Primary vascular bone tumors in the spine: a challenge for pathologists and spine oncology surgeons

AbstractPrimary malignant vascular bone tumors are unusual and include hemangioendothelioma, epitheloid hemangioendothelioma and angiosarcoma. Although few cases of primary bone angiosarcomas have been reported, those of femoral origin are even more infrequent. Such tumors diagnosis may be challenging due to their radiographic and histologic variety. We present a case of a 24-yearold woman with a subperiosteal diaphyseal angiosarcoma originating from the femoral bone and metastatic to the lung at the time of diagnosis. The clinical, histological and radiological features of this extremely rare lesion are presented.

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Correction to: Primary vascular bone tumors in the spine: a challenge for pathologists and spine oncology surgeons

European Spine Journal ◽

10.1007/s00586-019-06124-9 ◽

2019 ◽

Vol 28 (10) ◽

pp. 2433-2433

Author(s):

Stefano Boriani ◽

Riccardo Cecchinato ◽

Alberto Righi ◽

Stefano Bandiera ◽

Angelo Paolo Dei Tos ◽

...

Keyword(s):

Bone Tumors ◽

Vascular Bone Tumors

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Benign Vascular Bone Tumors

Musculoskeletal Imaging Volume 1 ◽

10.1093/med/9780190938161.003.0060 ◽

2019 ◽

pp. 303-307

Author(s):

G. Scott Stacy

Keyword(s):

Vascular Malformation ◽

Bone Tumors ◽

Treatment Strategies ◽

Epithelioid Hemangioendothelioma ◽

Vascular Tumors ◽

Slow Flow ◽

Imaging Features ◽

Epithelioid Hemangioma ◽

Vascular Bone Tumors

The classification of vascular tumors of the skeleton can be thought of as a spectrum of disease including both benign and malignant entities. Chapter 60 focuses on the benign entities, hemangioma and epithelioid hemangioma. The term hemangioma refers to a collection of blood vessels and vascular spaces, perhaps better classified as a slow-flow vascular malformation. Epithelioid hemangioma is a rare and controversial entity that may be confused with its malignant counterpart, the epithelioid hemangioendothelioma. This chapter will describe the clinical, pathophysiological, and imaging features of these benign vascular bone tumors, with a brief mention of treatment strategies. Familiarity with the imaging appearances and characteristics of these entities is essential in order to guide clinical management and to avoid unnecessary investigation into clearly benign lesions.

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Malignant Vascular Bone Tumors

Musculoskeletal Imaging Volume 1 ◽

10.1093/med/9780190938161.003.0061 ◽

2019 ◽

pp. 308-312

Author(s):

G. Scott Stacy

Keyword(s):

Bone Tumors ◽

Malignant Tumors ◽

Treatment Strategies ◽

Vascular Tumor ◽

Epithelioid Hemangioendothelioma ◽

Vascular Tumors ◽

Bone Lesions ◽

Imaging Features ◽

Vascular Bone Tumors ◽

Health Organization

The organization of vascular bone tumors can be thought of as a spectrum of disease including both benign and malignant entities. Chapter 61 focuses on the malignant tumors, which have elicited much controversy and debate. These include 2 vascular tumors of bone recognized by the World Health Organization: epithelioid hemangioendothelioma and angiosarcoma. Although there are no characteristic imaging features that would obviate the need for biopsy of these entities, they may present with multifocal bone lesions, which can suggest the diagnosis of a vascular tumor. This chapter will describe the clinical, pathophysiological, and imaging features of these malignant vascular bone tumors, with a brief mention of treatment strategies.

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Vascular bone tumors: a proposal of a classification based on clinicopathological, radiographic and genetic features

Skeletal Radiology ◽

10.1007/s00256-012-1510-6 ◽

2012 ◽

Vol 41 (12) ◽

pp. 1495-1507 ◽

Cited By ~ 32

Author(s):

Costantino Errani ◽

Daniel Vanel ◽

Marco Gambarotti ◽

Marco Alberghini ◽

Piero Picci ◽

...

Keyword(s):

Bone Tumors ◽

Genetic Features ◽

Vascular Bone Tumors

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Soft-Tissue And Bone Tumors About The Foot And Ankle

Clinics in Sports Medicine ◽

10.1016/s0278-5919(20)30292-1 ◽

1994 ◽

Vol 13 (4) ◽

pp. 909-938 ◽

Cited By ~ 5

Author(s):

Arthur K. Walling ◽

Seth I. Gasser

Keyword(s):

Soft Tissue ◽

Bone Tumors ◽

Foot And Ankle

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Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

Nuklearmedizin ◽

10.1055/s-0037-1620567 ◽

1982 ◽

Vol 21 (04) ◽

pp. 136-139 ◽

Cited By ~ 2

Author(s):

C.-J. Edeling

Keyword(s):

Soft Tissue ◽

Bone Scintigraphy ◽

Primary Tumor ◽

Bone Tumors ◽

Whole Body ◽

Skeletal Metastases ◽

Malignant Bone Tumors ◽

67Ga Scintigraphy ◽

Primary Bone Tumors ◽

Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

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MR-Derived CT-Like Images and Simulated Radiographs versus Conventional Radiography in Patients with Benign and Malignant Bone Tumors

10.1055/s-0038-1639518 ◽

2018 ◽

Author(s):

Alexandra Gersing ◽

Daniela Muenzel ◽

Felix Kopp ◽

Benedikt Schwaiger ◽

Carolin Knebel ◽

...

Keyword(s):

Bone Tumors ◽

Conventional Radiography ◽

Malignant Bone Tumors

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Computed tomography analysis of primary bone tumors : the significance in the evaluation of destructive lesionsof pelvic bone

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1988.24.4.648 ◽

1988 ◽

Vol 24 (4) ◽

pp. 648

Author(s):

J S Suh ◽

E J Lee ◽

C Y Park

Keyword(s):

Computed Tomography ◽

Bone Tumors ◽

Pelvic Bone ◽

Primary Bone Tumors ◽

Primary Bone ◽

Tomography Analysis

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CRYOSURGERY IN THE TREATMENT OF PATIENTS WITH BONE TUMORS

Problems in oncology ◽

10.37469/0507-3758-2019-65-2-165-171 ◽

2019 ◽

Vol 65 (2) ◽

pp. 165-171

Author(s):

Aleksey Belyaev ◽

Georgiy Prokhorov ◽

Anna Arkhitskaya

Keyword(s):

Liquid Nitrogen ◽

Bone Tumors ◽

Cryogenic Treatment ◽

Long Term Results ◽

Bone Lesions ◽

Giant Cell Tumors ◽

Primary Bone Tumors ◽

Circulation Circuit ◽

Recent Emergence ◽

Primary Bone

A review of the literature shows that surgical procedures will remain the standard treatment for primary bone tumors. Analysis of studies on the assessment of long-term results shows that additional double cryogenic treatment of the curettage cavity can improve the treatment outcomes of patients with giant cell tumors, dysplastic diseases and some forms of malignant lesions. The traditional execution of the procedure is associated with the open installation of liquid nitrogen in the bone cavity, which requires special skills in handling aggressive refrigerant from the staff and does not exclude complications. In case of multiple metastatic bone lesions, surgical treatment is not indicated. The recent emergence in clinical practice of new equipment with a closed liquid nitrogen circulation circuit inside cryoprobes resumes interest in cryoabla-tion of bone tumor lesions using modern minimally invasive puncture cryotechnology and expanding indications for its use in patients with severe comorbidities.

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