Characterization of Epstein-Barr virus type 1 nuclear antigen 3C sequence patterns of nasopharyngeal and gastric carcinomas in northern China

2012 ◽  
Vol 157 (5) ◽  
pp. 845-853 ◽  
Author(s):  
Guocai Wu ◽  
Yun Wang ◽  
Yan Chao ◽  
Yuping Jia ◽  
Chengquan Zhao ◽  
...  
Keyword(s):  
Virus Type ◽  
Epstein Barr Virus ◽  
Northern China ◽  
Nuclear Antigen ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Sequence Patterns ◽  
Epstein Barr

Variations of Epstein-Barr virus nuclear antigen 1 gene in gastric carcinomas and nasopharyngeal carcinomas from Northern China

2010 ◽  
Vol 147 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Yun Wang ◽  
Xia Liu ◽  
Xiaoming Xing ◽  
Ying Cui ◽  
Chengquan Zhao ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Northern China ◽  
Nuclear Antigen ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Epstein Barr

Characterization of Epstein-Barr virus-encoded small RNA gene variations in virus associated lymphomas in Northern China

2017 ◽  
Vol 162 (6) ◽  
pp. 1609-1616 ◽  
Author(s):  
Zhenzhen Zhao ◽  
Lingling Sun ◽  
Song Liu ◽  
Jun Shu ◽  
Bing Luo
Keyword(s):  
Small Rna ◽  
Epstein Barr Virus ◽  
Northern China ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Characterization of an human leucocyte antigen A2-restricted Epstein-Barr virus nuclear antigen-1-derived cytotoxic T-lymphocyte epitope

Immunology ◽  
2010 ◽  
Vol 129 (3) ◽  
pp. 386-395 ◽  
Author(s):  
Diego Marescotti ◽  
Federica Destro ◽  
Anna Baldisserotto ◽  
Mauro Marastoni ◽  
Giuseppe Coppotelli ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Epstein Barr Virus ◽  
Human Leucocyte Antigen ◽  
Cytotoxic T Lymphocyte ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Latent Gene Sequencing Reveals Familial Relationships among Chinese Epstein-Barr Virus Strains and Evidence for Positive Selection of A11 Epitope Changes

2003 ◽  
Vol 77 (21) ◽  
pp. 11517-11530 ◽  
Author(s):  
R. S. Midgley ◽  
A. I. Bell ◽  
D. J. McGeoch ◽  
A. B. Rickinson
Keyword(s):  
Epstein Barr Virus ◽  
Sequence Divergence ◽  
Nuclear Antigen ◽  
Coding Region ◽  
Immune Selection ◽  
Genomic Context ◽  
Barr Virus ◽  
Epstein Barr

ABSTRACT Epstein-Barr virus (EBV) strains from the highly HLA-A11-positive Chinese population are predominantly type 1 and show a variety of sequence changes (relative to the contemporary Caucasian prototype strain B95.8) in the nuclear antigen EBNA3B sequences encoding two immunodominant HLA-A11 epitopes, here called IVT and AVF. This has been interpreted by some as evidence of immune selection and by others as random genetic drift. To study epitope variation in a broader genomic context, we sequenced the whole of EBNA3B and parts of the EBNA2, 3A, and 3C genes from each of 31 Chinese EBV isolates. At each locus, type 1 viruses showed <2% nucleotide divergence from the B95.8 prototype while type 2 sequences remained even closer to the contemporary African prototype Ag876. However, type 1 isolates could clearly be divided into families based on linked patterns of sequence divergence from B95.8 across all four EBNA loci. Different patterns of IVT and AVF variation were associated with the different type 1 families, and there was additional epitope diversity within families. When the EBNA3 gene sequences of type 1 Chinese strains were subject to computer-based analysis, particular codons within the A11-epitope-coding region were among the few identified as being under positive or diversifying selection pressure. From these results, and the observation that mutant epitopes are consistently nonimmunogenic in vivo, we conclude that the immune selection hypothesis remains viable and worthy of further investigation.

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