondrial autoantibodies (AMAs) and histologically by the cholangitis of small bile ducts, eventually followed by extensive loss of the small bile duct. An autoimmune pathogenesis is suggested by clinical and experimental studies, but there remain issues regarding the etiology, the significance of AMAs in the pathogenesis of bile duct lesions, and so on. The unique properties of apoptosis in biliary epithelial cells (BECs), in which there is exposure of autoantigen to the effectors of the immune system, are proposed to be a cause of bile duct lesions in PBC. Recent progress disclosed that cellular senescence and autophagy are involved in bile duct lesions in PBC. Senescent BECs may modulate the periductal microenvironment by expressing senescence-associated secretory phenotypes, including various chemokines, and contribute to the pathogenesis of bile duct lesions in PBC.

scholarly journals Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Bile Ducts ◽  
Causative Factor ◽  
Biliary Cirrhosis ◽  
Novel Approach ◽  
Bile Duct Damage ◽  
Chronic Nonsuppurative Destructive Cholangitis ◽  
Bile Duct Lesions

Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. The autoimmune-mediated pathogenesis of bile duct lesions, including the significance of AMAs, triggers of the autoimmune process, and so on remain unclear. We have reported that cellular senescence in biliary epithelial cells (BECs) may be involved in bile duct lesions and that autophagy may precede the process of biliary epithelial senescence in PBC. Interestingly, BECs in damaged bile ducts show characteristicsof cellular senescence and autophagy in PBC. A suspected causative factor of biliary epithelial senescence is oxidative stress. Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC.

Pathology and Immunopathology of Primary Biliary Cirrhosis With Emphasis On Bile Duct Lesions: Recent Progress

1995 ◽  
Vol 15 (04) ◽  
pp. 313-328 ◽  
Author(s):  
Yasuni Nakanuma ◽  
Koichi Tsuneyama ◽  
M. Gershwin ◽  
Mitsue Yasoshima
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Recent Progress ◽  
Biliary Cirrhosis ◽  
Bile Duct Lesions

Immunopathology of Bile Duct Lesions of Primary Biliary Cirrhosis

2017 ◽  
pp. 73-84
Author(s):  
Hayato Baba ◽  
Ayumi Sugitani ◽  
Ryusei Takahashi ◽  
Kouki Kai ◽  
Yuki Moritoki ◽  
...  
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Bile Duct Lesions

scholarly journals Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis

2013 ◽  
Vol 67 (5) ◽  
pp. 396-402 ◽  
Author(s):  
Kenichi Harada ◽  
Yuko Kakuda ◽  
Yasunori Sato ◽  
Hiroko Ikeda ◽  
Shinji Shimoda ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Bile Duct Lesions

Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss

2005 ◽  
Vol 205 (4) ◽  
pp. 451-459 ◽  
Author(s):  
Motoko Sasaki ◽  
Hiroko Ikeda ◽  
Hironori Haga ◽  
Toshiaki Manabe ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Bile Ducts ◽  
Biliary Cirrhosis

Jaundice

2013 ◽  
pp. 207-232
Author(s):  
Daniel Marks ◽  
Marcus Harbord
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Obstructive Jaundice ◽  
Autoimmune Hepatitis ◽  
Viral Hepatitis ◽  
Alcoholic Hepatitis ◽  
Serum Bilirubin ◽  
Biliary Cirrhosis ◽  
Drug Induced ◽  
Elevated Bilirubin ◽  
Yellow Pigmentation

Assessment and causes of jaundice Viral hepatitis Alcoholic hepatitis Drug-induced hepatitis Autoimmune hepatitis Haemochromatosis Wilson’s disease Primary biliary cirrhosis Ischaemic hepatitis Obstructive jaundice Acholuric jaundice Sepsis Jaundice refers to yellow pigmentation of the skin and sclera caused by elevated bilirubin levels. It is usually clinically detectable when serum bilirubin concentrations rise above 60...

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