Prognostic effects of causative virus in hepatocellular carcinoma according to the Japan integrated staging (JIS) score

2005 ◽  
Vol 40 (10) ◽  
pp. 972-979 ◽  
Author(s):  
Shoji Kubo ◽  
Hiromu Tanaka ◽  
Taichi Shuto ◽  
Shigekazu Takemura ◽  
Takatsugu Yamamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Jis Score

scholarly journals Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study

2019 ◽  
Author(s):  
Yan Mardian ◽  
Yoshihiko Yano ◽  
Neneng Ratnasari ◽  
Lina Choridah ◽  
Widya Wasityastuti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Large Scale ◽  
Cox Regression ◽  
Clinical Laboratory ◽  
Multivariable Analysis ◽  
Lumbar Vertebra ◽  
Intramuscular Fat ◽  
Skeletal Muscle Index ◽  
Computed Tomography Images ◽  
Jis Score

Abstract Background A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Japanese patients.Methods SMI and mean muscle attenuation (MA) were evaluated using computed tomography images of the third lumbar vertebra (L3) in a prospective cohort of 100 Indonesian HCC patients. Clinical, laboratory and body composition data were analysed using the Kaplan–Meier method and Cox regression model to investigate which factors are associated with prognosis.Results Of 100 patients, 31 were diagnosed with sarcopenia (L3 SMI value ≤36.2 cm 2 /m 2 for men and ≤29.6 cm 2 /m 2 for women), and 65 had IMF deposition (MA value ≤44.4 HU for men and ≤39.3 HU for women). These groups had shorter median survival than the reference groups (both P <0.0001). In multivariable analysis, sarcopenia (hazard ratio [HR], 1.921; P = 0.016), IMF deposition (HR, 3.580; P <0.001), Barcelona Clinic Liver Cancer (BCLC) stages C and D (HR: 2.396, P <0.01 and HR: 6.131, P <0.01, respectively), Japan Integrated Staging (JIS) score 4 (HR: 2.067, P = 0.020), and male gender (HR: 3.211, P <0.001) were independently associated with mortality.Conclusion Sarcopenia and IMF deposition showed superior value in combination with BCLC stage and JIS score for predicting the survival of Indonesian HCC patients. Increased awareness and strategies to prevent or reverse these factors might improve patient outcomes. (Electric word counts: 249)

Comparative study of the Japan Integrated Stage (JIS) and modified JIS score as a predictor of survival after hepatectomy for hepatocellular carcinoma

2008 ◽  
Vol 43 (5) ◽  
pp. 369-377 ◽  
Author(s):  
Kai-Zhong Luo ◽  
Toshiyuki Itamoto ◽  
Hironobu Amano ◽  
Akihiko Oshita ◽  
Yuichiro Ushitora ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Comparative Study ◽  
Jis Score

scholarly journals Sarcopenia and Low Mean Muscle Attenuation are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study

2019 ◽  
Author(s):  
Yan Mardian ◽  
Yoshihiko Yano ◽  
Neneng Ratnasari ◽  
Lina Choridah ◽  
Widya Wasityastuti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Large Scale ◽  
Cox Regression ◽  
Clinical Laboratory ◽  
Multivariable Analysis ◽  
Lumbar Vertebra ◽  
Skeletal Muscle Index ◽  
Computed Tomography Images ◽  
Muscle Attenuation ◽  
Jis Score

Abstract Background A large-scale Japanese retrospective study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Japanese patients.Methods SMI and mean muscle attenuation (MA) were evaluated using computed tomography images of the third lumbar vertebra (L3) in a prospective cohort of 100 Indonesian HCC patients. Clinical, laboratory and body composition data were analysed using the Kaplan–Meier method and Cox regression model to investigate which factors are associated with prognosis.Results Of 100 patients, 31 were diagnosed with sarcopenia (L3 SMI value ≤36.2 cm 2 /m 2 for men and ≤29.6 cm 2 /m 2 for women), and 65 had IMF deposition (MA value ≤44.4 HU for men and ≤39.3 HU for women). These groups had shorter median survival than the reference groups (both P <0.0001). In multivariable analysis, sarcopenia (hazard ratio [HR], 1.921; P = 0.016), IMF deposition (HR, 3.580; P <0.001), Barcelona Clinic Liver Cancer (BCLC) stages C and D (HR: 2.396, P <0.01 and HR: 6.131, P <0.01, respectively), Japan Integrated Staging (JIS) score 4 (HR: 2.067, P = 0.020), and male gender (HR: 3.211, P <0.001) were independently associated with mortality.Conclusion Sarcopenia and IMF deposition showed superior value in combination with BCLC stage and JIS score for predicting the survival of Indonesian HCC patients. Increased awareness and strategies to prevent or reverse these factors might improve patient outcomes. (Electric word counts: 249)

scholarly journals Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study

2019 ◽  
Author(s):  
Yan Mardian ◽  
Yoshihiko Yano ◽  
Neneng Ratnasari ◽  
Lina Choridah ◽  
Widya Wasityastuti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Large Scale ◽  
Cox Regression ◽  
Clinical Laboratory ◽  
Multivariable Analysis ◽  
Lumbar Vertebra ◽  
Intramuscular Fat ◽  
Skeletal Muscle Index ◽  
Computed Tomography Images ◽  
Jis Score

Abstract Background: A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Japanese patients. Methods: SMI and mean muscle attenuation (MA) were evaluated using computed tomography images of the third lumbar vertebra (L3) in a prospective cohort of 100 Indonesian HCC patients. Clinical, laboratory and body composition data were analysed using the Kaplan–Meier method and Cox regression model to investigate which factors are associated with prognosis. Results: Of 100 patients, 31 were diagnosed with sarcopenia (L3 SMI value ≤36.2 cm 2 /m 2 for men and ≤29.6 cm 2 /m 2 for women), and 65 had IMF deposition (MA value ≤44.4 HU for men and ≤39.3 HU for women). These groups had shorter median survival than the reference groups (both P <0.0001). In multivariable analysis, sarcopenia (hazard ratio [HR], 1.921; P = 0.016), IMF deposition (HR, 3.580; P <0.001), Barcelona Clinic Liver Cancer (BCLC) stages C and D (HR: 2.396, P <0.01 and HR: 6.131, P <0.01, respectively), Japan Integrated Staging (JIS) score 4 (HR: 2.067, P = 0.020), and male gender (HR: 3.211, P <0.001) were independently associated with mortality. Conclusion: Sarcopenia and IMF deposition showed superior value in combination with BCLC stage and JIS score for predicting the survival of Indonesian HCC patients. Increased awareness and strategies to prevent or reverse these factors might improve patient outcomes.

scholarly journals Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study

2019 ◽  
Author(s):  
Yan Mardian ◽  
Yoshihiko Yano ◽  
Neneng Ratnasari ◽  
Lina Choridah ◽  
Widya Wasityastuti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Large Scale ◽  
Cox Regression ◽  
Clinical Laboratory ◽  
Multivariable Analysis ◽  
Lumbar Vertebra ◽  
Intramuscular Fat ◽  
Skeletal Muscle Index ◽  
Computed Tomography Images ◽  
Jis Score

Abstract Background: A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Japanese patients. Methods: SMI and mean muscle attenuation (MA) were evaluated using computed tomography images of the third lumbar vertebra (L3) in a prospective cohort of 100 Indonesian HCC patients. Clinical, laboratory and body composition data were analysed using the Kaplan–Meier method and Cox regression model to investigate which factors are associated with prognosis. Results: Of 100 patients, 31 were diagnosed with sarcopenia (L3 SMI value ≤36.2 cm 2 /m 2 for men and ≤29.6 cm 2 /m 2 for women), and 65 had IMF deposition (MA value ≤44.4 HU for men and ≤39.3 HU for women). These groups had shorter median survival than the reference groups (both P <0.0001). In multivariable analysis, sarcopenia (hazard ratio [HR], 1.921; P = 0.016), IMF deposition (HR, 3.580; P <0.001), Barcelona Clinic Liver Cancer (BCLC) stages C and D (HR: 2.396, P <0.01 and HR: 6.131, P <0.01, respectively), Japan Integrated Staging (JIS) score 4 (HR: 2.067, P = 0.020), and male gender (HR: 3.211, P <0.001) were independently associated with mortality. Conclusion: Sarcopenia and IMF deposition showed superior value in combination with BCLC stage and JIS score for predicting the survival of Indonesian HCC patients. Increased awareness and strategies to prevent or reverse these factors might improve patient outcomes.

Validation of Three Staging Systems for Hepatocellular Carcinoma (JIS Score, Biomarker-Combined JIS Score and BCLC System) in 4,649 Cases from a Japanese Nationwide Survey

2014 ◽  
Vol 32 (6) ◽  
pp. 717-724 ◽  
Author(s):  
Satoshi Kitai ◽  
Masatoshi Kudo ◽  
Namiki Izumi ◽  
Shuichi Kaneko ◽  
Yonson Ku ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nationwide Survey ◽  
Staging Systems ◽  
Jis Score

scholarly journals “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yan Mardian ◽  
Yoshihiko Yano ◽  
Neneng Ratnasari ◽  
Lina Choridah ◽  
Widya Wasityastuti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Large Scale ◽  
Cox Regression ◽  
Clinical Laboratory ◽  
Multivariable Analysis ◽  
Lumbar Vertebra ◽  
Intramuscular Fat ◽  
Skeletal Muscle Index ◽  
Computed Tomography Images ◽  
Jis Score

Abstract Background A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Japanese patients. Methods SMI and mean muscle attenuation (MA) were evaluated using computed tomography images of the third lumbar vertebra (L3) in a prospective cohort of 100 Indonesian HCC patients. Clinical, laboratory and body composition data were analysed using the Kaplan–Meier method and Cox regression model to investigate which factors are associated with prognosis. Results Of 100 patients, 31 were diagnosed with sarcopenia (L3 SMI value ≤36.2 cm2/m2 for men and ≤ 29.6 cm2/m2 for women), and 65 had IMF deposition (MA value ≤44.4 HU for men and ≤ 39.3 HU for women). These groups had shorter median survival than the reference groups (both P < 0.0001). In multivariable analysis, sarcopenia (hazard ratio [HR], 1.921; P = 0.016), IMF deposition (HR, 3.580; P < 0.001), Barcelona Clinic Liver Cancer (BCLC) stages C and D (HR: 2.396, P < 0.01 and HR: 6.131, P < 0.01, respectively), Japan Integrated Staging (JIS) score 4 (HR: 2.067, P = 0.020), and male gender (HR: 3.211, P < 0.001) were independently associated with mortality. Conclusion Sarcopenia and IMF deposition showed superior value in combination with BCLC stage and JIS score for predicting the survival of Indonesian HCC patients. Increased awareness and strategies to prevent or reverse these factors might improve patient outcomes. (Electric word counts: 249).

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