Dynamics of device-based treatments for Parkinson’s disease in Germany from 2010 to 2017: application of continuous subcutaneous apomorphine, levodopa–carbidopa intestinal gel, and deep brain stimulation

2019 ◽  
Vol 126 (7) ◽  
pp. 879-888 ◽  
Author(s):  
Daniel Richter ◽  
Dirk Bartig ◽  
Wolfgang Jost ◽  
Christoph Jörges ◽  
Britta Stumpe ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Subcutaneous Apomorphine ◽  
Deep Brain

Continuous subcutaneous apomorphine in advanced Parkinson’s disease patients treated with deep brain stimulation

2019 ◽  
Vol 266 (3) ◽  
pp. 659-666 ◽  
Author(s):  
Ángel Sesar ◽  
Gustavo Fernández-Pajarín ◽  
Begoña Ares ◽  
José-Luis Relova ◽  
Eduardo Arán ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Advanced Parkinson’S Disease ◽  
Subcutaneous Apomorphine ◽  
Deep Brain

scholarly journals Continuous subcutaneous apomorphine infusion allowing awake deep brain stimulation in a Parkinson’s disease patient

2021 ◽  
Vol 7 (S1) ◽  
Author(s):  
Francesca Spagnolo ◽  
Francesco Romeo ◽  
Piermassimo Proto ◽  
Augusto Maria Rini ◽  
Emanuela Leopizzi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Perioperative Complications ◽  
Disease Patient ◽  
Continuous Administration ◽  
Subcutaneous Apomorphine ◽  
The Right ◽  
Deep Brain

Abstract Background Subthalamic Deep Brain Stimulation (DBS) have demonstrated in the last decades to determine an important clinical improvement in advanced and selected Parkinson’s disease (PD) patients. However, only a minority of parkinsonian patients meet the criteria to undergo DBS, and the surgical procedure itself is often stressful, especially for patients experiencing severe OFF state. Subcutaneous Apomorphine continuous administration is suitable as an adjunctive therapy capable of improving a suboptimal DBS result. Here we hypothesize a possible role for subcutaneous apomorphine infusion to alleviate severe OFF state in parkinsonian patients undergoing DBS, thus allowing intraoperative microrecording and patient’s collaboration during clinical testing. Case presentation A 68-year-old man, suffering from a very long PD-history, characterized by a severe akinetic status and dramatic non-motor features while in OFF, underwent Subthalamic-DBS keeping a slight but continuous apomorphine infusion (1.8 mg/hour), able to guarantee the right degree of patient’s collaboration without interfering with microelectrode recordings. There were no intra or perioperative complications and after the procedure he experienced a marked clinical benefit, being able to stop apomorphine administration. Conclusions Here we described the first Subthalamic DBS procedure performed with a low and stable dopaminergic stimulation guaranteed by subcutaneous Apomorphine continuous infusion. For its rapidity of action and prompt reversibility, apomorphine could be particularly suitable for use during difficult surgical procedures in PD, allowing more therapeutic opportunities for patients who would otherwise be excluded from the DBS option.

Influence of deep brain stimulation and levodopa on signs and symptoms in Parkinson's disease

2009 ◽  
Vol 36 (S 02) ◽  
Author(s):  
J Gierthmühlen ◽  
P Arning ◽  
G Wasner ◽  
A Binder ◽  
J Herzog ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Signs And Symptoms ◽  
Deep Brain

The effects of subthalamic nucleus deep brain stimulation on precision grip abnormalities in Parkinson's disease

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
S Fellows ◽  
M Kronenbürger ◽  
N Allert ◽  
C Fromm ◽  
J Noth ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Precision Grip ◽  
Deep Brain
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